Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

The dawning of a new age of toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Food for thought … on the evolution of toxicology and the phasing out of animal testing

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Food for thought ... considerations and guidelines for basic test method descriptions in toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

(2014) David Basketter   ALTEX-Alternatives to Animal Experimentation

A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin   C as a Compatible Prognostic Marker in Human Solid Tumors

(2012) M. Schmidt et al.   CLINICAL CANCER RESEARCH

Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells

(2012) Bastian Zimmer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Compound selection for in vitro modeling of developmental neurotoxicity

(2012) Suzanne Kadereit   Frontiers in Bioscience-Landmark

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome

(2012) Nina V. Balmer et al.   HUMAN MOLECULAR GENETICS

Extensive Transcriptional Regulation of Chromatin Modifiers during Human Neurodevelopment

(2012) Matthias K. Weng et al.   PLoS One

Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells

(2012) Kesavan Meganathan et al.   PLoS One

Gene Expression Signatures Defining Fundamental Biological Processes in Pluripotent, Early, and Late Differentiated Embryonic Stem Cells

(2012) John Antonydas Gaspar et al.   STEM CELLS AND DEVELOPMENT

Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn)

(2012) P.T. Theunissen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Validation and quality control of replacement alternatives – current status and future challenges

(2012) Marcel Leist et al.   Toxicology Research

Use of Antiepileptic Medications in Pregnancy in Relation to Risks of Birth Defects

(2011) Martha M. Werler et al.   ANNALS OF EPIDEMIOLOGY

Developmental toxicity testing in the 21st century: the sword of Damocles shattered by embryonic stem cell assays?

(2011) Andrea Seiler et al.   ARCHIVES OF TOXICOLOGY

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells

(2011) Philipp B. Kuegler et al.   GLIA

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line

(2011) Diana Scholz et al.   JOURNAL OF NEUROCHEMISTRY

Methylmercury and Brain Development: Imprecision and Underestimation of Developmental Neurotoxicity in Humans

(2011) Philippe Grandjean et al.   MOUNT SINAI JOURNAL OF MEDICINE

Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes

(2011) Caiying Wang et al.   NEUROSCIENCE LETTERS

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

(2011) Christoph van Thriel et al.   NEUROTOXICOLOGY

Comparison of MeHg-induced toxicogenomic responses across in vivo and in vitro models used in developmental toxicology

(2011) Joshua F. Robinson et al.   REPRODUCTIVE TOXICOLOGY

Transcriptomic Concentration-Response Evaluation of Valproic Acid, Cyproconazole, and Hexaconazole in the Neural Embryonic Stem Cell Test (ESTn)

(2011) Peter T. Theunissen et al.   TOXICOLOGICAL SCIENCES

Sensitivity of Dopaminergic Neuron Differentiation from Stem Cells to Chronic Low-Dose Methylmercury Exposure

(2011) Bastian Zimmer et al.   TOXICOLOGICAL SCIENCES

Assessment of Chemical-Induced Impairment of Human Neurite Outgrowth by Multiparametric Live Cell Imaging in High-Density Cultures

(2011) Nina V. Stiegler et al.   TOXICOLOGICAL SCIENCES

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation

(2010) S Jagtap et al.   BRITISH JOURNAL OF PHARMACOLOGY

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

(2010) B Zimmer et al.   CELL DEATH AND DIFFERENTIATION

Expander: from expression microarrays to networks and functions

(2010) Igor Ulitsky et al.   Nature Protocols

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man

(2010) Jochem Louisse et al.   TOXICOLOGICAL SCIENCES

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Valproic Acid–Induced Deregulation In Vitro of Genes Associated In Vivo with Neural Tube Defects

(2009) Måns Jergil et al.   TOXICOLOGICAL SCIENCES

The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer

(2008) M. Schmidt et al.   CANCER RESEARCH

A Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426

(2008) Susan L. Makris et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neurodevelopmental toxicity of methylmercury: Laboratory animal data and their contribution to human risk assessment

(2008) Anna F. Castoldi et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells

(2008) Tina C. Stummann et al.   TOXICOLOGY