Lysine 63-linked Polyubiquitination Is Dispensable for Parkin-mediated Mitophagy

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently

(2014) F. C. Fiesel et al.   JOURNAL OF CELL SCIENCE

The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy

(2014) Sven Geisler et al.   JOURNAL OF CELL SCIENCE

PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila

(2014) Kahori Shiba-Fukushima et al.   PLoS Genetics

Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism

(2013) Xinde Zheng et al.   CELL RESEARCH

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

(2013) Kei Okatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

(2013) Naonobu Fujita et al.   JOURNAL OF CELL BIOLOGY

SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria

(2013) Hitoshi Murata et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in the Intellectual Disability Gene Ube2a Cause Neuronal Dysfunction and Impair Parkin-Dependent Mitophagy

(2013) Dominik M. Haddad et al.   MOLECULAR CELL

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

Proteasome Inhibition Promotes Parkin-Ubc13 Interaction and Lysine 63-Linked Ubiquitination

(2013) Grace G. Y. Lim et al.   PLoS One

Fluorescence-Based Sensors to Monitor Localization and Functions of Linear and K63-Linked Ubiquitin Chains in Cells

(2012) Sjoerd J.L. van Wijk et al.   MOLECULAR CELL

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

NOPO modulates Egr-induced JNK-independent cell death in Drosophila

(2011) Xianjue Ma et al.   CELL RESEARCH

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

(2010) Sumihiro Kawajiri et al.   FEBS LETTERS

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Parkin stabilizes PINK1 through direct interaction

(2009) Kahori Shiba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY