Journal
INORGANICA CHIMICA ACTA
Volume 362, Issue 1, Pages 125-135Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2008.03.092
Keywords
Rheumatoid arthritis; Copper(II); Speciation; Potentiometry; Spectroscopy; Bio-modelling; Bio-distribution
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Funding
- National Research Foundation (NRF)
- Canon Collins Trust
- Council of the University of Cape Town
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Copper complexes of N,N'-di(aminoethylene)-2,6-pyridinedicarbonylamine and bis-(N,N-dimethylethyl)-2,6- pyridinedicarboxamide have been studied by glass electrode potentiometry, NMR, UV and IR spectroscopy as potential anti-inflammatory agents for the alleviation of inflammation associated with rheumatoid arthritis. The protonation and formation constants with Cu(II), Zn(II) and Ca(II), determined at 25 degrees C and an ionic strength of 0.15 mol dm (3) were used to calculate the copper plasma mobilizing index of the ligands. Spectroscopic studies suggested that metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal distorted copper complexes. Bio-distribution and dermal absorption studies showed the complexes to have relatively long biological half-lives with 50% of the injected dose remaining in the body 24 h after administration. (c) 2008 Elsevier B.V. All rights reserved.
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