A compendium of cyclic sugar amino acids and their carbocyclic and heterocyclic nitrogen analogues

Membrane Interactions and Pore Formation by the Antimicrobial Peptide Protegrin

(2013) Themis Lazaridis et al.   BIOPHYSICAL JOURNAL

3-Hydroxyazetidine Carboxylic Acids: Non-Proteinogenic Amino Acids for Medicinal Chemists

(2013) Andreas F. G. Glawar et al.   ChemMedChem

A Nitro Sugar-Mediated Stereocontrolled Synthesis of β2-Amino Acids: Synthesis of a Polyhydroxylated trans-2-Amino­cyclohexanecarboxylic Acid

(2012) José M. Otero et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Ab initioMO Theory - An Important Tool in Foldamer Research: Prediction of Helices in Oligomers ofω-Amino Acids

(2012) Carsten Baldauf et al.   HELVETICA CHIMICA ACTA

Lipodepsipeptide Empedopeptin Inhibits Cell Wall Biosynthesis through Ca2+-dependent Complex Formation with Peptidoglycan Precursors

(2012) Anna Müller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytotoxic Effects of Combination of Oxidosqualene Cyclase Inhibitors with Atorvastatin in Human Cancer Cells

(2012) Davide Staedler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microbial enantioselective removal of the N-benzyloxycarbonyl amino protecting group

(2012) Michèle Maurs et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Evidence for Helical Structure in a Tetramer of α2-8 Sialic Acid: Unveiling a Structural Antigen

(2012) Marcos D. Battistel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly-amido-saccharides: Synthesis via Anionic Polymerization of a β-Lactam Sugar Monomer

(2012) Eric L. Dane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes

(2012) Jine Li et al.   Microbial Cell Factories

Spirocyclic Nucleosides in Medicinal Chemistry: An Overview

(2012) Raquel G. Soengas et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Enantioselective synthesis of gabapentin analogues via organocatalytic asymmetric Michael addition of α-branched aldehydes to β-nitroacrylates

(2012) Masanori Yoshida et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of cyclically constrained sugar derived α/β- and α/γ-peptides

(2012) Antonio Franconetti et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

New Preorganized γ-Amino Acids as Foldamer Building Blocks

(2012) Li Guo et al.   ORGANIC LETTERS

Pipecolic Acid, an Endogenous Mediator of Defense Amplification and Priming, Is a Critical Regulator of Inducible Plant Immunity

(2012) H. Navarova et al.   PLANT CELL

Asymmetric Synthesis of Pipecolic Acid and Derivatives

(2012) Andrew Sutherland et al.   SYNTHESIS-STUTTGART

Exploiting the Addition of Trimethyl(trifluoromethyl)silane to Functionalized N-Benzylimines for the Preparation of Two Novel x-Trifluoromethyl x-Amino Acids

(2012) Pavel Mykhailiuk et al.   SYNTHESIS-STUTTGART

Helical secondary structures in 2:1 and 1:2 α/γ-peptide foldamers

(2012) Li Guo et al.   TETRAHEDRON

Simple conversion of fully protected amino acids to zwitterions

(2012) Junliang Hao et al.   TETRAHEDRON LETTERS

Synthesis of three branched iminosugars [(3R,4R,5S)-3-(hydroxymethyl)piperidine-3,4,5-triol, (3R,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol and (3S,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol] and a branched trihydroxynipecotic acid [(3R,4R,5R)-3,4,5-trihydroxypiperidine-3-carboxylic acid] from sugar lactones with a carbon substituent at C-2

(2012) Michela I. Simone et al.   TETRAHEDRON-ASYMMETRY

(2R,6S)-tert-Butyl 2-(benzhydrylcarbamoyl)-6-methylmorpholine-4-carboxylate

(2011) Haiyang Wang et al.   ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

Synthesis of new functionalized aziridine-2- and azetidine-3-carboxylic acid derivatives of potential interest for biological and foldameric applications

(2011) Asta Žukauskaitė et al.   AMINO ACIDS

C-3 branched δ-3,5-cis- and trans-THF sugar amino acids: synthesis of the first generation of branched homooligomers

(2011) Michela I. Simone et al.   AMINO ACIDS

Foldamers containing γ-amino acid residues or their analogues: structural features and applications

(2011) Francelin Bouillère et al.   AMINO ACIDS

α/β-Peptide foldamers: state of the art

(2011) Ludwig K. A. Pilsl et al.   AMINO ACIDS

Characteristic Structural Parameters for the γ-Peptide 14-Helix: Importance of Subunit Preorganization

(2011) Li Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diversity-Oriented Production of Metabolites Derived from Chorismate and Their Use in Organic Synthesis

(2011) Johannes Bongaerts et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic [3+2] Annulation of Aminocyclopropanes for the Enantiospecific Synthesis of Cyclopentylamines

(2011) Florian de Nanteuil et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tripropeptin C Blocks the Lipid Cycle of Cell Wall Biosynthesis by Complex Formation with Undecaprenyl Pyrophosphate

(2011) Hideki Hashizume et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles

(2011) Peter Wipf et al.   Beilstein Journal of Organic Chemistry

Conformationally restricted analogs of the direct thrombin inhibitor FM 19

(2011) Elizabeth A. Girnys et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3β (GSK-3β) inhibitors for type 2 diabetics

(2011) Shigeki Seto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond

(2011) Venkatareddy Udumula et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases

(2011) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Catalytic Asymmetric Synthesis of Isoxazoline-N-oxides through Conjugate Addition–Cyclization under Phase-Transfer Conditions

(2011) Taichi Kano et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Synthesis of 4-amino-4,5-dideoxy-l-lyxofuranose derivatives and their evaluation as fucosidase inhibitors

(2011) Carine Chevrier et al.   CARBOHYDRATE RESEARCH

“Inosaminoacids”: novel inositol–amino acid hybrid structures accessed by microbial arene oxidation

(2011) Sarah Pilgrim et al.   CHEMICAL COMMUNICATIONS

HYDRAmers: design, synthesis and characterization of different generation novel Hydra-like dendrons based on multifunctionalized adamantane

(2011) Giuseppe Lamanna et al.   CHEMICAL COMMUNICATIONS

A general synthetic approach to the amnesic shellfish toxins: total synthesis of (−)-isodomoic acid B, (−)-isodomoic acid E and (−)-isodomoic acid F

(2011) Gilles Lemière et al.   CHEMICAL COMMUNICATIONS

Peptidic foldamers: ramping up diversity

(2011) Tamás A. Martinek et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and Structural Characterization of Homochiral Homo-oligomers of Parent cis- and trans-Furanoid-β-Amino Acids

(2011) Sunil K. Pandey et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exploring the Conformational and Biological Versatility of β-Turn-Modified Gramicidin S by Using Sugar Amino Acid Homologues that Vary in Ring Size

(2011) Annemiek D. Knijnenburg et al.   CHEMISTRY-A EUROPEAN JOURNAL

Second-generation sulfonamide inhibitors of d-glutamic acid-adding enzyme: Activity optimisation with conformationally rigid analogues of d-glutamic acid

(2011) Izidor Sosič et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of protein–protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors

(2011) Luca Rizzi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Iminosugar Analogues of Phosphatidyl Inositol as Potential Inhibitors of Protein Kinase B (Akt)

(2011) Alexandre Orsato et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Peptide and peptoid foldamers in medicinal chemistry

(2011) W Seth Horne   Expert Opinion on Drug Discovery

Mannuronic Acids: Reactivity and Selectivity

(2011) Jeroen D. C. Codée et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Libraries on Oxetane δ-Amino Acid Scaffolds: Syntheses and Evaluation of Physicochemical and Metabolic Properties

(2011) Susana Dias Lucas et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

TiCl4-Promoted Cyclization Reactions of Aminoacetals and Ethenetricarboxylates Leading to Nitrogen-Containing Heterocycles

(2011) Shoko Yamazaki et al.   JOURNAL OF ORGANIC CHEMISTRY

Silver-Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-Boryl Acrylates

(2011) Ana López-Pérez et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Structural Studies of Homooligomers of Geminally Disubstituted β2,2-Amino Acids with Carbohydrate Side Chain

(2011) Gangavaram V. M. Sharma et al.   JOURNAL OF ORGANIC CHEMISTRY

Diaxial Diureido Decalins as Compact, Efficient, and Tunable Anion Transporters

(2011) Sabir Hussain et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective preparation of β,γ-methano-GABA derivatives

(2011) David J. Aitken et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Amphiphilic allylation of arylidene-1,3-oxazol-5(4H)-one using bis-π-allylpalladium complexes: an approach to synthesis of cyclohexyl and cyclohexenyl α-amino acids

