Simple Biological Systems for Assessing the Activity of Superoxide Dismutase Mimics

Metalloporphyrins as Therapeutic Catalytic Oxidoreductants in Central Nervous System Disorders

(2013) Huaxin Sheng et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of Metalloporphyrins on Reducing Inflammation and Autoimmunity

(2013) Meghan M. Delmastro-Greenwood et al.   ANTIOXIDANTS & REDOX SIGNALING

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

(2013) Ines Batinic-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone

(2013) Danxia Liu et al.   BMC NEUROSCIENCE

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial

(2013) J. L. Welsh et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+

(2013) Tin Weitner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitrone-based therapeutics for neurodegenerative diseases: Their use alone or in combination with lanthionines

(2013) Robert A. Floyd et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential Coordination Demands in Fe versus Mn Water-Soluble Cationic Metalloporphyrins Translate into Remarkably Different Aqueous Redox Chemistry and Biology

(2013) Artak Tovmasyan et al.   INORGANIC CHEMISTRY

The Potential of Zn(II) N-Alkylpyridylporphyrins for Anticancer Therapy

(2012) Ludmil Benov et al.   Anti-Cancer Agents in Medicinal Chemistry

A Combination of Two Antioxidants (An SOD Mimic and Ascorbate) Produces a Pro-Oxidative Effect Forcing Escherichia coli to Adapt Via Induction of oxyR Regulon

(2012) Ines Batinic-Haberle et al.   Anti-Cancer Agents in Medicinal Chemistry

Anti-Cancer Activity of Nitrones and Observations on Mechanism of Action

(2012) Robert A. Floyd et al.   Anti-Cancer Agents in Medicinal Chemistry

Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues

(2012) Rosalind A. Rosenthal et al.   Anti-Cancer Agents in Medicinal Chemistry

Regulators of oxidative stress response genes in Escherichia coli and their functional conservation in bacteria

(2012) Sarah M. Chiang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages

(2012) Anne-Sophie Bernard et al.   DALTON TRANSACTIONS

Potential of Manganoporphyrins to Enhance the Efficacy of Pharmacological Ascorbate in the Treatment of Pancreatic Cancer

(2012) Malvika Rawal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Understanding Differences in Mechanisms of Action of Fe vs Mn Porphyrins: Comparison of Their Reactivities Towards Cellular Reductants and Reactive Species

(2012) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity

(2012) Zrinka Rajic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mononuclear Iron Enzymes Are Primary Targets of Hydrogen Peroxide Stress

(2012) Adil Anjem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic peroxynitrite decomposition improves reperfusion injury after heart transplantation

(2012) Gábor Szabó et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Oxygen: How Do We Stand It?

(2012) Irwin Fridovich   MEDICAL PRINCIPLES AND PRACTICE

Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-Based Redox Modulators

(2012) Artak Tovmasyan et al.   MEDICAL PRINCIPLES AND PRACTICE

Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer

(2012) Daniel A. Monti et al.   PLoS One

Biologically relevant mechanism for catalytic superoxide removal by simple manganese compounds

(2012) K. Barnese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manganese superoxide dismutase, MnSOD and its mimics

(2011) Sumitra Miriyala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The peroxynitrite catalyst WW-85 improves microcirculation in ovine smoke inhalation injury and septic shock

(2011) Dirk M. Maybauer et al.   BURNS

Microbial Growth Curves: What the Models Tell Us and What They Cannot

(2011) Micha Peleg et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Amyotrophic Lateral Sclerosis: From Research to Therapeutic Attempts and Therapeutic Perspectives

(2011) A. Contestabile   CURRENT MEDICINAL CHEMISTRY

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(iii) N-methoxyalkylpyridylporphyrins

(2011) Artak G. Tovmasyan et al.   DALTON TRANSACTIONS

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics

(2011) Ines Batinic-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Translational research involving oxidative stress and diseases of aging

(2011) Robert A. Floyd et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytotoxic effects of Mn(III)N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate

(2011) Xiaodong Ye et al.   FREE RADICAL RESEARCH

Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury

(2010) Matthias Lange et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Protein damage by photo-activated Zn(II) N-alkylpyridylporphyrins

(2010) Ludmil Benov et al.   AMINO ACIDS

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

(2010) Ines Batinic-Haberle et al.   AMINO ACIDS

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

(2010) Ines Batinić-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Metalloporphyrin Synergizes with Ascorbic Acid to Inhibit Cancer Cell Growth Through Fenton Chemistry

(2010) Junqiang Tian et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

(2010) J. Du et al.   CLINICAL CANCER RESEARCH

Superoxide dismutase: an industrial perspective

(2010) Amit Bafana et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Cationic Mn Porphyrins Change Their Action from anti- to pro-oxidative in the Presence of Cellular Reductants: Relevance to understanding the beneficial therapeutic effects of SOD mimics in vivo

(2010) Zrinka Rajic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Accumulation of Porphyrin-based SOD Mimics in Mitochondria is Proportional to Their Lipophilicity: S. cerevisiae Study of ortho Mn(III) N-alkylpyridylporphyrins

(2010) Ivan Spasojevic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site

(2010) Ivan Spasojevic et al.   FREE RADICAL RESEARCH

The basic and applied aspects of superoxide dismutase

(2010) Amit Bafana et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

The Peroxynitrite Catalyst WW-85 Improves Pulmonary Function in Ovine Septic Shock

(2010) Dirk M. Maybauer et al.   SHOCK

Lipophilicity of potent porphyrin-based antioxidants: Comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins

(2009) Ivan Kos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury

(2009) Tiziana Genovese et al.   FREE RADICAL RESEARCH

Orally available Mn porphyrins with superoxide dismutase and catalase activities

(2009) Rosalind A. Rosenthal et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

High Lipophilicity of meta Mn(III)N-Alkylpyridylporphyrin-Based Superoxide Dismutase Mimics Compensates for Their Lower Antioxidant Potency and Makes Them as Effective as Ortho Analogues in Protecting Superoxide Dismutase-DeficientEscherichia coli

(2009) Ivan Kos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics

(2009) Júlio S. Rebouças et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Phase I clinical trial of i.v. ascorbic acid in advanced malignancy

(2008) L. J. Hoffer et al.   ANNALS OF ONCOLOGY

Cellular Defenses against Superoxide and Hydrogen Peroxide

(2008) James A. Imlay   Annual Review of Biochemistry

SOD-like activity of Mn(II) β-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself

(2008) Gilson DeFreitas-Silva et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: The effect of charge distribution

(2008) Júlio S. Rebouças et al.   DALTON TRANSACTIONS

Prooxidant activity of the superoxide dismutase (SOD)-mimetic EUK-8 in proliferating and growth-arrested Escherichia coli cells

(2008) Filip Matthijssens et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: Protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier

(2008) Júlio S. Rebouças et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pure MnTBAP selectively scavenges peroxynitrite over superoxide: Comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes

(2008) Júlio S. Rebouças et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NXY-059 for the Treatment of Acute Stroke

(2008) Hans-Christoph Diener et al.   STROKE