CXCR4-directed theranostics in oncology and inflammation

Potential influence of concomitant chemotherapy on CXCR4 expression in receptor directed endoradiotherapy

(2018) Constantin Lapa et al.   BRITISH JOURNAL OF HAEMATOLOGY

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

[68Ga]Ga-Pentixafor PET/MRI for CXCR4 Imaging of Chronic Lymphocytic Leukemia

(2018) Marius E. Mayerhoefer et al.   INVESTIGATIVE RADIOLOGY

Feasibility of CXCR4-directed radioligand therapy in advanced diffuse large B cell lymphoma

(2018) Constantin Lapa et al.   JOURNAL OF NUCLEAR MEDICINE

Anti-Inflammatory Effects on Atherosclerotic Lesions Induced by CXCR4-Directed Endoradiotherapy

(2018) Xiang Li et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Imaging of C-X-C Motif Chemokine Receptor CXCR4 Expression After Myocardial Infarction With [ 68 Ga]Pentixafor-PET/CT in Correlation With Cardiac MRI

(2018) Theresa Reiter et al.   JACC-Cardiovascular Imaging

Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics

(2018) Stefan Habringer et al.   Theranostics

Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies

(2018) Ilaria Laurenzana et al.   Stem Cells International

CXCR4 involvement in neurodegenerative diseases

(2018) Luke W. Bonham et al.   Translational Psychiatry

The gross picture: intraindividual tumour heterogeneity in a patient with nonsecretory multiple myeloma

(2017) Constantin Lapa et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Structure–Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist

(2017) Salvatore Di Maro et al.   JOURNAL OF MEDICINAL CHEMISTRY

68Ga-Pentixafor PET/CT Imaging of Chemokine Receptor CXCR4 in Chronic Infection of the Bone: First Insights

(2017) Caroline Bouter et al.   JOURNAL OF NUCLEAR MEDICINE

Integrating MRI and Chemokine Receptor CXCR4-Targeted PET for Detection of Leukocyte Infiltration in Complicated Urinary Tract Infections After Kidney Transplantation

(2017) Thorsten Derlin et al.   JOURNAL OF NUCLEAR MEDICINE

Clinical Molecular Imaging of Chemokine Receptor CXCR4 Expression in Atherosclerotic Plaque Using68Ga-Pentixafor PET: Correlation with Cardiovascular Risk Factors and Calcified Plaque Burden

(2017) Desiree Weiberg et al.   JOURNAL OF NUCLEAR MEDICINE

Targeting CXCR4 with [68Ga]Pentixafor: a suitable theranostic approach in pleural mesothelioma?

(2017) Constantin Lapa et al.   Oncotarget

Targeting CXCR4 reverts the suppressive activity of T-regulatory cells in renal cancer

(2017) Sara Santagata et al.   Oncotarget

[177Lu]pentixather: Comprehensive Preclinical Characterization of a First CXCR4-directed Endoradiotherapeutic Agent

(2017) Margret Schottelius et al.   Theranostics

CXCR4-directed endoradiotherapy induces high response rates in extramedullary relapsed Multiple Myeloma

(2017) Constantin Lapa et al.   Theranostics

[68Ga]Pentixafor-PET/CT for imaging of chemokine receptor CXCR4 expression in multiple myeloma - Comparison to [18F]FDG and laboratory values

(2017) Constantin Lapa et al.   Theranostics

Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors - a Triple Tracer Comparative Approach

(2017) Rudolf A. Werner et al.   Theranostics

Response assessment with the CXCR4-directed positron emission tomography tracer [68Ga]Pentixafor in a patient with extranodal marginal zone lymphoma of the orbital cavities

(2017) Peter Herhaus et al.   EJNMMI Research

A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion

(2016) Raffaela Fontanella et al.   CANCER LETTERS

[68Ga]Pentixafor–Positron Emission Tomography/Computed Tomography Detects Chemokine Receptor CXCR4 Expression After Ischemic Stroke

(2016) Jan Stefan Schmid et al.   Circulation-Cardiovascular Imaging

Molecular Imaging of Chemokine Receptor CXCR4 in Non–Small Cell Lung Cancer Using 68Ga-Pentixafor PET/CT

(2016) Thorsten Derlin et al.   CLINICAL NUCLEAR MEDICINE

Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia

(2016) P. Herhaus et al.   HAEMATOLOGICA

Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists

(2016) Salvatore Di Maro et al.   JOURNAL OF MEDICINAL CHEMISTRY

First Experience with Chemokine Receptor CXCR4-Targeted PET Imaging of Patients with Solid Cancers

(2016) T. Vag et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer 68 Ga-Pentixafor for PET

(2016) Fabien Hyafil et al.   JOURNAL OF NUCLEAR MEDICINE

A New Anti-CXCR4 Antibody That Blocks the CXCR4/SDF-1 Axis and Mobilizes Effector Cells

(2016) M. Broussas et al.   MOLECULAR CANCER THERAPEUTICS

N-[11C]Methyl-AMD3465 PET as a Tool for In Vivo Measurement of Chemokine Receptor 4 (CXCR4) Occupancy by Therapeutic Drugs

(2016) S. V. Hartimath et al.   MOLECULAR IMAGING AND BIOLOGY

CXCR4-antagonist Peptide R-liposomes for combined therapy against lung metastasis

(2016) Caterina Ieranò et al.   Nanoscale

Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies

(2016) Sheng-Bin Peng et al.   PLoS One

[68Ga]Pentixafor-PET/CT for imaging of chemokine receptor 4 expression in small cell lung cancer - initial experience

(2016) Constantin Lapa et al.   Oncotarget

CXCR4 antagonists suppress small cell lung cancer progression

(2016) Sanaz Taromi et al.   Oncotarget

Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia

(2016) P. Herhaus et al.   HAEMATOLOGICA

The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity

(2016) Andreas Poschenrieder et al.   EJNMMI Research

Preclinical evaluation of [68Ga]NOTA-pentixafor for PET imaging of CXCR4 expression in vivo — a comparison to [68Ga]pentixafor

(2016) Andreas Poschenrieder et al.   EJNMMI Research

Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4+ T cells and disease activity

(2016) Yasuo Nagafuchi et al.   Scientific Reports

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

(2015) B.-S. Cho et al.   BLOOD

Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment

(2015) S. Scala   CLINICAL CANCER RESEARCH

In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma

(2015) K. Philipp-Abbrederis et al.   EMBO Molecular Medicine

Upregulated myocardial CXCR4-expression after myocardial infarction assessed by simultaneous GA-68 pentixafor PET/MRI

(2015) C. Rischpler et al.   JOURNAL OF NUCLEAR CARDIOLOGY

First-in-Human Experience of CXCR4-Directed Endoradiotherapy with 177Lu- and 90Y-Labeled Pentixather in Advanced-Stage Multiple Myeloma with Extensive Intra- and Extramedullary Disease

(2015) K. Herrmann et al.   JOURNAL OF NUCLEAR MEDICINE

Biodistribution and Radiation Dosimetry for the Chemokine Receptor CXCR4-Targeting Probe 68Ga-Pentixafor

(2015) K. Herrmann et al.   JOURNAL OF NUCLEAR MEDICINE

CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer

(2015) J. Xiang et al.   MOLECULAR CANCER THERAPEUTICS

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

(2015) F Guo et al.   ONCOGENE

Concise Review: CXCR4/CXCL12 Signaling in Immature Hematopoiesis-Lessons From Pharmacological and Genetic Models

(2015) Darja Karpova et al.   STEM CELLS

PET Imaging of Leukocytes in Patients With Acute Myocardial Infarction ∗

(2015) Matthias Nahrendorf et al.   JACC-Cardiovascular Imaging

Molecular Imaging of the Chemokine Receptor CXCR4 After Acute Myocardial Infarction

(2015) James T. Thackeray et al.   JACC-Cardiovascular Imaging

[ 68 Ga]Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression After Myocardial Infarction

(2015) Constantin Lapa et al.   JACC-Cardiovascular Imaging

Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms

(2015) Daniel Kaemmerer et al.   Oncotarget

POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL

(2015) Edward Allan R. Sison et al.   Oncotarget

Prospective Study of 68Ga-NOTA-NFB: Radiation Dosimetry in Healthy Volunteers and First Application in Glioma Patients

(2015) Zhe Wang et al.   Theranostics

Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging

(2015) Hans Jürgen Wester et al.   Theranostics

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives

(2015) Lukas Pawig et al.   Frontiers in Immunology

Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises

(2015) Guillaume Pierre Charles George et al.   Molecular Imaging

Identification of LY2510924, a Novel Cyclic Peptide CXCR4 Antagonist That Exhibits Antitumor Activities in Solid Tumor and Breast Cancer Metastatic Models

(2014) S.-B. Peng et al.   MOLECULAR CANCER THERAPEUTICS

Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML In Vitro and In Vivo

(2014) K. Beider et al.   MOLECULAR CANCER THERAPEUTICS

Evaluation of N-[11C]Methyl-AMD3465 as a PET Tracer for Imaging of CXCR4 Receptor Expression in a C6 Glioma Tumor Model

(2014) S. V. Hartimath et al.   MOLECULAR PHARMACEUTICS

Targeting CXCR4 with CTCE-9908 inhibits prostate tumor metastasis

(2014) Donald Wong et al.   BMC Urology

Preclinical evaluation of a CXCR4-specific 68Ga-labelled TN14003 derivative for cancer PET imaging

(2013) Guillaume P.C. George et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The High-Affinity CXCR4 Antagonist BKT140 Is Safe and Induces a Robust Mobilization of Human CD34+ Cells in Patients with Multiple Myeloma

(2013) A. Peled et al.   CLINICAL CANCER RESEARCH

CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia

(2013) Ye Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Scavenging strategy for specific activity improvement: application to a new CXCR4-specific cyclopentapeptide positron emission tomography tracer

(2013) Guillaume P. C. George et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor

(2013) D Karpova et al.   LEUKEMIA

[99mTc]O2-AMD3100 as a SPECT tracer for CXCR4 receptor imaging

(2013) Siddesh V. Hartimath et al.   NUCLEAR MEDICINE AND BIOLOGY

The CXCR4 Antagonist AMD3465 Regulates Oncogenic Signaling and Invasiveness In Vitro and Prevents Breast Cancer Growth and Metastasis In Vivo

(2013) Xiaoyang Ling et al.   PLoS One

Molecular Imaging of Chemokine Receptor CXCR4

(2013) Ido. D. Weiss et al.   Theranostics

Halting metastasis through CXCR4 inhibition

(2012) Deborah M. Ramsey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia

(2012) Michael Quante et al.   CANCER CELL

BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Antitumor Activity In Vivo in Hematologic Malignancies

(2012) M. R. Kuhne et al.   CLINICAL CANCER RESEARCH

A review on CXCR4/CXCL12 axis in oncology: No place to hide

(2012) Urszula M. Domanska et al.   EUROPEAN JOURNAL OF CANCER

In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non–small cell lung cancer

(2012) Duha Fahham et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Development of a Unique Small Molecule Modulator of CXCR4

(2012) Zhongxing Liang et al.   PLoS One

Synthesis and Evaluation of a Bimodal CXCR4 Antagonistic Peptide

(2011) Joeri Kuil et al.   BIOCONJUGATE CHEMISTRY

CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target

(2011) Mizuhiko Terasaki et al.   Brain Tumor Pathology

PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand

(2011) Oliver Demmer et al.   ChemMedChem

CXCL12 (SDF1 )-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?

(2011) D. G. Duda et al.   CLINICAL CANCER RESEARCH

Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4

(2011) Oliver Demmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Imaging CXCR4 Expression in Human Cancer Xenografts: Evaluation of Monocyclam 64Cu-AMD3465

(2011) R. A. De Silva et al.   JOURNAL OF NUCLEAR MEDICINE

PET of CXCR4 Expression by a 68Ga-Labeled Highly Specific Targeted Contrast Agent

(2011) E. Gourni et al.   JOURNAL OF NUCLEAR MEDICINE

Hybrid Peptide Dendrimers for Imaging of Chemokine Receptor 4 (CXCR4) Expression

(2011) Joeri Kuil et al.   MOLECULAR PHARMACEUTICS

Molecular Imaging of CXCR4 Receptor Expression in Human Cancer Xenografts with [64Cu]AMD3100 Positron Emission Tomography

(2010) S. Nimmagadda et al.   CANCER RESEARCH

PET of Tumor CXCR4 Expression with 4-18F-T140

(2010) O. Jacobson et al.   JOURNAL OF NUCLEAR MEDICINE

Multiple functions of CXCL12 in a syngeneic model of breast cancer

(2010) Sharon A Williams et al.   Molecular Cancer

FDA Review Summary: Mozobil in Combination with Granulocyte Colony-Stimulating Factor to Mobilize Hematopoietic Stem Cells to the Peripheral Blood for Collection and Subsequent Autologous Transplantation

(2010) Michael Brave et al.   ONCOLOGY

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4

(2009) Veronique Bodart et al.   BIOCHEMICAL PHARMACOLOGY

64Cu-AMD3100—A novel imaging agent for targeting chemokine receptor CXCR4

(2009) Orit Jacobson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fluorescent imaging of high-grade bladder cancer using a specific antagonist for chemokine receptor CXCR4

(2009) Koji Nishizawa et al.   INTERNATIONAL JOURNAL OF CANCER

Chemokine-like functions of MIF in atherosclerosis

(2008) Andreas Schober et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Introduction of Functional Groups into Peptides viaN-Alkylation

(2008) O. Demmer et al.   ORGANIC LETTERS