Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

Clearance of Mutant Proteins as a Therapeutic Target in Neurodegenerative Diseases

(2010) Dimitri Krainc   ARCHIVES OF NEUROLOGY

High-throughput screening and small animal models, where are we?

(2010) Jean Giacomotto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Strategies for the Inhibition of Protein Aggregation in Human Diseases

(2010) Manuela Bartolini et al.   CHEMBIOCHEM

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

(2010) J. Rihel et al.   SCIENCE

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

(2009) Terence I. Moy et al.   ACS Chemical Biology

Cdc25B Dual-Specificity Phosphatase Inhibitors Identified in a High-Throughput Screen of the NIH Compound Library

(2009) Paul A. Johnston et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters

(2009) Paul Gleeson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel trends in high-throughput screening

(2009) Lorenz M Mayr et al.   CURRENT OPINION IN PHARMACOLOGY

HTS and hit finding in academia – from chemical genomics to drug discovery

(2009) Julie A. Frearson et al.   DRUG DISCOVERY TODAY

Molecular Mechanisms of Rhodopsin Retinitis Pigmentosa and the Efficacy of Pharmacological Rescue

(2009) Mark P. Krebs et al.   JOURNAL OF MOLECULAR BIOLOGY

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

(2009) Gabriela Molina et al.   Nature Chemical Biology

Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay

(2009) Ikechukwu Okoli et al.   PLoS One

Development of a 384-Well Colorimetric Assay to Quantify Hydrogen Peroxide Generated by the Redox Cycling of Compounds in the Presence of Reducing Agents

(2008) Paul A. Johnston et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Caenorhabditis elegans as a model for lysosomal storage disorders

(2008) Gert de Voer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular and cellular aspects of protein misfolding and disease

(2008) Eszter Herczenik et al.   FASEB JOURNAL

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

Modeling Molecular and Cellular Aspects of Human Disease Using the Nematode Caenorhabditis elegans

(2008) Gary A Silverman et al.   PEDIATRIC RESEARCH

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE