Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 44, Issue 5, Pages 1878-1883Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2008.11.001
Keywords
Polymer-metal complex; DNA binding; Antibacterial activity; Antifungal activity
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Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi [01(2075)/06/EMR-II]
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Some water-soluble polymer-copper(II) complexes, [Cu(phen)(L-phe)(BPEI)]ClO4 center dot 4H(2)O (phen=1,10-phenanthroline, L-phe = L-phenylalanine, and BPEI = branched polyethyleneimine), with various amounts of copper(II) chelates in the polymer chain, were prepared by ligand substitution method in water-ethanol medium and characterized by infra-red, UV-visible, EPR spectral and elemental analysis methods. Binding of these complexes with calf thymus DNA (CT DNA) has been investigated by absorption spectroscopy, emission spectroscopy and gel electrophoresis techniques. The experimental results indicate that the amount of copper(II) chelate content in the polymer backbone have marked effect on the binding affinity to CT DNA. Interactions like electrostatic interaction, van der Waals interaction, hydrogen bonding and/or partial intercalation binding modes exist in this system. A sample of polymer-copper(II) complex was tested for its antibacterial and antifungal activity against certain human pathogenic organisms and it was found to have good antibacterial and antifungal activities. (C) 2008 Elsevier Masson SAS. All rights reserved.
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