Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 18, Pages 5422-5425Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.07.114
Keywords
RGD conjugate; Cyclam; DOTA; Cu-64 PET
Categories
Funding
- Universite Joseph Fourier
- Centre National de la Recherche Scientifique (CNRS)
- NanoBio (Grenoble)
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Cyclam and DOTA-containing positron emission tomography radiotracers were prepared by using a modular chemical strategy based on peptide synthesis and chemoselective ligations. These molecules encompass two functional domains, one a tumour 'homing' domain and the other a chelating ligand for copper allowing nuclear imaging of tumours. (c) 2010 Elsevier Ltd. All rights reserved.
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