Journal
DALTON TRANSACTIONS
Volume 41, Issue 21, Pages 6399-6403Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt12479c
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Funding
- ENS
- CNRS [UMR8640, 7203]
- Universite Pierre et Marie Curie Paris [6]
- ANR
- ANR, HYVC
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SOD-mimics are small complexes that reproduce the activity of superoxide dismutases, natural proteins that catalytically dismutate the superoxide anion. Activated macrophages, which produce ROS and RNS fluxes, constitute a relevant model to challenge antioxidant activity in a cellular context and were used to test a Mn-complex which was shown to efficiently alter the flow of O-2(-), ONOO- and H2O2.
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