Review
Oncology
Xianxian Wu, Hongdian Zhang, Zhilin Sui, Yang Wang, Zhentao Yu
Summary: Esophageal squamous cell carcinoma is the main type of esophageal cancer, where abnormal expression of CXCL12 and CXCR4 contributes to tumor proliferation, distant metastases, and worsening prognosis. Antagonists and imaging agents targeting CXCL12/CXCR4 have been developed to interfere with and monitor tumor metastasis.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Medicine, Research & Experimental
Weibo Feng, Wenjie Huang, Jie Chen, Chenyang Qiao, Danfei Liu, Xiaoyu Ji, Meng Xie, Tongyue Zhang, Yijun Wang, Mengyu Sung, Dean Tian, Daiming Fan, Yongzhan Nie, Kaichun Wu, Limin Xia
Summary: HOXB5 gene plays a crucial role in promoting colorectal cancer metastasis by transactivating metastatic related genes CXCR4 and ITGB3. Additionally, a positive feedback loop of CXCL12-HOXB5-CXCR4 has been identified to have an important role in colorectal cancer metastasis.
Article
Biotechnology & Applied Microbiology
Gaihong Ding, Jinhua An, Luyao Li
Summary: Research has found that miR-103a-3p exacerbates renal cell damage caused by sepsis by targeting CXCL12.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas K. Buck, Alexander Haug, Niklas Dreher, Alessandro Lambertini, Takahiro Higuchi, Constantin Lapa, Alexander Weich, Martin G. Pomper, Hans-Juergen Wester, Anja Zehndner, Andreas Schirbel, Samuel Samnick, Marcus Hacker, Verena Pichler, Stefanie Hahner, Martin Fassnacht, Hermann Einsele, Sebastian E. Serfling, Rudolf A. Werner
Summary: In recent years, molecular imaging targeting CXCR4 has been increasingly used in various clinical settings. This study aimed to assess radiopharmaceutical uptake and image contrast to determine the clinical applications for CXCR4-directed imaging and investigate the impact of specific activity on scan contrast.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas K. Buck, Sebastian E. Serfling, Sabrina Kraus, Samuel Samnick, Niklas Dreher, Takahiro Higuchi, Leo Rasche, Hermann Einsele, Rudolf A. Werner
Summary: This article discusses the novel and established radiopharmaceuticals used for treating hematologic neoplasms, the use of small molecules specifically binding to C-X-C motif chemokine receptor 4 as theranostic agents, and the advantages and disadvantages of lymphoma treatment using radioimmunoconjugates.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shabnam Babazadeh, Seyed Mahdi Nassiri, Vahid Siavashi, Mohadeseh Sahlabadi, Mostafa Hajinasrollah, Mohamad Zamani-Ahmadmahmudi
Summary: The study reveals the impact of MSC-derived CXCL12 on macrophage phenotypic switching towards M2, influencing their function in tumorigenesis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas K. Buck, Goetz Ulrich Grigoleit, Sabrina Kraus, Andreas Schirbel, Michael Heinsch, Niklas Dreher, Takahiro Higuchi, Constantin Lapa, Heribert Haenscheid, Samuel Samnick, Hermann Einsele, Sebastian E. Serfling, Rudolf A. Werner
Summary: In this study, we investigated the use of CXCR4-targeted radioligand therapy (RLT) as a conditioning regimen for hematopoietic stem cell transplantation (HSCT) in patients with advanced T-cell lymphoma. The results showed that CXCR4-directed RLT can be an effective treatment option, leading to remarkable antilymphoma activity in selected cases.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yaru Yang, Jiayan Li, Wangrui Lei, Haiying Wang, Yunfeng Ni, Yanqing Liu, Huanle Yan, Yifan Tian, Zheng Wang, Zhi Yang, Shulin Yang, Yang Yang, Qiang Wang
Summary: Cancer is a complex disease caused by genetic mutations and/or epigenetic changes, and it poses the biggest challenge worldwide. Cytokines, particularly chemokines, play a significant role in various human cancers by affecting homeostasis, immune function, and facilitating cancer development stages such as invasion, metastasis, and angiogenesis. Specifically, chemokines such as CXCL12 and its receptors CXCR4 and CXCR7 exert extensive influence on tumor cell behavior, including proliferation, survival, angiogenesis, metastasis, and tumor microenvironment, making them crucial players in the initiation and progression of cancers such as leukemia, breast cancer, lung cancer, prostate cancer, and multiple myeloma. This review aims to summarize the recent research progress and future challenges related to the CXCL12-CXCR4/CXCR7 signaling axis in cancer, emphasizing the potential of utilizing CXCL12-CXCR4/CXCR7 as a biomarker or therapeutic target for cancer treatment and providing valuable insights for the development of targeted cancer therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Paola Antonello, Diego U. Pizzagalli, Mathilde Foglierini, Serena Melgrati, Egle Radice, Sylvia Thelen, Marcus Thelen
Summary: Chemotaxis is an essential process in tumors metastasis, and in this study, ACKR3 was found to control the migration of lymphoma cells in response to CXCL12. The interaction between LTB4 and CXCL12 enhances the migration of lymphoma cells, providing a novel mechanism for cell-to-cell-induced migration.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Wenjin Liu, Lulu Wang, Xiurong Li, Chaoqing Gao, Jianmei Zhou, Jiajun Zhou, Liang Wang, Zhuxing Sun, Hong Chu, Wei Fan, Youwei Bai, Junwei Yang
Summary: The study identified CXCL16 as a potent predictor for all-cause mortality and cardiovascular events in dialysis patients. Compared to IL-6 and CRP, CXCL16 showed stronger predictive power and was an independent predictor after adjusting for covariates.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Bo Gao, Guomin Sun, Yan Wang, Yaqin Geng, Lei Zhou, Xi Chen
Summary: Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disorder, and miR-23 inhibits inflammation in RA by regulating CXCL12 through the NF-kappa B signaling pathway, serving as a potential target for the diagnosis and treatment of RA.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Isabel Hamshaw, Marco M. D. Cominetti, Wing-Yee Lai, Mark Searcey, Anja Mueller
Summary: Cancer metastasis is a major cause of cancer-related death. The CXCR4 receptor and its ligand CXCL12 play important roles in promoting metastasis, making them attractive therapeutic targets. In this study, a novel CXCR4 antagonist was developed and used for CXCR4-based imaging. The results showed that these antagonists were non-toxic and effectively inhibited cancer cell migration and calcium release.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medical Laboratory Technology
Shao-Wei Zheng, Chun-Han Sun, Zhi-Jia Wen, Wei-Le Liu, Xu Li, Tian-Yu Chen, Yu-Cong Zou, Hao-Bo Zhong, Zhan-Jun Shi
Summary: This study found that serum CXCL12 levels were negatively associated with disease severity in patients with non-traumatic ONFH and may serve as a favorable marker for FICAT grading.
CLINICA CHIMICA ACTA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Philipp E. Hartrampf, Aleksander Kosmala, Sebastian E. Serfling, Lena Bundschuh, Takahiro Higuchi, Constantin Lapa, Steven P. Rowe, Yohji Matsusaka, Alexander Weich, Andreas K. Buck, Ralph A. Bundschuh, Rudolf A. Werner
Summary: In this study, we evaluated the agreement rates between observers in patients scanned with CXCR4-targeted PET/CT, including the percentage of patients eligible for CXCR4-targeted RLT based on the scan results. Fair to excellent agreement rates were observed for both visual and quantitative assessments, indicating the potential widespread adoption of [Ga-68]pentixafor in the clinic.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Cell Biology
Liam A. Ridge, Dania Kewbank, Dagmar Schuetz, Ralf Stumm, Peter J. Scambler, Sarah Ivins
Summary: The study shows that CXCL12 signaling through its receptor CXCR4 plays distinct roles in different stages of SLV development, guiding cellular distribution and regulating cell proliferation. The atypical chemokine receptor CXCR7 may have a role in regulating ligand bioavailability during SLV morphogenesis.
Review
Pharmacology & Pharmacy
Giulia Assoni, Valeria La Pietra, Rosangela Digilio, Caterina Ciani, Nausicaa Valentina Licata, Mariachiara Micaelli, Elisa Facen, Weronika Tomaszewska, Linda Cerofolini, Anna Perez-Rafols, Marta Varela Rey, Marco Fragai, Ashwin Woodhoo, Luciana Marinelli, Daniela Arosio, Isabelle Bonomo, Alessandro Provenzani, Pierfausto Seneci
Summary: The article provides an overview of the role and mechanisms of the Human antigen R (HuR) protein in RNA maturation and processing, as well as its significance and clinical applications in oncology and inflammation.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Oncology
Caterina Ierano, Dario Righelli, Crescenzo D'Alterio, Maria Napolitano, Luigi Portella, Giuseppina Rea, Federica Auletta, Sara Santagata, Anna Maria Trotta, Giuseppe Guardascione, Federica Liotti, Nella Prevete, Piera Maiolino, Antonio Luciano, Antonio Barbieri, Annabella Di Mauro, Cristin Roma, Riziero Esposito Abate, Fabiana Tatangelo, Roberto Pacelli, Nicola Normanno, Rosa Marina Melillo, Stefania Scala
Summary: The study found that in PD-1 positive colorectal cancer cells, the anti-PD-1 nivolumab (NIVO) activates tumor survival pathways and protects tumor cells from conventional therapies. These findings highlight the important role of PD-1 in the development of colorectal cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Crescenzo D'Alterio, Anna Spina, Laura Arenare, Paolo Chiodini, Maria Napolitano, Francesca Galdiero, Luigi Portella, Vittorio Simeon, Simona Signoriello, Francesco Raspagliesi, Domenica Lorusso, Carmela Pisano, Nicoletta Colombo, Gian Franco Zannoni, Nunzia Simona Losito, Rossella De Cecio, Giosue Scognamiglio, Daniela Califano, Daniela Russo, Valentina Tuninetti, Maria Carmela Piccirillo, Piera Gargiulo, Francesco Perrone, Sandro Pignata, Stefania Scala
Summary: Despite advances in research on epithelial ovarian cancer, this study systematically evaluated the CXCR4-CXCL12-CXCR7 axis in tumor and stromal cells, identifying a potential prognostic and therapeutic target in high CXCL12 expression in cancer cells. The study highlights the importance of further investigating the CXCL12 axis to improve treatment efficacy in EOC patients.