(2011) Afaf R. Genady et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design and synthesis of trans-3-aminopyran-2-carboxylic acid (APyC) and α/β-peptides with 9/11-helix

(2011) Gangavaram V. M. Sharma et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Three-Component Coupling Approach to Trachyspic Acid

(2011) Daniel C. Schmitt et al.   ORGANIC LETTERS

Simultaneous Parallel and Antiparallel Self-Assembly in a Triazole/Amide Macrocycle Conformationally Homologous tod-,l-α-Amino Acid Based Cyclic Peptides: NMR and Molecular Modeling Study

(2011) Abhijit Ghorai et al.   ORGANIC LETTERS

Diastereoselective Control of Intramolecular Aza-Michael Reactions Using Achiral Catalysts

(2011) Cheng Zhong et al.   ORGANIC LETTERS

Iron-Catalyzed [3 + 2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

(2011) Fides Benfatti et al.   ORGANIC LETTERS

In SituGeneration of the Coates Catalyst: A Practical and Versatile Catalytic System for the Carbonylation ofmeso-Epoxides

(2011) Prasad Ganji et al.   ORGANIC LETTERS

Large-Scale Asymmetric Synthesis of the Bioprotective Agent JP4-039 and Analogs

(2011) Marie-Céline Frantz et al.   ORGANIC LETTERS

Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

(2011) Johannes A. Burkhard et al.   ORGANIC LETTERS

Creation and manipulation of common functional groups en route to a skeletally diverse chemical library

(2011) J. Cui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of (±)-8-Oxa-3-azabicyclo[3.2.1]octan-2-thione and (±)-2-Oxa-5-azabicyclo[2.2.1]heptan-6-thione: Potential Synthons for the Preparation of Novel Heteroaryl-Annulated Bicyclic Morpholines

(2011) Daniel Walker et al.   SYNTHESIS-STUTTGART

Expedient Synthesis ofcis- andtrans-3-Aminocyclobutanecarboxylic Acids

(2011) Dmytro S. Radchenko et al.   SYNTHETIC COMMUNICATIONS

Synthesis and Characterization of Novel Bi- and Tricyclic α-Amino Acids

(2011) Matthew R. Johnson et al.   SYNTHETIC COMMUNICATIONS

4-(1-Haloalkyl)-3-nitrotetrahydrofurans as versatile scaffolds for the synthesis of diversely functionalized tetrahydrofurans

(2011) Ullrich Jahn et al.   TETRAHEDRON

Sulfanyl-methylene-5(4H)-oxazolones and β-sulfanyl-α-nitroacrylates as appealing dienophiles for the synthesis of conformationally constrained cysteine analogues

(2011) Alessandro Ruffoni et al.   TETRAHEDRON

Rapid access to cis-cyclobutane γ-amino acids in enantiomerically pure form

(2011) Virginie André et al.   TETRAHEDRON LETTERS

A short stereoselective synthesis of the protected uracil 3′-epi-polyoxin C

(2011) Jozef Gonda et al.   TETRAHEDRON-ASYMMETRY

Stereodivergent approach to both syn- and anti-isomers of γ-amino-β-hydroxy acids: (3S,4S)- and (3R,4S)-AHPPA derivatives

(2011) Dongwon Yoo et al.   TETRAHEDRON-ASYMMETRY

Pentafluorophenyl (3R,4R,5S)-5-{[(3R,4R,5S)-5-azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxamido]methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate

(2010) Michela I. Simone et al.   ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

(3R,4R,5R)-5-(Acetamidomethyl)-N-benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide

(2010) Michela I. Simone et al.   ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

Asymmetric Synthesis of 2,3,4-Trisubstituted Functionalised Tetrahydrofurans via an Organocatalytic Michael Addition as Key Step

(2010) Dieter Enders et al.   ADVANCED SYNTHESIS & CATALYSIS

An efficient route towards a new branched tetrahydrofurane δ-sugar amino acid from a pyrolysis product of cellulose

(2010) Andrea Defant et al.   AMINO ACIDS

Proof of the Existence of an Unstable Amino Acid: Pleurocybellaziridine in Pleurocybella porrigens

(2010) Toshiyuki Wakimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Three-Component Coupling Reactions of Silyl Glyoxylates, Vinyl Grignard Reagent, and Nitroalkenes: An Efficient, Highly Diastereoselective Approach to Nitrocyclopentanols

(2010) Gregory R. Boyce et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Damage of the Bacterial Cell Envelope by Antimicrobial Peptides Gramicidin S and PGLa as Revealed by Transmission and Scanning Electron Microscopy

(2010) M. Hartmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

(2010) José L Jiménez Blanco et al.   Beilstein Journal of Organic Chemistry

Membrane lysis by gramicidin S visualized in red blood cells and giant vesicles

(2010) S. Semrau et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Design, synthesis, biological evaluation, and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein

(2010) Oliver Schwardt et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of conformationally constrained glycerol 3-phosphate acyltransferase inhibitors

(2010) Edward A. Wydysh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups

(2010) Srikanth Venkatraman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and structure–activity relationship studies of N-arylsulfonyl morpholines as γ-secretase inhibitors

(2010) Hongmei Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A new insight on the hypochlorous acid scavenging mechanism of tryptamine and tryptophan derivatives

(2010) Luísa C. Carvalho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Remarkable Stability of Chimeric, Sialic Acid-derived α/δ-Peptides in Human Blood Plasma

(2010) Jonel P. Saludes et al.   Chemical Biology & Drug Design

Novel helical foldamers: organized heterogeneous backbone folding in 1 : 1 α/nucleoside-derived-β-amino acid sequences

(2010) Srivari Chandrasekhar et al.   CHEMICAL COMMUNICATIONS

High-Yielding Synthesis of the Anti-Influenza Neuraminidase Inhibitor (−)-Oseltamivir by Two “One-Pot” Sequences

(2010) Hayato Ishikawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exploitation of Furanoid 5-Azido-3-C-Branched-Chain Sugars Towards Highly Functionalized Nitrogen-Containing Carbohydrate Derivatives

(2010) Nuno M. Xavier et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Cascade Annulation Based Convergent Approach to Racemic Tetrodotoxin

(2010) Fernando Cagide-Fagín et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Oxetanes in Drug Discovery: Structural and Synthetic Insights

(2010) Georg Wuitschik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Selective Norbornane-Type Aspartate Analogue Inhibitors of the Glutamate Transporter 1 (GLT-1) from the Chemical Universe Generated Database (GDB)

(2010) Erika Luethi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pipecolic Acid Derivatives As Small-Molecule Inhibitors of theLegionellaMIP Protein

(2010) Christina Juli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unexpected Cleavage of 2-Azido-2-(hydroxymethyl)oxetanes: Conformation Determines Reaction Pathway?

(2010) Elisa Farber et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and In Vitro Evaluation of Gabapentin Prodrugs that Target the Human Apical Sodium-Dependent Bile Acid Transporter (hASBT)

(2010) Rana Rais et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Tandem 6π-Electrocyclization and Cycloaddition of Nitrodienes to Yield Multicyclic Nitroso Acetals

(2010) Gardner S. Creech et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and biological activities of Schiff bases of gabapentin with different aldehydes and ketones: a structure–activity relationship study

(2010) Lingappa Mallesha et al.   MEDICINAL CHEMISTRY RESEARCH

Concise syntheses of selective inhibitors against α-1,3-galactosyltransferase

(2010) Guo-Liang Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 5-Azaindoles via a Cycloaddition Reaction between Nitriles and Donor−Acceptor Cyclopropanes

(2010) Mahmoud M. Abd Rabo Moustafa et al.   ORGANIC LETTERS

Diastereoselective Intramolecular Additions of Allyl- and Propargylsilanes to Iminium Ions: Synthesis of Cyclic and Bicyclic Quaternary Amino Acids

(2010) Santos Fustero et al.   ORGANIC LETTERS

Synthesis and Structural Analysis of a New Class of Azaspiro[3.3]heptanes as Building Blocks for Medicinal Chemistry

(2010) Johannes A. Burkhard et al.   ORGANIC LETTERS

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 Å resolution and 100 K: The role of the water structure and its contribution to binding

(2010) Mary Gregoriou et al.   PROTEIN SCIENCE

A Straightforward Route to Novel α,α-Disubstituted Tetrahydrofuran β-Amino Acids and Spirodiketopiperazines from Sugar Lactones

(2010) Raquel Soengas   SYNLETT

Spiranic d-gluco-configured N-substituted thiohydantoins as potential enzymatic inhibitors

(2010) Consolación Gasch et al.   TETRAHEDRON

Monomers for preparation of amide linked RNA: synthesis of C3′-homologated nucleoside amino acids from d-xylose

(2010) Paul Tanui et al.   TETRAHEDRON

Flexible palladium-catalysed amidation reactions for the synthesis of complex aryl amides

(2010) Christopher Barfoot et al.   TETRAHEDRON LETTERS

The design of efficient and selective routes to a key 1,4-cis-substituted cyclohexylamide intermediate

(2010) Christopher Barfoot et al.   TETRAHEDRON LETTERS

Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases

(2010) Daniel Best et al.   TETRAHEDRON-ASYMMETRY

Esterase-mediated synthesis of optically active GABA analogues containing a stereogenic all-carbon quaternary carbon atom

(2010) Fulvia Felluga et al.   TETRAHEDRON-ASYMMETRY

The formal synthesis of 3-epi jaspine B using stereoselective intramolecular oxa-Michael addition

(2010) G. Srinivas Rao et al.   TETRAHEDRON-ASYMMETRY

Studies on the stereocontrolled transformation of nitrohexofuranoses into 2-oxabicyclo[2.2.1]heptanes. V: Synthesis of enantiopure methyl (1R,2R,4S)-2-amino-4-hydroxycyclopentanecarboxylate

(2010) Amalia Estévez et al.   TETRAHEDRON-ASYMMETRY

Enantiospecific synthesis of the sugar amino acid (2S,5S)-5-(aminomethyl)-tetrahydrofuran-2-carboxylic acid

(2010) María Laura Uhrig et al.   TETRAHEDRON-ASYMMETRY

Stereochemistry of terpene derivatives. Part 7: Novel rigidified amino acids from (+)-3-carene designed as chiral GABA analogues

(2010) Kamila Gajcy et al.   TETRAHEDRON-ASYMMETRY

Constrained cycloalkyl analogues of glutamic acid: stereocontrolled synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740) and its 6-phosphonic acid analogue

(2010) Jerzy Krysiak et al.   TETRAHEDRON-ASYMMETRY

Stereoselective synthesis of pinane-based β- and γ-amino acids via conjugate addition of lithium amides and nitromethane

(2010) Zsolt Szakonyi et al.   TETRAHEDRON-ASYMMETRY

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5–6 fused rings as alternative S1 moieties

(2009) Kenji Yoshikawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preliminary SAR analysis of novel antiproliferative N6,5′-bis-ureidoadenosine derivatives

(2009) Matt A. Peterson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

(2009) Michael P. DeNinno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and structure–activity relationships of pentanedioic acid diamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type I

(2009) Didier Roche et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Backbone Regulation Mimicry by β-Peptidic Foldamers: Formation of a 10-Helix in a Mixed 6-Strand/14-Helix Conformational Pool

(2009) Bharatam Jagadeesh et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metal-Catalyzed Derivatization of Cα-Tetrasubstituted Amino Acids and Their Use in the Synthesis of Cyclic Peptides

(2009) Andreas Grauer et al.   Chemistry-An Asian Journal

New Concise Route to 2-Amino-3-hydroxycycloalkanecarboxylic Acids by Imidate-Mediated Intramolecular Conjugate Addition

(2009) Yoshitaka Matsushima et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3,4-Fused Bicyclic β-Lactams and Their Transformation into Methylcis-3-Aminotetrahydrofuran-2-carboxylates

(2009) Erika Leemans et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The CMP-legionaminic acid pathway in Campylobacter: Biosynthesis involving novel GDP-linked precursors

(2009) Ian C Schoenhofen et al.   GLYCOBIOLOGY

Synthesis of 3-Fluoro-Oxetane δ-Amino Acids

(2009) Susana Dias Lucas et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Toward the Back-Up of Boceprevir (SCH 503034): Discovery of New Extended P4-Capped Ketoamide Inhibitors of Hepatitis C Virus NS3 Serine Protease with Improved Potency and Pharmacokinetic Profiles

(2009) Stéphane L. Bogen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Conformationally Constrained Diaminodicarboxylic Acid Derivatives

(2009) Robin A. Weatherhead et al.   JOURNAL OF ORGANIC CHEMISTRY

Cross-Metathesis Reactions as an Efficient Tool in the Synthesis of Fluorinated Cyclic β-Amino Acids§

(2009) Santos Fustero et al.   JOURNAL OF ORGANIC CHEMISTRY

Stable Right- and Left-Handed Peptide Helices containing Cα-Tetrasubstituted α-Amino Acids

(2009) Andreas A. Grauer et al.   JOURNAL OF ORGANIC CHEMISTRY

Three-Component Assembly of Amines, Boronic Acids, and a Polyfunctionalized Furanose: A Concise Entry to Furanose-Based Carbohydrate Templates

(2009) Ana M. Gómez et al.   JOURNAL OF ORGANIC CHEMISTRY

Conformationally Restricted Nonchiral Pipecolic Acid Analogues

(2009) Dmytro S. Radchenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Theoretical and Experimental Studies on α/ε-Hybrid Peptides: Design of a 14/12-Helix from Peptides with Alternating (S)-C-Linked Carbo-ε-amino Acid [(S)-ε-Caa(x)] andl-Ala

(2009) Gangavaram V. M. Sharma et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Solution Conformation of Homo-β-peptides Consisting ofN-Mannofuranosyl-3-ulosonic acids

(2009) Manuel Andreini et al.   JOURNAL OF ORGANIC CHEMISTRY

An Efficient Route to AcyclicC-Nucleosides and Fused-Ring Analogues of Uridine fromexo-Glycals

(2009) Gérald Enderlin et al.   JOURNAL OF ORGANIC CHEMISTRY

Cyclobutane Amino Acid Analogues of Furanomycin Obtained by a Formal [2 + 2] Cycloaddition Strategy Promoted by Methylaluminoxane

(2009) Alberto Avenoza et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Structural Characterization of Sialic Acid−Glutamic Acid Hybrid Foldamers as Conformational Surrogates of α-2,8-Linked Polysialic Acid

(2009) Jonel P. Saludes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereospecific Synthesis of Conformationally Constrained γ-Amino Acids: New Foldamer Building Blocks That Support Helical Secondary Structure

(2009) Li Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Lithium(I) Binaphtholate Salts for the Enantioselective Direct Mannich-Type Reaction with a Change of Syn/Anti and Absolute Stereochemistry

(2009) Manabu Hatano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes

(2009) Guojian Liao et al.   Microbial Cell Factories

Synthesis of pyrrolidine homoazasugars and 3,4-dihydroxy-5-hydroxymethylprolines using aldol additions of metalated bislactim ethers to 2,4-O-ethylidene-d-erythroses

(2009) Olga Blanco et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

α,γ-Cyclic peptide ensembles with a hydroxylated cavity

(2009) César Reiriz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis of FR901483

(2009) Cheryl A. Carson et al.   ORGANIC LETTERS

Stereocontrolled synthesis of (5+5), (5+6) and (6+6) 3-spiropseudonucleosides

(2009) Consolación Gasch et al.   TETRAHEDRON

Synthesis of 5-substituted-3,4-dihydroxycyanopyrrolidines. An easy access to polyhydroxyprolines

(2009) Marina Moura et al.   TETRAHEDRON

An alternative synthesis of Tamiflu®: a synthetic challenge and the identification of a ruthenium-catalyzed dihydroxylation route

(2009) Kenzo Yamatsugu et al.   TETRAHEDRON

An improved synthesis of a fluorescent gabapentin–choline conjugate for single molecule detection

(2009) Haitao Wu et al.   TETRAHEDRON LETTERS

Parallel kinetic resolution of tert-butyl (RS)-6-alkyl-cyclohex-1-ene-carboxylates for the asymmetric synthesis of 6-alkyl-substituted cishexacin derivatives

(2009) Stephen G. Davies et al.   TETRAHEDRON-ASYMMETRY

Stereocontrolled transformation of nitrohexofuranoses into cyclopentylamines via 2-oxabicyclo[2.2.1]heptanes. III: synthesis of enantiopure methyl (1S,2S,3R,4S,5R)-2-amino-3,4,5-trihydroxycyclopentanecarboxylate

(2009) Fernando Fernández et al.   TETRAHEDRON-ASYMMETRY

Carbon-branched δ-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds

(2009) Michela I. Simone et al.   TETRAHEDRON-ASYMMETRY

Efficient synthesis of 3,4- and 4,5-dihydroxy-2-amino-cyclohexanecarboxylic acid enantiomers

(2009) Gabriella Benedek et al.   TETRAHEDRON-ASYMMETRY

Stereoselective synthesis of 2-azetidinylglycine and aminopyrrolidone derivatives from Garner’s aldehyde

(2009) Latibuddin Thander et al.   TETRAHEDRON-ASYMMETRY

Pyranocyclopropanyl sugar amino acids, a new class of constrained (di)peptide isosteres

(2009) Martijn D.P. Risseeuw et al.   TETRAHEDRON-ASYMMETRY

Stereocontrolled transformation of nitrohexofuranoses into cyclopentylamines via 2-oxabicyclo[2.2.1]heptanes. IV: Synthesis of enantiopure methyl (1S,2R,3R,4R,5S)-5-benzyloxycarbonylamino-2,3-isopropylidenedioxy-4-methoxycyclopentanecarboxylate

(2009) Fernando Fernández et al.   TETRAHEDRON-ASYMMETRY

Iodine-mediated ring-closing iodoamination with concomitant N-debenzylation for the asymmetric synthesis of polyhydroxylated pyrrolidines

(2009) Stephen G. Davies et al.   TETRAHEDRON-ASYMMETRY

β-Peptidic Peptidomimetics

(2008) Dieter Seebach et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis of both enantiomers of hydroxypipecolic acid derivatives equivalent to 5-azapyranuronic acids and evaluation of their inhibitory activities against glycosidases

(2008) Yuichi Yoshimura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Stereoselective synthesis and biological evaluation of 3,4-diaminocyclohexanecarboxylic acid derivatives as factor Xa inhibitors

(2008) Tsutomu Nagata et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition

(2008) Paul V. Fish et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent, exceptionally selective, orally bioavailable inhibitors of TNF-α Converting Enzyme (TACE): Novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1′ substituents

(2008) Gregory R. Ott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oxadiazolone bioisosteres of pregabalin and gabapentin

(2008) David J. Wustrow et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stereochemical Assignment and First Synthesis of the Core of Miharamycin Antibiotics

(2008) Filipa Marcelo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Simple and quantitative mechanochemical preparation of the first zinc and copper complexes of the neuroleptic drug gabapentin

(2008) Dario Braga et al.   CRYSTENGCOMM

Catalytic Hydrogenation of 5,6-Dihydro-4H-1,2-oxazines Bearing a Functionalized Methylene Group at C-3

(2008) Alexey Yu. Sukhorukov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3‐Methoxyoxetane δ‐Amino Acids with D‐lyxo, D‐ribo, and D‐arabino Configurations

(2008) Susana Dias Lucas et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

“Diversity Oriented Synthesis” of Functionalized Chiral Tetrahydropyridines: Potential GABA Receptor Agonists and Azasugars from Natural Amino Acids via a Sequential Baylis−Hillman Reaction and RCM Protocol

(2008) Palakodety Radha Krishna et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore†

(2008) Hai Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A β-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase

(2008) Jennifer M. Mason et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Novel G-Protein-Coupled Receptor 54 Agonists with Resistance to Degradation by Matrix Metalloproteinase

(2008) Kenji Tomita et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of Diaminopimelate Epimerase from Arabidopsis thaliana, an Amino Acid Racemase Critical for l-Lysine Biosynthesis

(2008) Bindu Pillai et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis, Conformational Analysis and Biological Studies of Cyclic Cationic Antimicrobial Peptides Containing Sugar Amino Acids

(2008) Tushar Kanti Chakraborty et al.   JOURNAL OF ORGANIC CHEMISTRY

Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid

(2008) Kevin E. Henegar   JOURNAL OF ORGANIC CHEMISTRY

Studies Directed toward the Development of Amide-Linked RNA Mimics: Synthesis of the Monomeric Building Blocks

(2008) Tushar Kanti Chakraborty et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Formation of a Functionalized Dipeptide Isostere by Zinc Carbenoid-Mediated Chain Extension†

(2008) Weimin Lin et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Azumamide E and Sugar Amino Acid-Containing Analogue

(2008) Srivari Chandrasekhar et al.   JOURNAL OF ORGANIC CHEMISTRY

Structure-Activity Relationship Study of 8-amino-2,8-dideoxy-β -KDO, a Potent CMP-KDO Synthetase Inhibitor

(2008) Hayamitsu Adachi et al.   Letters in Drug Design & Discovery

Synthesis of Sugar β-Amino Acid Containing Homooligomeric Cyclic Peptides

(2008) Manuel Andreini et al.   LETTERS IN ORGANIC CHEMISTRY

Synthesis and conformational studies of peptides from new C-linked carbo-β-amino acids (β-Caas) with anomeric methylamino- and difluorophenyl moieties

(2008) Gangavaram V. M. Sharma et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Regioselective intramolecular ring closure of 2-amino-6-bromo-2,6-dideoxyhexono-1,4-lactones to 5- or 6-membered iminuronic acid analogues: synthesis of 1-deoxymannojirimycin and 2,5-dideoxy-2,5-imino-d-glucitol

(2008) Birgitte M. Malle et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Direct Asymmetric Intramolecular Alkylation of β-Alkoxy-α-amino Esters via Memory of Chirality

(2008) Katsuhiko Moriyama et al.   ORGANIC LETTERS

Iodocyclization of Chiral CF3-Allylmorpholinones: A Versatile Strategy for the Synthesis of Enantiopure α-Tfm-Prolines and α-Tfm-Dihydroxyprolines

(2008) Caroline Caupène et al.   ORGANIC LETTERS

Stereoselective synthesis of hydroxylated β-aminocyclohexanecarboxylic acids

(2008) Loránd Kiss et al.   TETRAHEDRON

Stereoselective synthesis of azetidine-derived glutamate and aspartate analogues from chiral azetidin-3-ones

(2008) Antonio Carlos B. Burtoloso et al.   TETRAHEDRON

Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity

(2008) Thomas A. Brandt et al.   TETRAHEDRON

Nucleoside derived amino acids (NDA) in foldamer chemistry: synthesis and conformational studies of homooligomers of modified AZT

(2008) S. Chandrasekhar et al.   TETRAHEDRON LETTERS

Hydroxylated C-branched pyrrolidines, C-branched prolines and C-branched piperidines from a 2-C-methyl sugar lactone; efficient azide displacement of a tertiary triflate with inversion of configuration

(2008) Filipa P. da Cruz et al.   TETRAHEDRON LETTERS

Regio- and stereoselective synthesis of constrained enantiomeric β-amino acid derivatives

(2008) Zsolt Szakonyi et al.   TETRAHEDRON-ASYMMETRY

Oxetane amino acids: synthesis of tetrameric and hexameric carbopeptoids derived from l-ribo 4-(aminomethyl)-oxetan-2-carboxylic acid

(2008) Beatrice Lopez-Ortega et al.   TETRAHEDRON-ASYMMETRY

The iodolactone approach to enantiopure oxiranes of constrained chiral cyclic β-amino acids

(2008) Olivier Songis et al.   TETRAHEDRON-ASYMMETRY

Efficient and stereoselective synthesis of (2S,3S,4S)-3,4-dihydroxyglutamic acid via intramolecular epoxidation

(2008) Hyeonjeong Kim et al.   TETRAHEDRON-ASYMMETRY

α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)

(2007) Gregory R. Ott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chimeric (α-amino acid + nucleoside-β-amino acid)npeptide oligomers show sequence specific DNA/RNA recognition

(2007) Khirud Gogoi et al.   CHEMICAL COMMUNICATIONS

Peptides derived from nucleoside β-amino acids form an unusual 8-helix

(2007) Richard Threlfall et al.   CHEMICAL COMMUNICATIONS

Cis-Configured Aziridines Are New Pseudo-Irreversible Dual-Mode Inhibitors ofCandida albicans Secreted Aspartic Protease 2

(2007) Björn Degel et al.   ChemMedChem

Novel N-(phosphonomethyl) glycine derivatives: Design, characterization and biological activity

(2007) Emilia D. Naydenova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Versatile Synthesis of Free andN-Benzyloxycarbonyl-Protected 2,2-Disubstituted Taurines

(2007) Boyuan Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Diels–Alder Reaction of Aminodienes with a Nonracemic Acrylate Bound to Rink Resin: A Comparison of These Reactions with Their Solution-State Analogues

(2007) Olivier Songis et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Rapid and Efficient Synthesis of Dysiherbaine and Analogues to Explore Structure−Activity Relationships

(2007) Makoto Sasaki et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis ofepi-Oxetin via a Serine-Derived 2-Methyleneoxetane

(2007) Marisa L. Blauvelt et al.   JOURNAL OF ORGANIC CHEMISTRY

A general and efficient stereoselective synthesis of γ-azido-tetrahydrofuran carboxylic acids from glycals

(2007) P. Venkat Reddy et al.   TETRAHEDRON

Rapid access to CF3-containing heterocycles

(2007) Adrian P. Dobbs et al.   TETRAHEDRON LETTERS