Wnt/β-catenin signalling: from plasma membrane to nucleus

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

(2012) J. Waaler et al.   CANCER RESEARCH

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning

(2012) Wan-tae Kim et al.   EMBO JOURNAL

Polyvalent DP1 keeps the Wnt pathway neat and tidy

(2012) François Fagotto   EMBO JOURNAL

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

Delicate Analysis of Post-Translational Modifications on Dishevelled 3

(2012) Chaochao Wu et al.   JOURNAL OF PROTEOME RESEARCH

Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell Proliferation

(2012) R. Hrdlickova et al.   MOLECULAR AND CELLULAR BIOLOGY

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

ADP-ribosylation factors 1 and 6 regulate Wnt/β-catenin signaling via control of LRP6 phosphorylation

(2012) W Kim et al.   ONCOGENE

Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity

(2012) Z.-Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Regulates TERT--Putting the Horse Before the Cart

(2012) C. W. Greider   SCIENCE

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

(2011) Nu Zhang et al.   CANCER CELL

Location, Location, Location: FoxM1 Mediates β-Catenin Nuclear Translocation and Promotes Glioma Tumorigenesis

(2011) Angela Bowman et al.   CANCER CELL

Phospholipase D Meets Wnt Signaling: A New Target for Cancer Therapy: Figure 1.

(2011) Dong Woo Kang et al.   CANCER RESEARCH

β-Catenin Enhances Oct-4 Activity and Reinforces Pluripotency through a TCF-Independent Mechanism

(2011) Kevin F. Kelly et al.   Cell Stem Cell

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2to LRP6 phosphorylation

(2011) Kristina Tanneberger et al.   EMBO JOURNAL

Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia

(2011) J. B. Wallingford et al.   GENES & DEVELOPMENT

Phosphorylation of TCF Proteins by Homeodomain-interacting Protein Kinase 2

(2011) Hiroki Hikasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zipper-interacting Protein Kinase (ZIPK) Modulates Canonical Wnt/β-Catenin Signaling through Interaction with Nemo-like Kinase and T-cell Factor 4 (NLK/TCF4)

(2011) Sumihito Togi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling

(2011) Buzz Baum et al.   JOURNAL OF CELL BIOLOGY

The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/ -Catenin Signaling

(2011) T. T. H. Lui et al.   MOLECULAR AND CELLULAR BIOLOGY

Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation

(2011) J. Liang et al.   MOLECULAR AND CELLULAR BIOLOGY

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling

(2011) B Cha et al.   ONCOGENE

E2F1 suppresses Wnt/β-catenin activity through transactivation of β-catenin interacting protein ICAT

(2011) Z Wu et al.   ONCOGENE

Phospholipase D1 Drives a Positive Feedback Loop to Reinforce the Wnt/ -Catenin/TCF Signaling Axis

(2010) D. W. Kang et al.   CANCER RESEARCH

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

Regulation of Lrp6 phosphorylation

(2010) Christof Niehrs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histone Deacetylase 7 Controls Endothelial Cell Growth Through Modulation of β-Catenin

(2010) Andriana Margariti et al.   CIRCULATION RESEARCH

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification

(2010) Hiroki Hikasa et al.   DEVELOPMENTAL CELL

Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling

(2010) Monther Abu-Remaileh et al.   EMBO JOURNAL

Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1

(2010) Koji Kikuchi et al.   EMBO JOURNAL

Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/ -catenin signal via ISGylation of  -catenin

(2010) J. H. Lee et al.   GUT

Myristoylated Naked2 Antagonizes Wnt-β-Catenin Activity by Degrading Dishevelled-1 at the Plasma Membrane

(2010) Tianhui Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protein Stability of Axin, a Negative Regulator of Wnt Signaling, Is Regulated by Smad Ubiquitination Regulatory Factor 2 (Smurf2)

(2010) Sewoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p15RS Attenuates Wnt/β-Catenin Signaling by Disrupting β-Catenin·TCF4 Interaction

(2010) Yinyuan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of  -catenin mRNA

(2010) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

The EDD E3 ubiquitin ligase ubiquitinates and up-regulates β-catenin

(2010) Avital Hay-Koren et al.   MOLECULAR BIOLOGY OF THE CELL

RORα Attenuates Wnt/β-Catenin Signaling by PKCα-Dependent Phosphorylation in Colon Cancer

(2010) Ji Min Lee et al.   MOLECULAR CELL

S-Nitrosylation of β-Catenin by eNOS-Derived NO Promotes VEGF-Induced Endothelial Cell Permeability

(2010) Sébastien Thibeault et al.   MOLECULAR CELL

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

Positive Feedback Regulation between Phospholipase D and Wnt Signaling Promotes Wnt-Driven Anchorage-Independent Growth of Colorectal Cancer Cells

(2010) Dong Woo Kang et al.   PLoS One

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

(2010) K. R. Holloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

G   Activates GSK3 to Promote LRP6-Mediated  -Catenin Transcriptional Activity

(2010) K. K. Jernigan et al.   Science Signaling

Trafficking, Acidification, and Growth Factor Signaling

(2010) C. Niehrs et al.   Science Signaling

Wnt Trafficking: New Insights into Wnt Maturation, Secretion and Spreading

(2010) Fillip Port et al.   TRAFFIC

Emerging links between CDK cell cycle regulators and Wnt signaling

(2010) Gary Davidson et al.   TRENDS IN CELL BIOLOGY

Proteasome Nuclear Activity Affects Chromosome Stability by Controlling the Turnover of Mms22, a Protein Important for DNA Repair

(2010) Shay Ben-Aroya et al.   PLoS Genetics

Oncogenic Function of ATDC in Pancreatic Cancer through Wnt Pathway Activation and β-Catenin Stabilization

(2009) Lidong Wang et al.   CANCER CELL

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways

(2009) A. Ruzov et al.   DEVELOPMENT

Cell Cycle Control of Wnt Receptor Activation

(2009) Gary Davidson et al.   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Negative feedback regulation of Wnt signaling by Gβγ-mediated reduction of Dishevelled

(2009) Hwajin Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway

(2009) Minyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of Chibby affects function of motile airway cilia

(2009) Vera A. Voronina et al.   JOURNAL OF CELL BIOLOGY

Dishevelled-2 docks and activates Src in a Wnt-dependent manner

(2009) Noriko Yokoyama et al.   JOURNAL OF CELL SCIENCE

Nuclear-Cytoplasmic Shuttling of Menin Regulates Nuclear Translocation of  -Catenin

(2009) Y. Cao et al.   MOLECULAR AND CELLULAR BIOLOGY

EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin

(2009) Haitao Ji et al.   MOLECULAR CELL

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization

(2009) Matias Simons et al.   NATURE CELL BIOLOGY

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Impaired Wnt–β-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy

(2009) Madeline A Lancaster et al.   NATURE MEDICINE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

An olive branch to two theories

(2009) Leonie Welberg   NATURE REVIEWS NEUROSCIENCE

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6

(2009) Lorna S. Kategaya et al.   PLoS One

Regulation of ciliary polarity by the APC/C

(2009) A. Ganner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

(2008) Min Jung Kim et al.   FASEB JOURNAL

Sox9 Inhibits Wnt Signaling by Promoting β-Catenin Phosphorylation in the Nucleus

(2008) Lilia Topol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chibby cooperates with 14-3-3 to regulate β-catenin subcellular distribution and signaling activity

(2008) Feng-Qian Li et al.   JOURNAL OF CELL BIOLOGY

Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation

(2008) Yu Ding et al.   JOURNAL OF CELL BIOLOGY

Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction

(2008) Xiao-qing Gan et al.   JOURNAL OF CELL BIOLOGY

E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

(2008) Erick J. Morris et al.   NATURE

Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL

(2008) Vipul C. Chitalia et al.   NATURE CELL BIOLOGY

A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription

(2008) J. Mieszczanek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation

(2008) W. Pan et al.   SCIENCE

New Regulators of Wnt/ -Catenin Signaling Revealed by Integrative Molecular Screening

(2008) M. B. Major et al.   Science Signaling