Article
Biochemistry & Molecular Biology
Stefano Tomassi, Caterina Ierano, Alessandra Del Bene, Antonia D'Aniello, Maria Napolitano, Giuseppina Rea, Federica Auletta, Luigi Portella, Anna Capiluongo, Vincenzo Mazzarella, Rosita Russo, Angela Chambery, Stefania Scala, Salvatore Di Maro, Anna Messere
Summary: Synthetic nucleic acid interactors have exciting biotechnological and potential therapeutic applications. This study focuses on the synthesis of homo-thymine nucleopeptides and investigates the influence of underivatized amino acid residues and the distance between the nucleobase and peptide backbone on nucleic acid recognition. The results show that two of the nucleopeptides can efficiently bind DNA and RNA targets and cross membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Crescenzo D'Alterio, Alessandro Giardino, Giosue Scognamiglio, Giovanni Butturini, Luigi Portella, Giuseppe Guardascione, Isabella Frigerio, Marco Montella, Stefano Gobbo, Guido Martignoni, Vincenzo Napolitano, Ferdinando De Vita, Fabiana Tatangelo, Renato Franco, Stefania Scala
Summary: CXCR4-CXCL12 evaluation in PDAC identifies prognostic categories and could guide therapeutic approaches.
Article
Biochemistry & Molecular Biology
Maria Maisto, Vincenzo Piccolo, Ettore Novellino, Elisabetta Schiano, Fortuna Iannuzzo, Roberto Ciampaglia, Vincenzo Summa, Gian Carlo Tenore
Summary: The study optimized the extraction process of Ursolic acid (UA) from Annurca apple (AA) using sunflower oil as a solvent, and identified twenty-three phenolic and terpenoid molecules in the extract. The optimized extract, named Optimized Annurca Apple Oleolyte (OAAO), showed significant antioxidant activity and could be considered a safe and functional ingredient for cosmetic formulations.
Review
Biochemistry & Molecular Biology
Maria Maisto, Fortuna Iannuzzo, Ettore Novellino, Elisabetta Schiano, Vincenzo Piccolo, Gian Carlo Tenore
Summary: Urinary tract infections (UTIs) are a common bacterial infection, especially in women. The main etiological agents are E. coli, Pseudomonas aeruginosa, and Proteus mirabilis. Due to the increase in antimicrobial resistance, there is a need for natural alternatives for UTI treatment. This review summarizes the potential therapeutic effects of natural polyphenol-based nutraceuticals and foods through in vitro and in vivo studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Francesco Fiorentino, Sara Sementilli, Martina Menna, Federica Turrisi, Stefano Tomassi, Francesca Romana Pellegrini, Angela Iuzzolino, Francesca D'Acunzo, Alessandra Feoli, Hannah Wapenaar, Sophie Taraglio, Caterina Fraschetti, Donatella Del Bufalo, Gianluca Sbardella, Frank J. Dekker, Alessandro Paiardini, Daniela Trisciuoglio, Antonello Mai, Dante Rotili
Summary: KAT8, a lysine acetyltransferase, is involved in the development and metastasis of various cancer types. Two newly developed compounds, 19 and 34, are selective KAT8 inhibitors with low-micromolar activity and show antiproliferative effects in cancer cell lines, while not affecting nontransformed cells. These compounds provide valuable tools for studying KAT8 biology and have potential for further optimization studies.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Acoustics
Alessandra Del Bene, Antonia D'Aniello, Stefano Tomassi, Francesco Merlino, Vincenzo Mazzarella, Rosita Russo, Angela Chambery, Sandro Cosconati, Salvatore Di Maro, Anna Messere
Summary: We developed an innovative and easily accessible solid-phase synthetic protocol for PNA oligomers by investigating the ultrasonication effects. This approach improved the crude product purities and the isolated yields of different types of PNA.
ULTRASONICS SONOCHEMISTRY
(2023)
Review
Oncology
Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Anna Maria Trotta, Francesco Izzo, Francesco Perri, Marco Cascella, Francesco Sabbatino, Vincenza Granata, Marco Correra, Luca Tarotto, Salvatore Stilo, Francesco Fiore, Nicola Martucci, Antonello La Rocca, Carmine Picone, Paolo Muto, Valentina Borzillo, Andrea Belli, Renato Patrone, Edoardo Mercadante, Fabiana Tatangelo, Gerardo Ferrara, Annabella Di Mauro, Giosue Scognamiglio, Massimiliano Berretta, Maurizio Capuozzo, Angela Lombardi, Jerome Galon, Oreste Gualillo, Ugo Pace, Paolo Delrio, Giovanni Savarese, Stefania Scala, Guglielmo Nasti, Michele Caraglia
Summary: Oligometastatic disease is a condition in which cancer spreads to only a few distant sites, and it is associated with a more favorable prognosis compared to polymetastatic disease. Recent studies have identified specific molecular and genetic features that underlie the oligometastatic phenotype, suggesting the potential for personalized therapies. This scoping review highlights new clinical, biological, and methodological challenges in understanding and treating oligometastatic disease.
Article
Food Science & Technology
Elisabetta Schiano, Ilaria Neri, Maria Maisto, Ettore Novellino, Fortuna Iannuzzo, Vincenzo Piccolo, Vincenzo Summa, Lucia Grumetto, Gian Carlo Tenore
Summary: This study developed and validated a method for measuring abscisic acid (ABA) in biological samples using liquid-liquid extraction and liquid mass spectrometry. The researchers found that ABA plays a role in regulating glucose homeostasis in humans, as evidenced by its increase after consuming a standardized test meal. This finding is important for the treatment and monitoring of individuals with dysglycemia.
Article
Chemistry, Medicinal
Michele Roggia, Benito Natale, Giorgio Amendola, Salvatore Di Maro, Sandro Cosconati
Summary: This research introduces a novel computational protocol called PyRMD2Dock, which combines the Ligand-Based Virtual Screening (LBVS) tool PyRMD with the popular docking software AutoDock-GPU (AD4-GPU), to enhance the throughput of virtual screening campaigns for drug discovery. By implementing PyRMD2Dock, it is possible to rapidly screen massive chemical databases and identify compounds with the highest predicted binding affinity to a target protein. The study showcases the value of combining AI-powered LBVS tools with docking software for effective and high-throughput virtual screening of ultralarge molecular databases in drug discovery. PyRMD and the PyRMD2Dock protocol are freely available on GitHub (https://github.com/cosconatilab/PyRMD) as an open-source tool.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Vincenzo Maria D'Amore, Greta Donati, Elena Lenci, Beatrice Stefanie Ludwig, Susanne Kossatz, Monica Baiula, Andrea Trabocchi, Horst Kessler, Francesco Saverio Di Leva, Luciana Marinelli
Summary: In this study, the binding affinity of the peptide iRGD with cancer-related integrins, including αvβ3, αvβ5, and αvβ6, was re-evaluated. The conformation of iRGD in solution and its binding mechanism to integrin partners were investigated through simulations and calculations. Suggestions for improving its tumor-homing properties were provided.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Biochemistry & Molecular Biology
Greta Donati, Vincenzo Maria D'Amore, Pasquale Russomanno, Linda Cerofolini, Jussara Amato, Simona Marzano, Maria Salobehaj, Domenico Rizzo, Giulia Assoni, Alfonso Carotenuto, Valeria La Pietra, Daniela Arosio, Pierfausto Seneci, Marco Fragai, Diego Brancaccio, Francesco Saverio Di Leva, Luciana Marinelli
Summary: The PD-1/PD-L1 axis is crucial in evading the immune system in cancers, and anti-PD-1/PD-L1 antibodies have been extensively studied in clinical trials. However, the development of small molecules as anti-PD-L1 drugs faces certain limitations. This study utilized theoretical and experimental approaches to gain insights into the molecular interactions between biphenyl-based compounds and human and murine PD-L1, providing valuable information for the design of next-generation anti-PD-L1 molecules.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Alfonso Carotenuto, Diego Brancaccio, Mariateresa Giustiniano, Rolando Cannalire, Federica Santoro, Camilla Russo, Giulia Graziani, Gian Cesare Tron
Summary: The merging of micellar and photoredox catalysis enables efficient photochemical transformations in water. This study presents a photomicellar catalyzed synthesis of amides with a wide substrate scope and good functional group tolerance. Additionally, solution NMR experiments with paramagnetic probes provide valuable insights into the reaction environment and the localization of the photocatalyst within the micelles.
ACS ORGANIC & INORGANIC AU
(2022)
