Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity

Parkin-induced ubiquitination of Mff promotes its association with p62/SQSTM1 during mitochondrial depolarization

(2015) Ju Gao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Molecular mechanisms underlying PINK1 and Parkin catalyzed ubiquitylation of substrates on damaged mitochondria

(2015) Fumika Koyano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Erratum: AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2015) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

How phosphoubiquitin activates Parkin

(2015) Xinde Zheng et al.   CELL RESEARCH

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

(2015) A. Kumar et al.   EMBO JOURNAL

A Ubl/ubiquitin switch in the activation of Parkin

(2015) V. Sauve et al.   EMBO JOURNAL

The E3 Ubiquitin Ligase Parkin Is Recruited to the 26 S Proteasome via the Proteasomal Ubiquitin Receptor Rpn13

(2015) Miguel A. Aguileta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

PINK1 Triggers Autocatalytic Activation of Parkin to Specify Cell Fate Decisions

(2014) Conggang Zhang et al.   CURRENT BIOLOGY

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

(2014) T. Wauer et al.   EMBO JOURNAL

Lysine 63-linked Polyubiquitination Is Dispensable for Parkin-mediated Mitophagy

(2014) Kahori Shiba-Fukushima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase

(2014) Nicol Birsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently

(2014) F. C. Fiesel et al.   JOURNAL OF CELL SCIENCE

The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy

(2014) Sven Geisler et al.   JOURNAL OF CELL SCIENCE

New insights into ubiquitin E3 ligase mechanism

(2014) Christopher E Berndsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

(2014) Marcello Clerici et al.   Nature Communications

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

(2014) A. Kazlauskaite et al.   Open Biology

Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

(2014) Thomas R. Caulfield et al.   PLoS Computational Biology

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

(2014) Kahori Shiba-Fukushima et al.   PLoS Genetics

Structure of the human Parkin ligase domain in an autoinhibited state

(2013) Tobias Wauer et al.   EMBO JOURNAL

Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells andDrosophila

(2013) Saera Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

(2013) Kei Okatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

(2013) Michael Lazarou et al.   JOURNAL OF CELL BIOLOGY

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

S-nitrosylation regulates mitochondrial quality control via activation of parkin

(2013) Kentaro Ozawa et al.   Scientific Reports

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

(2013) Jean-François Trempe et al.   Frontiers in Neurology

The role of UBL domains in ubiquitin-specific proteases

(2012) Alex C. Faesen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution structure of the E3 ligase HOIL-1 Ubl domain

(2012) Steven A. Beasley et al.   PROTEIN SCIENCE

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis

(2011) Matthew E. Gegg et al.   Autophagy

Structure of the USP15 N-Terminal Domains: A β-Hairpin Mediates Close Association between the DUSP and UBL Domains

(2011) Stephen Harper et al.   BIOCHEMISTRY

Autoregulation of Parkin activity through its ubiquitin-like domain

(2011) Viduth K Chaugule et al.   EMBO JOURNAL

Structural variability of the ubiquitin specific protease DUSP-UBL double domains

(2011) Paul R. Elliott et al.   FEBS LETTERS

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Parkin Ubiquitinates Drp1 for Proteasome-dependent Degradation

(2011) Hongxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

(2011) Liliane Glauser et al.   JOURNAL OF NEUROCHEMISTRY

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1

(2011) Chengqun Huang et al.   PLoS One

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

(2010) Sumihiro Kawajiri et al.   FEBS LETTERS

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

(2010) Kei Okatsu et al.   GENES TO CELLS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

Pathogenesis of familial Parkinson’s disease: new insights based on monogenic forms of Parkinson’s disease

(2009) Taku Hatano et al.   JOURNAL OF NEUROCHEMISTRY

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin

(2008) Koji Tomoo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS