Hepatitis regulation by the inflammasome signaling pathway

Monocytes Activate Natural Killer Cells via Inflammasome-Induced Interleukin 18 in Response to Hepatitis C Virus Replication

(2014) Elisavet Serti et al.   GASTROENTEROLOGY

Hepatic Immune Regulation and Its Involvement in Viral Hepatitis Infection

(2014) Percy A. Knolle et al.   GASTROENTEROLOGY

Immune Responses to HCV and Other Hepatitis Viruses

(2014) Su-Hyung Park et al.   IMMUNITY

Interferon Therapy of Chronic Hepatitis B

(2014) Maurizia Rossana Brunetto et al.   INTERVIROLOGY

Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation

(2014) Kassandra Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Downregulation of Interleukin-18-Mediated Cell Signaling and Interferon Gamma Expression by the Hepatitis B Virus e Antigen

(2014) S. Jegaskanda et al.   JOURNAL OF VIROLOGY

Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation

(2014) Soo Jin Yang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic

(2014) Kareem Hassan   WORLD JOURNAL OF GASTROENTEROLOGY

Natural history of chronic hepatitis B: Phases in a complex relationship

(2014) Catherine MN Croagh   WORLD JOURNAL OF GASTROENTEROLOGY

HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon

(2014) Michael A. Chattergoon et al.   PLoS Pathogens

An update on HDV: virology, pathogenesis and treatment

(2013) Mónica V Alvarado-Mora et al.   ANTIVIRAL THERAPY

Liver abnormalities in drug and substance abusers

(2013) Puraskar Pateria et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome

(2013) Ali A Abdul-Sater et al.   EMBO REPORTS

Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B

(2013) Dian-Lei Wu et al.   HUMAN IMMUNOLOGY

Interleukin-1 and Tumor Necrosis Factor-α Trigger Restriction of Hepatitis B Virus Infection via a Cytidine Deaminase Activation-induced Cytidine Deaminase (AID)

(2013) Koichi Watashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alcoholic liver disease: Pathogenesis, management, and novel targets for therapy

(2013) Eric S Orman et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The involvement of NLRX1 and NLRP3 in the development of nonalcoholic steatohepatitis in mice

(2013) Yu-Gang Wang et al.   Journal of the Chinese Medical Association

Hepatitis C Virus Induces Interleukin-1  (IL-1 )/IL-18 in Circulatory and Resident Liver Macrophages

(2013) S. Shrivastava et al.   JOURNAL OF VIROLOGY

Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

(2013) David A. DeSantis et al.   MEDIATORS OF INFLAMMATION

Regulation of hepatic innate immunity by hepatitis C virus

(2013) Stacy M Horner et al.   NATURE MEDICINE

Convergent pathways that cause hepatic fibrosis in NASH

(2013) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice

(2013) Tim Hendrikx et al.   PLoS One

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

Negative regulation of NLRP3 inflammasome signaling

(2013) Shuzhen Chen et al.   Protein & Cell

Interleukin-18 and IL-18 Binding Protein

(2013) Charles A. Dinarello et al.   Frontiers in Immunology

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Large hepatitis delta antigen activates STAT-3 and NF-κB via oxidative stress

(2012) V. Williams et al.   JOURNAL OF VIRAL HEPATITIS

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

The role of innate immunity in HBV infection

(2012) Qiuju Han et al.   Seminars in Immunopathology

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Systematic review: epidemiology of hepatitis C genotype 6 and its management

(2011) D. T. Chao et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

From virus to inflammation: Mechanisms of RIG-I-induced IL-1β production

(2011) Hendrik Poeck et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

(2011) Antonio Bertoletti et al.   GUT

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Hepatitis C virus activates interleukin-1  via caspase-1-inflammasome complex

(2011) D. Burdette et al.   JOURNAL OF GENERAL VIROLOGY

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice

(2011) Yehuda Kamari et al.   JOURNAL OF HEPATOLOGY

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY

High Plasma Interleukin-18 Levels Mark the Acute Phase of Hepatitis C Virus Infection

(2011) Michael A. Chattergoon et al.   JOURNAL OF INFECTIOUS DISEASES

Hepatitis D virus-specific cytokine responses in patients with chronic hepatitis delta before and during interferon alfa-treatment

(2011) Jan Grabowski et al.   LIVER INTERNATIONAL

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Epidemiology and Outcome of Hepatitis C Relapse in Transplant Recipients

(2011) M. Angelico   TRANSPLANTATION PROCEEDINGS

Inflammasome Up-Regulation and Activation in Dysferlin-Deficient Skeletal Muscle

(2010) Rashmi Rawat et al.   AMERICAN JOURNAL OF PATHOLOGY

Evolving epidemiology of hepatitis C virus

(2010) D. Lavanchy   CLINICAL MICROBIOLOGY AND INFECTION

Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C

(2010) Elena Lima-Cabello et al.   CLINICAL SCIENCE

Hepatitis Delta: Immunopathogenesis and Clinical Challenges

(2010) Jan Grabowski et al.   DIGESTIVE DISEASES

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

The Genotypes of IL-1 beta and MMP-3 are Associated with the Prognosis of HCV-related Hepatocellular Carcinoma

(2010) Kinya Okamoto et al.   INTERNAL MEDICINE

Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice

(2010) M. Lech et al.   INTERNATIONAL IMMUNOLOGY

The Role of the Inflammasome in Nonmyeloid Cells

(2010) Amir S. Yazdi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Inflammasome-mediated regulation of hepatic stellate cells

(2009) Azuma Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Proapoptotic IL-18 in patients with chronic hepatitis C treated with pegylated interferon-alpha

(2009) He YingLi et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Early kinetics of innate and adaptive immune responses during hepatitis B virus infection

(2009) P Fisicaro et al.   GUT

Endotoxemia and gut barrier dysfunction in alcoholic liver disease

(2009) Radhakrishna Rao   HEPATOLOGY

Expression and function of the NALP3 inflammasome in rheumatoid synovium

(2009) Laeticia Kolly et al.   IMMUNOLOGY

Hepatitis C virus cell entry: role of lipoproteins and cellular receptors

(2009) M. E. Burlone et al.   JOURNAL OF GENERAL VIROLOGY

Serum Concentrations of Interleukin 1ss, CXCL10, and Interferon-  in Mixed Cryoglobulinemia Associated with Hepatitis C Infection

(2009) A. ANTONELLI et al.   JOURNAL OF RHEUMATOLOGY

Hepatitis delta virus large antigen sensitizes to TNF-α-induced NF-κB signaling

(2009) Chul-Yong Park et al.   MOLECULES AND CELLS

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

(2009) K. L. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor

(2009) David M. Owen et al.   VIROLOGY

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

(2009) Artur Kaul et al.   PLoS Pathogens

Prointerleukin-18 Is Activated by Meprin βin Vitroandin Vivoin Intestinal Inflammation

(2008) Sanjita Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis E: An emerging awareness of an old disease

(2008) R.H. Purcell et al.   JOURNAL OF HEPATOLOGY

Fas / FasL system, IL-1β expression and apoptosis in chronic HBV and HCV liver disease

(2008) M. Bortolami et al.   JOURNAL OF VIRAL HEPATITIS

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abrogation of the Antifibrotic Effects of Natural Killer Cells/Interferon-γ Contributes to Alcohol Acceleration of Liver Fibrosis

(2007) Won–Il Jeong et al.   GASTROENTEROLOGY

Alcohol induced hepatic fibrosis: Role of acetaldehyde

(2007) Tommaso Mello et al.   MOLECULAR ASPECTS OF MEDICINE

Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α

(2007) Jennifer M. Loftis et al.   NEUROSCIENCE LETTERS