Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
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Title
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
Authors
Keywords
Hepatocyte in vitro system, Alternative methods, In vitro/in vivo comparison, Genotoxic and non-genotoxic carcinogens, In vitro pharmacokinetics
Journal
ARCHIVES OF TOXICOLOGY
Volume 87, Issue 2, Pages 337-345
Publisher
Springer Nature
Online
2012-12-28
DOI
10.1007/s00204-012-0999-8
References
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