Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature

A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells

(2015) Li Lin et al.   NEOPLASIA

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

(2013) Mi-Jung Kim et al.   CANCER LETTERS

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45

(2012) Ryohei Wakahara et al.   GENES TO CELLS

XZH-5 Inhibits STAT3 Phosphorylation and Enhances the Cytotoxicity of Chemotherapeutic Drugs in Human Breast and Pancreatic Cancer Cells

(2012) Aiguo Liu et al.   PLoS One

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

(2012) Malabika Sen et al.   Cancer Discovery

XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells

(2011) Yan Liu et al.   APOPTOSIS

STAT3 activation in monocytes accelerates liver cancer progression

(2011) Wen-Yong Wu et al.   BMC CANCER

STAT-3 Inhibitors: State of the Art and New Horizons for Cancer Treatment

(2011) A. Lavecchia et al.   CURRENT MEDICINAL CHEMISTRY

Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3

(2011) Fang-Ming Gu   WORLD JOURNAL OF GASTROENTEROLOGY

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries

(2010) Martin Hintersteiner et al.   ACS Chemical Biology

STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma

(2010) A Horiguchi et al.   BRITISH JOURNAL OF CANCER

Signal transducer and activator of transcription 3 inhibitors: a patent review

(2010) Brent DG Page et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein

(2009) Steven Fletcher et al.   Biochemistry and Cell Biology

Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities

(2009) Steven Fletcher et al.   CHEMBIOCHEM

Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism

(2009) Ellisa Parker-Athill et al.   JOURNAL OF NEUROIMMUNOLOGY

Crystal structure of unphosphorylated STAT3 core fragment

(2008) Zhiyong Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lack of toxicity of a STAT3 decoy oligonucleotide

(2008) Malabika Sen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

STAT3 as a target for inducing apoptosis in solid and hematological tumors

(2008) Khandaker Al Zaid Siddiquee et al.   CELL RESEARCH

A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

(2008) L.-Y. Kong et al.   CLINICAL CANCER RESEARCH

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS