Therapeutic strategies in Parkinson's disease: what we have learned from animal models
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Therapeutic strategies in Parkinson's disease: what we have learned from animal models
Authors
Keywords
-
Journal
Annals of the New York Academy of Sciences
Volume 1338, Issue 1, Pages 16-37
Publisher
Wiley
Online
2014-12-17
DOI
10.1111/nyas.12577
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates
- (2014) Marina A. Gruden et al. BEHAVIOURAL BRAIN RESEARCH
- Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease
- (2014) Cassia R. Overk et al. BIOCHEMICAL PHARMACOLOGY
- Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease
- (2014) Ian Martin et al. CELL
- Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
- (2014) P. Klein et al. EMBO JOURNAL
- The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
- (2014) Tom Cornelissen et al. HUMAN MOLECULAR GENETICS
- LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?
- (2014) Isabella Russo et al. Journal of Neuroinflammation
- Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain
- (2014) G. Piccoli et al. MOLECULAR AND CELLULAR BIOLOGY
- In vitro aggregation assays for the characterization of α-synuclein prion-like properties
- (2014) Joanna Narkiewicz et al. Prion
- Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation
- (2014) M. R. Ambroso et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling
- (2014) V. A. Morais et al. SCIENCE
- Parkin and mitochondrial quality control: toward assembling the puzzle
- (2014) Konstanze F. Winklhofer TRENDS IN CELL BIOLOGY
- Parkin and PINK1: much more than mitophagy
- (2014) Leslie A. Scarffe et al. TRENDS IN NEUROSCIENCES
- The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
- (2014) Senthilkumar S. Karuppagounder et al. Scientific Reports
- α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
- (2014) Hien T. Tran et al. Cell Reports
- Spread of neuronal degeneration in a dopaminergic,Lrrk-G2019Smodel of Parkinson disease
- (2013) Samantha J. Hindle et al. Autophagy
- The role of mitochondrial function and cellular bioenergetics in ageing and disease
- (2013) M.D. Brand et al. BRITISH JOURNAL OF DERMATOLOGY
- Chaperone-mediated autophagy: roles in disease and aging
- (2013) Ana Maria Cuervo et al. CELL RESEARCH
- Parkinson's Disease: From Genetics to Treatments
- (2013) Hueng-Chuen Fan et al. CELL TRANSPLANTATION
- Modeling dyskinesia in animal models of Parkinson disease
- (2013) Nicolas Morin et al. EXPERIMENTAL NEUROLOGY
- Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits
- (2013) Patrick J. Schultheis et al. HUMAN MOLECULAR GENETICS
- Mutation in theSYNJ1Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism
- (2013) Marialuisa Quadri et al. HUMAN MUTATION
- The Sac1 Domain ofSYNJ1Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures
- (2013) Catharine E. Krebs et al. HUMAN MUTATION
- Mutations in the Intellectual Disability Gene Ube2a Cause Neuronal Dysfunction and Impair Parkin-Dependent Mitophagy
- (2013) Dominik M. Haddad et al. MOLECULAR CELL
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss
- (2013) Yunjong Lee et al. NATURE NEUROSCIENCE
- Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies
- (2013) Elvira Valera et al. PHARMACOLOGY & THERAPEUTICS
- Near-Infrared 808 nm Light Boosts Complex IV-Dependent Respiration and Rescues a Parkinson-Related pink1 Model
- (2013) Melissa Vos et al. PLoS One
- Modeling Parkinson's Disease in Primates: The MPTP Model
- (2013) G. Porras et al. Cold Spring Harbor Perspectives in Medicine
- Genetics of Parkinson's Disease
- (2013) C. Klein et al. Cold Spring Harbor Perspectives in Medicine
- Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants
- (2013) Giovanni Esposito et al. PLoS Genetics
- Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
- (2013) Jiajie Diao et al. eLife
- The synaptic function of LRRK2
- (2012) Seongsoo Lee et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models
- (2012) Nian Xiong et al. CRITICAL REVIEWS IN TOXICOLOGY
- parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress
- (2012) A. Vincent et al. HUMAN MOLECULAR GENETICS
- Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation
- (2012) M. J. Diogenes et al. JOURNAL OF NEUROSCIENCE
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- Systematic Mutagenesis of -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
- (2012) J. Burre et al. JOURNAL OF NEUROSCIENCE
- Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress
- (2012) Elzbieta Janda et al. MOLECULAR NEUROBIOLOGY
- Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies
- (2012) Erwan Bezard et al. MOVEMENT DISORDERS
- LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis
- (2012) Samer Matta et al. NEURON
- A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice
- (2012) Marie-Francoise Chesselet et al. Neurotherapeutics
- Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
- (2012) Elodie Angot et al. PLoS One
- Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease
- (2012) M. W. C. Rousseaux et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
- (2012) B. Dehay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency
- (2012) M. Vos et al. SCIENCE
- Alpha-synuclein: from secretion to dysfunction and death
- (2012) O Marques et al. Cell Death & Disease
- Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1
- (2012) Derya R. Shimshek et al. Scientific Reports
- The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants
- (2012) Sven Vilain et al. PLoS Genetics
- Recent Advances in the Genetics of Parkinson's Disease
- (2011) Ian Martin et al. Annual Review of Genomics and Human Genetics
- α-Synuclein misfolding and Parkinson's disease
- (2011) Leonid Breydo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Parkinsonian Rotenone Mouse Model: Reevaluation of Long-Term Administration of Rotenone in C57BL/6 Mice
- (2011) Masatoshi Inden et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease
- (2011) Susan Duty et al. BRITISH JOURNAL OF PHARMACOLOGY
- PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
- (2011) Joo-Ho Shin et al. CELL
- Rotenone, Paraquat, and Parkinson’s Disease
- (2011) Caroline M. Tanner et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
- (2011) Nickie C. Chan et al. HUMAN MOLECULAR GENETICS
- Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane
- (2011) Saori R. Yoshii et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool
- (2011) G. Piccoli et al. JOURNAL OF NEUROSCIENCE
- Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease
- (2011) S. Z. Imam et al. JOURNAL OF NEUROSCIENCE
- Prion-like acceleration of a synucleinopathy in a transgenic mouse model
- (2011) Anne-Laure Mougenot et al. NEUROBIOLOGY OF AGING
- Rotenone induces degeneration of photoreceptors and impairs the dopaminergic system in the rat retina
- (2011) Julián Esteve-Rudd et al. NEUROBIOLOGY OF DISEASE
- Use of viral vectors to create animal models for Parkinson's disease
- (2011) Karin Löw et al. NEUROBIOLOGY OF DISEASE
- What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease
- (2011) Olga Corti et al. PHYSIOLOGICAL REVIEWS
- Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
- (2011) David Ramonet et al. PLoS One
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
- (2011) W. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clinical review of treatment options for select nonmotor symptoms of Parkinson's disease
- (2010) Lindy D. Wood et al. American Journal Geriatric Pharmacotherapy
- SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease
- (2010) Pablo Garcia-Reitböck et al. BRAIN
- The role of alpha-synuclein in neurotransmission and synaptic plasticity
- (2010) Furong Cheng et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S
- (2010) X. Li et al. JOURNAL OF NEUROSCIENCE
- A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
- (2010) Barry J. Snow et al. MOVEMENT DISORDERS
- Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
- (2010) Stephan Gehrke et al. NATURE
- Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
- (2010) Venu M. Nemani et al. NEURON
- The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway
- (2010) Angela C. Poole et al. PLoS One
- Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction
- (2010) F. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
- (2010) E. Ziviani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
- (2010) H. S. Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
- (2010) L.-Y. Hao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
- (2009) Juliane Neumann et al. BRAIN
- Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin
- (2009) L S Tain et al. CELL DEATH AND DIFFERENTIATION
- Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
- (2009) Vanessa A. Morais et al. EMBO Molecular Medicine
- Parkinson's disease: from monogenic forms to genetic susceptibility factors
- (2009) S. Lesage et al. HUMAN MOLECULAR GENETICS
- LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
- (2009) Javier Alegre-Abarrategui et al. HUMAN MOLECULAR GENETICS
- Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant -Synuclein
- (2009) X.-H. Lu et al. JOURNAL OF NEUROSCIENCE
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
- (2009) Aaron D Gitler et al. NATURE GENETICS
- Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
- (2009) Yanping Li et al. NATURE NEUROSCIENCE
- Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
- (2009) Xian Lin et al. NEURON
- Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?
- (2009) Vladimir L. Buchman et al. NEUROTOXICITY RESEARCH
- Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism
- (2009) Amy B. Manning-Boğ et al. NEUROTOXICOLOGY
- A review of Parkinson's disease
- (2008) C. A. Davie BRITISH MEDICAL BULLETIN
- The mitochondrial serine protease HtrA2/Omi: an overview
- (2008) L Vande Walle et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response
- (2008) N Moisoi et al. CELL DEATH AND DIFFERENTIATION
- A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans
- (2008) Tomoki Kuwahara et al. HUMAN MOLECULAR GENETICS
- Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy
- (2008) Tomohiro Kabuta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Effects of UCH-L1 on α-synuclein over-expression mouse model of Parkinson’s disease
- (2008) Toru Yasuda et al. JOURNAL OF NEUROCHEMISTRY
- Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson's disease
- (2008) Patricia K. Sonsalla et al. PARKINSONISM & RELATED DISORDERS
- Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
- (2008) C. A. Gautier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started