Peptide and peptoid foldamers in medicinal chemistry

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

(2011) Erinna F. Lee et al.   CHEMBIOCHEM

New Lead Structures in Antifungal Drug Discovery

(2011) Chunquan Sheng et al.   CURRENT MEDICINAL CHEMISTRY

Broad Distribution of Energetically Important Contacts across an Extended Protein Interface

(2011) Lisa M. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hairpin Folding Behavior of Mixed α/β-Peptides in Aqueous Solution

(2011) George A. Lengyel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational Design of a β-Peptide That Targets Transmembrane Helices

(2011) Scott J. Shandler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Extraordinarily Robust Polyproline Type I Peptoid Helices Generatedviathe Incorporation of α-Chiral AromaticN-1-Naphthylethyl Side Chains

(2011) Joseph R. Stringer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyelectrolyte Multilayers Fabricated from Antifungal β-Peptides: Design of Surfaces that Exhibit Antifungal Activity Against Candida albicans

(2010) Amy J. Karlsson et al.   BIOMACROMOLECULES

Antimicrobial, Hemolytic, and Cytotoxic Activities of β-Peptoid-Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs

(2010) Christian A. Olsen et al.   CHEMBIOCHEM

Bridged β3-Peptide Inhibitors of p53-hDM2 Complexation: Correlation between Affinity and Cell Permeability

(2010) Arjel D. Bautista et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers

(2010) Ki Tae Nam et al.   NATURE MATERIALS

Effect of Sequence and Structural Properties on 14-Helical β-Peptide Activity againstCandida albicansPlanktonic Cells and Biofilms

(2009) Amy J. Karlsson et al.   ACS Chemical Biology

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

(2009) Erinna F. Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

β-Peptides with improved affinity for hDM2 and hDMX

(2009) Elizabeth A. Harker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of a β3-peptide HIV fusion inhibitor with improved potency in live cells

(2009) Arjel D. Bautista et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

(2009) Frederic Heitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inversion of the Configuration of a Single Stereocenter in a β-Heptapeptide Leads to Drastic Changes in its Interaction with Phospholipid Bilayers

(2009) Toshinori Shimanouchi et al.   CHEMBIOCHEM

Cell-Permeable β-Peptide Inhibitors of p53/hDM2 Complexation

(2009) Elizabeth A. Harker et al.   CHEMBIOCHEM

Peptoid-Peptide Hybrid Backbone Architectures

(2009) Christian A. Olsen   CHEMBIOCHEM

Inhibition of γ-Secretase Activity by Helical β-Peptide Foldamers

(2009) Yuki Imamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Silico Improvement of β3-Peptide Inhibitors of p53•hDM2 and p53•hDMX

(2009) Julien Michel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems

(2009) Benjamin C. Gorske et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Preliminary Survey of the Peptoid Folding Landscape

(2009) Glenn L. Butterfoss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and biological mimicry of protein surface recognition by  / -peptide foldamers

(2009) W. S. Horne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomimicry of Surfactant Protein C

(2008) Nathan J. Brown et al.   ACCOUNTS OF CHEMICAL RESEARCH

Foldamers with Heterogeneous Backbones

(2008) W. Seth Horne et al.   ACCOUNTS OF CHEMICAL RESEARCH

Sequence-Based Design of α/β-Peptide Foldamers That Mimic BH3 Domains

(2008) W. Seth Horne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of Herpes Simplex Virus Type 1 Infection by Cationic  -Peptides

(2008) R. Akkarawongsa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of Hydrophobic Helix Length and Side Chain Chemistry on Biomimicry in Peptoid Analogues of SP-C†

(2008) Nathan J. Brown et al.   BIOCHEMISTRY

A peptoid antagonist of VEGF Receptor 2 recognizes a ‘hotspot’ in the extracellular domain distinct from the hormone-binding site

(2008) D. Gomika Udugamasooriya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues

(2008) D. Gomika Udugamasooriya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antimicrobial Activities of Twenty Lysine-Peptoid Hybrids against Clinically Relevant Bacteria and Fungi

(2008) Trine S. Ryge et al.   CHEMOTHERAPY

Peptoid architectures: elaboration, actuation, and application

(2008) Barney Yoo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Contemporary strategies for the stabilization of peptides in the α-helical conformation

(2008) Laura K Henchey et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Exploration of Structure−Activity Relationships among Foldamer Ligands for a Specific Protein Binding Site via Parallel and Split-and-Mix Library Synthesis

(2008) Justin K. Murray et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Artificial Chemokines: Combining Chemistry and Molecular Biology for the Elucidation of Interleukin-8 Functionality

(2008) Ralf David et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity

(2008) D. Gomika Udugamasooriya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligo(N-aryl glycines): A New Twist on Structured Peptoids

(2008) Neel H. Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly

(2008) W. S. Horne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

(2008) N. P. Chongsiriwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY