Article
Medicine, Research & Experimental
Marius E. Mayerhoefer, Markus Raderer, Wolfgang Lamm, Verena Pichler, Sarah Pfaff, Michael Weber, Barbara Kiesewetter, Markus Hacker, Lukas Kazianka, Philipp B. Staber, Hans-Juergen Wester, Johannes Rohrbeck, Ingrid Simonitsch-Klupp, Alexander Haug
Summary: In this prospective study, [Ga-68]Pentixafor-PET showed higher sensitivity and detection rates compared to [F-18]FDG-PET in patients with mantle cell lymphoma (MCL), indicating that it may be a potential alternative for imaging in these patients. The study also found that SUVs and TBRs were significantly higher for [Ga-68]Pentixafor-PET, with the most notable difference observed in mean TBRblood values.
Editorial Material
Hematology
Anne-Segolene Cottereau
Summary: In this study, a novel PET radio tracer was used to assess residual disease in MALT lymphoma after first-line Helicobacter pylori eradication.
Article
Chemistry, Multidisciplinary
Chi-Hyeon Yoo, Jonathan M. DuBois, Lu Wang, Yongjin Tang, Lu Hou, Hao Xu, Jiahui Chen, Steven H. Liang, David Izquierdo-Garcia, Hsiao-Ying Wey
Summary: This study aimed to develop a template-based attenuation correction (AC) for the nonhuman primate (NHP) brain and evaluate its effects on PET data quantification. The results showed that the segmentation-based AC had lower SUV and VT of [F-18]PF-06455943, while the template-based method had higher estimated occupancy in the bolus-infusion study. However, further studies may be needed to validate against AC methods based on computed tomography (CT).
Article
Radiology, Nuclear Medicine & Medical Imaging
Yinjie Gao, Jie Ding, Yunying Cui, Tianyi Li, Hao Sun, Dachun Zhao, Yushi Zhang, Li Huo, Anli Tong
Summary: Ga-68-pentixafor PET/CT shows high sensitivity and specificity in the diagnosis of functional nodules in primary aldosteronism. It performs better in detecting nodules with a diameter greater than 1 cm.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Johannes Streffer, Valerie Treyer, Alfred Buck, Simon M. Ametamey, Milen Blagoev, Ralph P. Maguire, Aurelie Gautier, Yves P. Auberson, Mark E. Schmidt, Ivan-Toma Vranesic, Baltazar Gomez-Mancilla, Fabrizio Gasparini
Summary: This study investigates the occupancy of mGluR5 receptors by Mavoglurant in the human brain, demonstrating dose-dependent displacement of [C-11]-ABP688, a radioligand, with different doses of Mavoglurant. The findings provide guidance for dosing of Mavoglurant in current and future clinical studies, while confirming the utility of [C-11]-ABP688 as a tool to study drug-induced occupancy of mGlu5 receptors in living human brain.
Article
Neurosciences
Mia I. Allen, Angela N. Duke, Susan H. Nader, Adrienne Adler-Neal, Kiran Solingapuram K. Sai, Beth A. Reboussin, H. Donald Gage, Ronald J. Voll, Akiva Mintz, Mark M. Goodman, Michael A. Nader
Summary: Brain imaging studies using PET have shown that long-term cocaine use is associated with lower levels of dopamine D2/D3 receptors and inconsistent effects on dopamine transporter availability. This study used PET imaging to examine the effects of cocaine self-administration on D2/D3 receptor availability and dopamine transporter availability in female monkeys. The results demonstrated sex differences in the relationship between D2/D3 receptor availability and vulnerability to long-term cocaine use, with baseline D2/D3 receptor availability only correlated with cocaine self-administration in the first week of exposure.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasuyuki Kimura, Keisuke Takahata, Toshiharu Shimazaki, Soichiro Kitamura, Chie Seki, Yoko Ikoma, Masanori Ichise, Kazunori Kawamura, Makiko Yamada, Ming-Rong Zhang, Makoto Higuchi, Izumi Nishino, Tetsuya Suhara
Summary: This study aimed to evaluate the pharmacokinetics and pharmacodynamics of enerisant, a novel antagonist and inverse agonist for histamine H-3 receptors. The results showed dose-dependent receptor occupancy of enerisant in the brain and its variation over time.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Isaline Renard, Juozas Domarkas, Sophie Poty, Benjamin P. Burke, David P. Roberts, Christine Goze, Franck Denat, Christopher J. Cawthorne, Stephen J. Archibald
Summary: The CXCR4 chemokine receptor is over-expressed in many cancers, indicating aggressive behavior and poor prognosis. Targeting and imaging CXCR4 expression in tumors can guide treatment selection and patient stratification. Radiolabeled conjugates of AMD3100, a CXCR4-specific agent, were evaluated in mice and compared to the known PET imaging agent [68Ga]Pentixafor. One radiotracer showed higher accumulation in the tumor, indicating potential for CXCR4-targeted imaging in cancer patients.
NUCLEAR MEDICINE AND BIOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Wenxiang Ding, Qiaoqiao Ding, Kewei Chen, Miao Zhang, Li Lv, David Dagan Feng, Lei Bi, Jinman Kim, Qiu Huang
Summary: Dynamic PET imaging provides more comprehensive physiological information than conventional static PET imaging. The proposed modified Logan reference plot model and self-supervised convolutional neural network improve noise performance and accurately estimate the distribution volume ratio in dynamic PET with a shortened scanning protocol. The method has the potential to add clinical value by providing both DVR and SUV simultaneously.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas K. Buck, Alexander Haug, Niklas Dreher, Alessandro Lambertini, Takahiro Higuchi, Constantin Lapa, Alexander Weich, Martin G. Pomper, Hans-Juergen Wester, Anja Zehndner, Andreas Schirbel, Samuel Samnick, Marcus Hacker, Verena Pichler, Stefanie Hahner, Martin Fassnacht, Hermann Einsele, Sebastian E. Serfling, Rudolf A. Werner
Summary: In recent years, molecular imaging targeting CXCR4 has been increasingly used in various clinical settings. This study aimed to assess radiopharmaceutical uptake and image contrast to determine the clinical applications for CXCR4-directed imaging and investigate the impact of specific activity on scan contrast.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Daniel Kwon, Zhengxing Zhang, Jutta Zeisler, Hsiou-Ting Kuo, Kuo-Shyan Lin, Francois Benard
Summary: The study developed a radiotracer [Ga-68]Ga-BL31 targeting CXCR4, which showed lower kidney retention and excellent imaging contrast, making it suitable for PET imaging and radioligand therapy.
Review
Biochemistry & Molecular Biology
Ana Sofia Valles, Francisco J. Barrantes
Summary: Cell membrane compartmentalization is crucial for cells to carry out specific tasks and biochemical functions spatially. This lateral heterogeneity ranges from nanoscopic to micrometric domains, serving a variety of demands in cell physiology. Dendritic spines, subcellular structures in neurons, exploit compartmentalization to house neurotransmitter receptors and enzymes in a small volume.
Article
Medicine, Research & Experimental
Daniel Kwon, Jerome Lozada, Zhengxing Zhang, Jutta Zeisler, Richel Poon, Chengcheng Zhang, Aron Roxin, Kuo-Shyan Lin, David Perrin, Francois Benard
Summary: C-X-C chemokine receptor 4 (CXCR4) is highly expressed in cancer and plays a role in metastasis and poor prognosis. Two new radiotracers, BL08 and BL09, demonstrate high tumor uptake and visualization, showing potential for CXCR4-targeted PET imaging with improved contrast ratios compared to existing radioligands.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biology
Xia Lu, Raffaella Calabretta, Wolfgang Wadsak, Alexander R. Haug, Marius Mayerhoefer, Markus Raderer, Xiaoli Zhang, Jingle Li, Marcus Hacker, Xiang Li
Summary: This study compared the uptake of [Ga-68]PentixaFor and [F-18]FDG in arterial lesions and found that [Ga-68]PentixaFor PET/MRI identified more lesions and showed higher uptake. It also revealed an increased uptake of [Ga-68]PentixaFor in patients with high-risk cardiovascular factors and a correlation between elevated uptake in active arterial segments and the heart.
Article
Medicine, Research & Experimental
Sabrina Kraus, Philipp Klassen, Malte Kircher, Alexander Dierks, Stefan Habringer, Alexander Gaeble, Klaus Martin Kortuem, Niels Weinhold, Valeeza Ademaj-Kospiri, Rudolf A. Werner, Andreas Schirbel, Andreas K. Buck, Peter Herhaus, Hans-Juergen Wester, Andreas Rosenwald, Wolfgang A. Weber, Hermann Einsele, Ulrich Keller, Leo Rasche, Constantin Lapa
Summary: This study evaluates the prognostic impact of splenic CXCR4 expression in patients with multiple myeloma (MM). The findings suggest that splenic Ga-68-Pentixafor uptake is associated with disease progression, treatment history, and clinical outcome. Reduced splenic uptake is linked to unfavorable prognosis and can serve as an independent predictor of survival.
Article
Oncology
Jasper J. L. van Geel, Jorianne Boers, Sjoerd G. Elias, Andor W. J. M. Glaudemans, Erik F. J. de Vries, Geke A. P. Hospers, Michel van Kruchten, Evelien J. M. Kuip, Agnes Jager, Willemien C. Menke-van der Houven Van Oordt, Bert van der Vegt, Elisabeth G. E. de Vries, Carolina P. Schroder
Summary: The clinical validity of [F-18]FES-PET in determining tumor ER status in MBC patients has been established in this study. Qualitative assessment of whole-body [F-18]FES-PET shows high diagnostic accuracy in predicting ER expression in biopsied metastasis. Quantitative [F-18]FES uptake in the corresponding metastasis also has predictive value for ER immunohistochemistry. Meta-analysis suggests improved diagnostic performance with the addition of this study's data.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cyprien G. J. Guerrin, Alexandre Shoji, Janine Doorduin, Erik F. J. de Vries
Summary: Prenatal infection may lead to neurodevelopmental changes and increased brain glucose consumption, but not microglia activation, in the offspring. Additionally, prenatal infection may result in increased anxiety-like behavior during adolescence and recognition memory deficits in adulthood.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chris W. J. van der Weijden, Milena S. Pitombeira, Yudith R. A. Haveman, Carlos A. Sanchez-Catasus, Kenia R. Campanholo, Guilherme D. Kolinger, Carolina M. Rimkus, Carlos A. Buchpiguel, Rudi A. J. O. Dierckx, Remco J. Renken, Jan F. Meilof, Erik F. J. de Vries, Daniele de Paula Faria
Summary: Graph theoretical network analysis can be used to assess subtle changes in brain networks in multiple sclerosis (MS) patients. This study found that lesion filling can increase the detection rate of network alterations in MS, but it also introduces significant artifacts, suggesting that caution should be applied.
INSIGHTS INTO IMAGING
(2022)
Article
Medicine, Research & Experimental
Kavya Prasad, Erik F. J. de Vries, Jurgen W. A. Sijbesma, Lara Garcia-Varela, Daniel A. Vazquez-Matias, Rodrigo Moraga-Amaro, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Aren van Waarde
Summary: This study investigates the regulation of A(2A) receptors on D-2 receptor binding using positron emission tomography (PET) technique. It shows that the A(2A) agonist CGS21680 can reduce the availability of D2 receptors in the striatum.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Nafiseh Ghazanfari, Aren van Waarde, Janine Doorduin, Jurgen W. A. Sijbesma, Maria Kominia, Martin Koelewijn, Khaled Attia, David Vallez-Garcia, Antoon T. M. Willemsen, Andre Heeres, Rudi A. J. O. Dierckx, Ton J. Visser, Erik F. J. de Vries, Philip H. Elsinga
Summary: The study demonstrates the interaction of AG-0029 with dopamine D-2/D-3 receptors and histamine H-3 receptors in the rat brain using positron emission tomography (PET). These findings suggest that AG-0029 may be beneficial for ameliorating both motor and cognitive symptoms of Parkinson's disease.
MOLECULAR PHARMACEUTICS
(2022)
Review
Clinical Neurology
Chris W. J. van der Weijden, Emma Biondetti, Ingomar W. Gutmann, Hildebrand Dijkstra, Rory McKerchar, Daniele de Paula Faria, Erik F. J. de Vries, Jan F. Meilof, Rudi A. J. O. Dierckx, Valentin H. Prevost, Alexander Rauscher
Summary: Myelin is a protective sheath made of phospholipid bilayer and water that wraps around axons. Non-invasive quantitative myelin imaging methods are needed for evaluating myelin damage, assessing the efficacy of remyelination therapies, and monitoring brain maturation in children. Different MRI and PET techniques have been developed for myelin imaging based on various biophysical principles. This review provides an overview of these techniques, including image acquisition, data analysis, and validation status, and concludes that quantitative susceptibility mapping, inhomogeneous magnetization transfer for MRI, and C-11-MeDAS for PET are the most promising techniques.
Review
Radiology, Nuclear Medicine & Medical Imaging
Daniel Aaron Vazquez-Matias, Erik F. J. de Vries, Rudi A. J. O. Dierckx, Janine Doorduin
Summary: Major depressive disorder is a growing and poorly understood pathology that requires research in animal paradigms due to technical and ethical limitations. PET imaging has been used in preclinical studies to investigate glucose metabolism, neuroreceptor populations, and the inflammatory response associated with depressive phenotypes. This review summarizes the findings in animal models and discusses the relevance of PET imaging for understanding depression and developing new therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Chris W. J. van der Weijden, Pascalle Mossel, Anna L. Bartels, Rudi A. J. O. Dierckx, Gert Luurtsema, Adriaan A. Lammertsma, Antoon T. M. Willemsen, Erik F. J. de Vries
Summary: Pharmacokinetic modelling with arterial sampling is the gold standard for analyzing dynamic PET data of the brain, but it has limited clinical application due to its invasive nature. Non-invasive methods, such as population based input function (PBIF), image derived input function (IDIF), and simultaneous estimation of the input function (SIME), have been proposed as alternatives. This systematic review assesses the correspondence of these non-invasive methods with the gold standard and highlights the need for validation before clinical implementation.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Psychology, Clinical
Iris Jonker, Janine Doorduin, Henderikus Knegtering, Erna Van't Hag, Rudi A. Dierckx, Erik F. J. de Vries, Robert A. Schoevers, Hans C. Klein
Summary: This study aimed to determine whether add-on treatment of schizophrenic patients with the anti-viral drug valaciclovir would reduce hippocampal neuroinflammation and improve cognitive symptoms. Results showed that valaciclovir treatment reduced neuroinflammation in multiple brain regions, but had no effect on psychotic symptoms or cognitive functioning.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Cyprien G. J. Guerrin, Janine Doorduin, Kavya Prasad, Daniel A. Vazquez-Matias, Lara Barazzuol, Erik F. J. de Vries
Summary: Early adverse experiences increase vulnerability to immune challenges later in life, especially when they occur during brain development. This study found that male rats exposed to social defeat during juvenile age showed enhanced anhedonia and social interaction dysfunction after an immune challenge in adulthood, while rats exposed to social defeat during adulthood did not exhibit this enhanced susceptibility. Additionally, exposure to social defeat during juvenile age increased microglia cell density and glial reactivity to the immune challenge more than exposure during adulthood.
NEUROBIOLOGY OF STRESS
(2023)
Article
Behavioral Sciences
Cyprien G. J. Guerrin, Erik F. J. de Vries, Kavya Prasad, Daniel A. Vazquez-Matias, Lesley E. Manusiwa, Lara Barazzuol, Janine Doorduin
Summary: Prenatal immune activation and postnatal immune challenge had a significant impact on behavior in female rats. The combination of maternal immune activation and immune challenge during adolescence resulted in long-lasting changes in social behavior and locomotion. These findings highlight the importance of immune activation and challenge during critical periods of development.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Psychology, Clinical
Anne-Sophie D. Enthoven, Shiral S. Gangadin, Lieuwe de Haan, Wim Veling, Erik F. J. de Vries, Janine Doorduin, Marieke J. H. Begemann, Iris E. C. Sommer
Summary: Childhood trauma may impact the severity of depressive and negative symptoms in patients with schizophrenia spectrum disorders, with differences between sexes. Depressive symptoms in men were associated with total trauma scores and emotional abuse, while in women they were associated with sexual abuse. Negative symptoms in men were linked to total trauma scores and emotional neglect, while in women there was no clear link potentially due to statistical power limitations.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Cyprien G. J. Guerrin, Kavya Prasad, Daniel A. Vazquez-Matias, Jing Zheng, Maria Franquesa-Mullerat, Lara Barazzuol, Janine Doorduin, Erik F. J. de Vries
Summary: Maternal infection during pregnancy and childhood social trauma affect behavior and synaptic density, possibly due to changes in microglial cells and cytokine release.
NEUROBIOLOGY OF STRESS
(2023)
Review
Oncology
Jasper J. L. van Geel, Erik F. J. de Vries, Michel van Kruchten, Geke A. P. Hospers, Andor W. J. M. Glaudemans, Carolina P. Schroder
Summary: Molecular imaging, such as PET, is being used more frequently as a biomarker to predict and assess treatment response in breast cancer. Specific tracers are used to measure metabolic activity, estrogen receptor expression, and human epidermal growth factor receptor 2 expression. These biomarkers have potential in predicting treatment response and outcome, but more studies are needed before implementation in clinical practice.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Toxicology
Didima M. G. de Groot, Louisa Linders, Reinier Kayser, Rianne Nederlof, Celine de Esch, Roderick C. Slieker, C. Frieke Kuper, Andre Wolterbeek, V. Jeroen de Groot, Andor Veltien, Arend Heerschap, Aren van Waarde, Rudi A. J. O. Dierckx, Erik F. J. de Vries
Summary: This study investigated the impact of environmental chemicals on brain development and found that di-n-octyltin dichloride (DOTC) can affect both structural and functional brain development. The study also revealed the involvement of immune system development and functioning in the impairment of the nervous system. These findings support the close connection between the immune and nervous systems in brain development.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
