In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

α-Helix mimetics: Outwards and upwards

(2013) Madura K.P. Jayatunga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Suppression of Tumor Growth by Designed Dimeric Epidithiodiketopiperazine Targeting Hypoxia-Inducible Transcription Factor Complex

(2013) Ramin Dubey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells

(2013) Elena Miranda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

(2013) Thomas H Scheuermann et al.   Nature Chemical Biology

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

(2013) S. Kushal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptidomimetic targeting of critical androgen receptor–coregulator interactions in prostate cancer

(2013) Preethi Ravindranathan et al.   Nature Communications

Fine-Tuning Multiprotein Complexes Using Small Molecules

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

Plucking the high hanging fruit: A systematic approach for targeting protein–protein interactions

(2012) Monika Raj et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors

(2012) Yan Xia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Minimalist and universal peptidomimetics

(2011) Eunhwa Ko et al.   CHEMICAL SOCIETY REVIEWS

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors

(2010) Andrea L. Jochim et al.   ACS Chemical Biology

Disrupting protein–protein interactions with non-peptidic, small molecule α-helix mimetics

(2010) Christopher G Cummings et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A complex task? Direct modulation of transcription factors with small molecules

(2010) Angela N Koehler   CURRENT OPINION IN CHEMICAL BIOLOGY

Transcriptional Switches: Chemical Approaches to Gene Regulation

(2010) Lori W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligooxopiperazines as Nonpeptidic α-Helix Mimetics

(2010) Petra Tošovská et al.   ORGANIC LETTERS

Transient Protein-Protein Interactions: Structural, Functional, and Network Properties

(2010) James R. Perkins et al.   STRUCTURE

Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database

(2009) Alícia P. Higueruelo et al.   Chemical Biology & Drug Design

Direct Inhibition of Hypoxia-Inducible Transcription Factor Complex with Designed Dimeric Epidithiodiketopiperazine

(2009) Katherine M. Block et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Synthesis, and Evaluation of an α-Helix Mimetic Library Targeting Protein−Protein Interactions

(2009) Alex Shaginian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Hypoxia Inducible Factor 1—Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

(2009) Laura K. Henchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

(2009) Peter Fraisl et al.   NATURE REVIEWS DRUG DISCOVERY

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

(2009) Yair Benita et al.   NUCLEIC ACIDS RESEARCH