Article
Pharmacology & Pharmacy
Marina Guedes Fonseca de Souza, Fabricia Nunes de Jesus Guedes, Marli Luiza Tebaldi, Everton do Nascimento Alencar, Lucas Amaral-Machado, Eryvaldo Socrates Tabosa do Egito, Andre Luis Branco de Barros, Daniel Cristian Ferreira Soares
Summary: Stealth liposomes loaded with iron oxide were developed as a potential alternative for lung cancer treatment. These ferri-liposomes showed significant cytotoxicity against lung cancer cells but not normal cells, indicating a potential selectivity for lung tumors. Flow cytometry studies suggested that ferri-liposomes induce apoptosis/ferroptosis in A549 tumor cells by reducing mitochondrial membrane potential.
Article
Chemistry, Multidisciplinary
Abraham Akonnor, Masaki Makise, Akihiko Kuniyasu
Summary: A CXCR4-targeted antitumor peptidomimetic (CTCE-KLAK) was developed and showed cell-selective cytotoxicity against breast cancer cells and induced rapid necrotic cell death. In a mouse model, CTCE-KLAK significantly inhibited tumor growth and lung metastasis, highlighting its potential as a promising agent for treating triple-negative breast cancer.
Article
Cell Biology
Shiqing Liu, Chengping Hu, Min Li, Jian An, Wolong Zhou, Jia Guo, Yao Xiao
Summary: This study reveals that estrogen receptor beta promotes non-small-cell lung cancer cell invasion through regulating the circ-TMX4/miR-622/CXCR4 signaling pathway. These findings provide a new target for the development of treatment strategies to suppress lung cancer progression.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Jiachi Ma, Wanqing Liang, Yaosheng Qiang, Lei Li, Jun Du, Chengwu Pan, Bangling Chen, Chensong Zhang, Yuzhong Chen, Qingkang Wang
Summary: The study investigated the cooperative role of CXCR4/CXCL12 axis and IL-1Ra in the metastasis of colorectal cancer cells. It was found that IL-1 alpha and rIL-1 alpha promoted CXCL12 expression, while IL-1Ra inhibited this effect. Additionally, CXCL12 enhanced migration and proliferation of endothelial cells, and IL-1Ra inhibited migration, proliferation, and angiogenesis of colorectal cancer cells.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Chemistry, Medicinal
Iris Cadima-Couto, Alexandra Tauzin, Joao M. Freire, Tiago N. Figueira, Ruben D. M. Silva, Clara Perez-Peinado, Catarina Cunha-Santos, Ines Bartolo, Nuno Taveira, Lurdes Gano, Joao D. G. Correia, Joao Goncalves, Fabrizio Mammano, David Andreu, Miguel A. R. B. Castanho, Ana Salome Veiga
Summary: The anti-HIV-1 peptide pepRF1, derived from the Dengue virus capsid protein, shows promising inhibitory effects with a potential therapeutic window higher than 53,000. It specifically targets CXCR4-tropic strains, preventing viral entry into target cells by acting as an antagonist of the viral coreceptor CXCR4. Compared to T20, a peptide-based HIV-1 entry inhibitor, pepRF1 is more effective and can potentially be used alone or in combination with other anti-HIV drugs, as well as a novel therapeutic strategy for other CXCR4-related diseases.
ACS INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Jingjing Wang, Xiaoqiang Zheng, Xiao Fu, Aimin Jiang, Yu Yao, Wangxiao He
Summary: This article introduces a new method for the treatment of metastatic melanoma by using a bifunctional supramolecular peptide HBBplus@CA, which simultaneously inhibits both the Wnt/β-catenin and MAPK/ERK signaling pathways. It effectively suppresses melanoma cell proliferation, migration, and invasion, and inhibits lung metastasis and prolongs survival in a mouse model.
Article
Oncology
Ilya Turchin, Shazia Bano, Mikhail Kirillin, Anna Orlova, Valeriya Perekatova, Vladimir Plekhanov, Ekaterina Sergeeva, Daria Kurakina, Aleksandr Khilov, Alexey Kurnikov, Pavel Subochev, Marina Shirmanova, Anastasiya Komarova, Diana Yuzhakova, Alena Gavrina, Srivalleesha Mallidi, Tayyaba Hasan
Summary: A new approach of combined optoacoustic and fluorescence imaging was developed to trace photosensitizer kinetics and vascular effects in vivo. The study demonstrated the enhancement of photosensitizer accumulation in tumor and alterations in tumor vasculature structure after treatment. The results suggest that the multifunctional liposomal platform combined with multimodal imaging offers an efficient and personalized platform to improve cancer treatment outcomes.
Review
Engineering, Biomedical
Matthew R. Aronson, Scott H. Medina, Michael J. Mitchell
Summary: Loading chemotherapy drugs into liposomes can reduce toxicity in patients, but passive targeting issues remain. Modifying liposome surfaces allows for tumor targeting and controlled drug delivery. Peptides can be used as ligands for tumor cell localization.
APL BIOENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Wen Ting Zhu, Xiang Feng Zeng, Hua Yang, Meng Lei Jia, Wei Zhang, Wei Liu, Sheng Yao Liu
Summary: Folate-modified liposomes loaded with resveratrol were prepared and investigated for their anti-osteosarcoma effects in vitro and in vivo. The results showed that folate-modified liposomes significantly increased the uptake of resveratrol by osteosarcoma cells and inhibited tumor proliferation, migration, and induced apoptosis more effectively than free resveratrol and liposomes. This strategy has great potential for the treatment of osteosarcoma.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Dipankar Chaudhuri, Tiangong Lu, Binu Jacob, Sojan Abraham, Premlata Shankar, Michael A. Poss, Nouri Neamati, Julio A. Camarero
Summary: The CXCR4 chemokine is a crucial regulator of leukocyte functions, embryonic development, and cancer progression. CXCR4 antagonists show promise as therapeutic agents for cancer and HIV. This study shows that lipidation can improve the half-life of a bioactive cyclotide antagonist, but the choice of lipid may affect its biological activity.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
Young Hun Chung, Oscar A. Ortega-Rivera, Britney A. Volckaert, Eunkyeong Jung, Zhongchao Zhao, Nicole F. Steinmetz
Summary: Metastatic cancer, accounting for 90% of cancer-related deaths, remains a major challenge in cancer treatment. S100A9, a regulator of inflammation, plays a central role in cancer progression and metastasis, particularly in the lungs. This study developed a plant virus-derived S100A9 vaccine, which effectively prevented tumor seeding and metastatic growth in the lungs by enhancing immunostimulatory cytokines and reducing immunosuppressive factors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Jieru Yang, Farrhana Firdaus, Armira Azuar, Zeinab G. Khalil, Nirmal Marasini, Robert J. Capon, Waleed M. Hussein, Istvan Toth, Mariusz Skwarczynski
Summary: Utilizing cell-penetrating peptides for delivering lipopeptide-based vaccines combined with multilamellar liposomes can efficiently trigger immune responses and generate high antibody titers with high opsonic activity against pathogenic GAS strains. This approach shows promising potential for liposome-based GAS vaccine development.
Article
Biochemistry & Molecular Biology
Xueqin Huang, Lingzhi Chen, Yuping Zhang, Suyan Zhou, Huai-Hong Cai, Ting Li, Hua Jin, Jiye Cai, Haibo Zhou, Jiang Pi
Summary: A novel drug-delivery system targeting cancer cells was developed in this study, allowing the controlled release of anticancer drugs by near-infrared light triggering, leading to synergistic photothermal therapy. This system could induce stronger apoptotic signaling events through reactive oxygen species generation and cytoskeleton disruption.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Zachary D. Crees, Michael P. Rettig, Reyka G. Jayasinghe, Keith Stockerl-Goldstein, Sarah M. Larson, Illes Arpad, Giulio A. Milone, Massimo Martino, Patrick Stiff, Douglas Sborov, Denise Pereira, Ivana Micallef, Gemma Moreno-Jimenez, Gabor Mikala, Maria Liz Paciello Coronel, Udo Holtick, John Hiemenz, Muzaffar H. Qazilbash, Nancy Hardy, Tahir Latif, Irene Garcia-Cadenas, Abi Vainstein-Haras, Ella Sorani, Irit Gliko-Kabir, Inbal Goldstein, Debby Ickowicz, Liron Shemesh-Darvish, Shaul Kadosh, Feng Gao, Mark A. Schroeder, Ravi Vij, John F. DiPersio
Summary: Autologous hematopoietic stem cell transplantation (ASCT) improves survival in multiple myeloma (MM). Motixafortide combined with G-CSF significantly improves the collection of CD34(+) hematopoietic stem cells compared to G-CSF alone. Motixafortide + G-CSF demonstrates superior efficacy in ASCT.
Article
Pharmacology & Pharmacy
Wenting Zhu, Hang Yu, Menglei Jia, Caiyan Lin, Zhongwen Yuan, Xiaoxiao Tan, Pengke Yan
Summary: Pancreatic cancer treatment is hindered by drug resistance and liver metastasis. A new strategy, combination therapy, was developed to address these challenges. By using ATF peptide-decorated liposomal co-loaded with cisplatin and rapamycin, the delivery of drugs to tumor cells was significantly improved, leading to enhanced therapeutic effects in vitro and in vivo. This multi-targeting nanomedicine may provide a new approach for treating metastatic pancreatic cancer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Editorial Material
Oncology
Alessandro Ottaiano, Massimiliano Berretta, Claudia Von Arx, Monica Capozzi, Michele Caraglia
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amalia Luce, Angela Lombardi, Carmela Ferri, Silvia Zappavigna, Madhura S. Tathode, Amanda K. Miles, David J. Boocock, Jayakumar Vadakekolathu, Marco Bocchetti, Roberto Alfano, Rossella Sperlongano, Angela Ragone, Luigi Sapio, Vincenzo Desiderio, Silvio Naviglio, Tarik Regad, Michele Caraglia
Summary: Recently, we have shown that miR-423-5p influences the growth and metastasis of prostate cancer cells. In this study, we investigated the effects of miR-423-5p on the proteomic profile to identify its targets and affected pathways. Proteomic analysis revealed differential expression of 63 proteins in miR-423-5p-transfected cells, and pathway enrichment analysis showed inhibition of glycolysis and amino acid metabolism, along with downregulation of proteins involved in transcription, hypoxia, immune response, inflammation, and ion transport. We also identified seven proteins commonly targeted by miR-423-5p and differentially expressed proteins, and analyzed their expression and impact on patient survival. Overall, miR-423-5p induces alterations in metabolism and tumor-associated processes in prostate cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Francesco Perri, Marco Cascella, Francesco Sabbatino, Maurizio Capuozzo, Vincenza Granata, Silvia Zappavigna, Angela Lombardi, Marianna Scrima, Nadia Petrillo, Monica Ianniello, Marika Casillo, Oreste Gualillo, Guglielmo Nasti, Michele Caraglia, Giovanni Savarese
Summary: This study examines the impact of hypertension, type 2 diabetes, weight, and p53 mutations on the prognosis of metastatic colorectal cancer patients. Patients were diagnosed with type 2 diabetes according to ADA criteria and classified hypertension based on ACC/AHA guidelines. Overall survival analysis showed that diabetic patients had lower disease control rates and that the concurrent presence of type 2 diabetes, BMI, and hypertension was an independent prognostic factor. P53 mutations were found to be associated with BMI and had a negative impact on prognosis, suggesting a complex relationship between metabolism and cancer occurrence.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Sara Martino, Chiara Tammaro, Gabriella Misso, Michela Falco, Marianna Scrima, Marco Bocchetti, Ilaria Rea, Luca De Stefano, Michele Caraglia
Summary: MicroRNA (miRNA) are small nucleotides that regulate physiological functions and diseases, especially in cancer. Detection methods such as RT-qPCR, microarrays, and small RNA sequencing have been used for the past 30 years. The advent of nanotechnology has allowed the development of nanostructured biosensors, which offer advantages such as portability, large surface-volume ratio, and increased sensitivity. This review explores the role of nanostructured biosensors in miRNA detection, particularly using electrochemical and optical sensing methods, and highlights the properties and applications of different nanomaterials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Rossella Di Paola, Ananya De, Raafiah Izhar, Marianna Abate, Silvia Zappavigna, Anna Capasso, Alessandra F. Perna, Antonella La Russa, Giovambattista Capasso, Michele Caraglia, Mariadelina Simeoni
Summary: Chronic kidney disease (CKD) leads to the accumulation and production of uremic toxins, which activate harmful processes. Gut dysbiosis is common in CKD patients and promotes the growth of certain bacteria that release substances like p-Cresol, Indoxyl Sulfate, and p-Cresyl Sulfate. These substances play a role in chronic inflammation, free radical production, and immune dysfunction, potentially contributing to colon cancer development. Further research is needed to fully understand the mechanisms behind this association.
Review
Medicine, Research & Experimental
Elisa Martino, Nunzia D'Onofrio, Camilla Anastasio, Marianna Abate, Silvia Zappavigna, Michele Caraglia, Maria Luisa Balestrieri
Summary: Micro-RNAs (miRNAs) play dual roles as oncogenes and tumor suppressors in carcinogenesis by controlling gene expression at the posttranscriptional level. The off-target effect of miRNAs limits their potential therapeutic use, but encapsulating them in nanostructured carriers enables targeted destruction of cancer cells without harming healthy tissues. Nanoparticles (NPs) with their small size and optimal surface/size ratio can encapsulate, protect, and release miRNAs, providing a promising strategy for cancer treatment. This review discusses the latest advances in miRNA-encapsulating NPs for cancer therapy, with a focus on colorectal cancer and its metastatic forms, which are among the most common malignancies worldwide.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Medicine, Research & Experimental
Marianna Abate, Angela Lombardi, Amalia Luce, Manuela Porru, Carlo Leonetti, Marco Bocchetti, Virginia Campani, Giuseppe De Rosa, Sossio Fabio Graziano, Valeria Nele, Francesco Cardile, Federica Zito Marino, Renato Franco, Andrea Ronchi, Marianna Scrima, Rossella Sperlongano, Roberto Alfano, Gabriella Misso, Evzen Amler, Michele Caraglia, Silvia Zappavigna
Summary: This study demonstrates that nanodiamonds can effectively deliver miRNA to inhibit tumor development and progression. The nanodiamonds have excellent biocompatibility, and the miR-34a conjugated with nanodiamonds can effectively inhibit cancer cell proliferation and migration. Furthermore, the miR-34a-conjugated nanodiamonds exhibit remarkable anti-tumor effects in mouse models.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Oncology
Francesco Perri, Francesco Sabbatino, Alessandro Ottaiano, Roberta Fusco, Michele Caraglia, Marco Cascella, Francesco Longo, Rosalia Anna Rega, Giovanni Salzano, Monica Pontone, Maria Luisa Marciano, Arianna Piccirillo, Massimo Montano, Morena Fasano, Fortunato Ciardiello, Giuseppina Della Vittoria Scarpati, Franco Ionna
Summary: Epstein Barr virus (EBV) is implicated in the development of both solid and hematologic malignancies, particularly nasopharyngeal carcinomas (NPCs). Viral proteins produced during the latent phase of EBV in epithelial cells can induce or promote carcinogenesis and can be targeted by immunotherapy strategies. The use of check-point inhibitors has shown promising results in treating EBV-associated carcinomas.
Review
Oncology
Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Anna Maria Trotta, Francesco Izzo, Francesco Perri, Marco Cascella, Francesco Sabbatino, Vincenza Granata, Marco Correra, Luca Tarotto, Salvatore Stilo, Francesco Fiore, Nicola Martucci, Antonello La Rocca, Carmine Picone, Paolo Muto, Valentina Borzillo, Andrea Belli, Renato Patrone, Edoardo Mercadante, Fabiana Tatangelo, Gerardo Ferrara, Annabella Di Mauro, Giosue Scognamiglio, Massimiliano Berretta, Maurizio Capuozzo, Angela Lombardi, Jerome Galon, Oreste Gualillo, Ugo Pace, Paolo Delrio, Giovanni Savarese, Stefania Scala, Guglielmo Nasti, Michele Caraglia
Summary: Oligometastatic disease is a condition in which cancer spreads to only a few distant sites, and it is associated with a more favorable prognosis compared to polymetastatic disease. Recent studies have identified specific molecular and genetic features that underlie the oligometastatic phenotype, suggesting the potential for personalized therapies. This scoping review highlights new clinical, biological, and methodological challenges in understanding and treating oligometastatic disease.
Article
Immunology
Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti, Maurizio Federico
Summary: The study demonstrates that administration of N-engineered extracellular vesicles can induce immunity in the lungs and control viral replication, suggesting its potential as an effective vaccine strategy.
Article
Biochemistry & Molecular Biology
Rossella Di Raimo, Davide Mizzoni, Massimo Spada, Vincenza Dolo, Stefano Fais, Mariantonia Logozzi
Summary: Plant-derived exosomes (PDEs) are a natural source of antioxidants, and their content varies depending on the fruit or vegetable source. Organic agriculture produces safer and more bioactive-rich PDEs. This study demonstrated that orally administered PDE mixes can restore physiological conditions in mice treated with hydrogen peroxide, with significant antioxidant effects and recovery of the homeostatic condition at the organ level.
Editorial Material
Oncology
Alessandro Ottaiano, Luisa Circelli, Mariachiara Santorsola, Michele Caraglia
Review
Biology
Alessandro Ottaiano, Monica Ianniello, Mariachiara Santorsola, Raffaella Ruggiero, Roberto Sirica, Francesco Sabbatino, Francesco Perri, Marco Cascella, Massimiliano Di Marzo, Massimiliano Berretta, Michele Caraglia, Guglielmo Nasti, Giovanni Savarese
Summary: Cancer is a complex disease characterized by aberrant cellular behaviors and genetic variances, leading to tumor heterogeneity. This heterogeneity poses challenges in cancer prognosis and treatment, and understanding and quantifying it is crucial. This review emphasizes the significance of comprehending tumor heterogeneity to raise awareness about this elusive characteristic of cancer.
Review
Radiology, Nuclear Medicine & Medical Imaging
Valerio Nardone, Caterina Romeo, Emma D'Ippolito, Pierpaolo Pastina, Maria D'Apolito, Luigi Pirtoli, Michele Caraglia, Luciano Mutti, Giovanna Bianco, Antonella Consuelo Falzea, Rocco Giannicola, Antonio Giordano, Pierosandro Tagliaferri, Claudia Vinciguerra, Isacco Desideri, Mauro Loi, Alfonso Reginelli, Salvatore Cappabianca, Pierfrancesco Tassone, Pierpaolo Correale
Summary: Non-small cell lung cancer (NSCLC) patients often experience complications from central nervous system (CNS) metastases, which greatly impact their life expectancy and quality of life. Current clinical trials involving neurosurgery, radiotherapy (RT), and systemic treatments have yielded conflicting results. CNS involvement is more frequent in NSCLC patients with EGFR activating mutations or ALK rearrangement, suggesting the potential role of targeted therapy as the initial treatment instead of local therapies such as RT or surgery. However, the use of accurate brain imaging, such as MRI, to identify patients who could benefit from local therapies has not been extensively studied in clinical research. Additionally, there are no clear guidelines on the timing of intervention with regards to innovative precision medicine approaches when concomitant RT is required. This review aims to discuss therapeutic strategies that integrate medical and radiation oncology in patients with metastatic NSCLC (mNSCLC) adenocarcinoma with CNS involvement and specific genetic mutations.
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.