A Repurposed Drug for Brain Cancer: Enhanced Atovaquone Amorphous Solid Dispersion by Combining a Spontaneously Emulsifying Component with a Polymer Carrier

Nanoemulsion of atovaquone as a promising approach for treatment of acute and chronic toxoplasmosis

(2018) Sanaz Jafarpour Azami et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery – An update

(2018) Scott V. Jermain et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule

(2017) Justine Thiry et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Development of stability-enhanced ternary solid dispersions via combinations of HPMCP and Soluplus ® processed by hot melt extrusion

(2017) Ahmad B. Albadarin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fabrication and Optimization of Self-Microemulsions to Improve the Oral Bioavailability of Total Flavones of Hippophaë rhamnoides L

(2017) Ruixue Guo et al.   JOURNAL OF FOOD SCIENCE

Reactive Melt Extrusion To Improve the Dissolution Performance and Physical Stability of Naproxen Amorphous Solid Dispersions

(2017) Xu Liu et al.   MOLECULAR PHARMACEUTICS

The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model

(2017) Katharine Victoria Jensen et al.   PLoS One

Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing

(2017) Min Shen et al.   Oncotarget

Using Supercritical Fluid Technology (SFT) in Preparation of Tacrolimus Solid Dispersions

(2016) Rana M. Obaidat et al.   AAPS PHARMSCITECH

Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent

(2016) M. Xiang et al.   BLOOD

Inhibition of STAT3 enhances the radiosensitizing effect of temozolomide in glioblastoma cells in vitro and in vivo

(2016) Tae Jin Han et al.   JOURNAL OF NEURO-ONCOLOGY

CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence

(2016) N Garg et al.   ONCOGENE

Improvement of solubility, dissolution and stability profile of artemether solid dispersions and self emulsified solid dispersions by solvent evaporation method

(2016) Muhammad Tayyab Ansari et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

(2016) Thomas M. Ashton et al.   Nature Communications

Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

(2016) Marco Fiorillo et al.   Oncotarget

A New Extrudable Form of Hypromellose: AFFINISOL™ HPMC HME

(2015) Siyuan Huang et al.   AAPS PHARMSCITECH

Construction and Validation of Binary Phase Diagram for Amorphous Solid Dispersion Using Flory–Huggins Theory

(2015) Krishna Bansal et al.   AAPS PHARMSCITECH

Tablets and minitablets prepared from spray-dried SMEDDS containing naproxen

(2015) Katja Čerpnjak et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The fate of paclitaxel during in vitro dispersion testing of different lipid-based formulations

(2015) K. Mohsin et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression

(2015) Gloria Perazzoli et al.   PLoS One

Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line

(2014) TADASHI ASHIZAWA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Investigation of phase diagrams and physical stability of drug–polymer solid dispersions

(2014) Jiannan Lu et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications

(2014) Jennifer Kim et al.   Cancers

In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine

(2013) Ravi Devraj et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Enhanced intestinal absorption of etoposide by self-microemulsifying drug delivery systems: Roles of P-glycoprotein and cytochrome P450 3A inhibition

(2013) Gang Zhao et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus®-based solid dispersions

(2013) Justin R. Hughey et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Early drug development predictions of glass-forming ability and physical stability of drugs

(2013) Denny Mahlin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: Polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs

(2013) Ashish L. Sarode et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Inhibition of STAT3 Enhances the Radiosensitizing Effect of Temozolomide in Malignant Glioma Cells

(2013) I. Kim et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The role of Stat3 in glioblastoma multiforme

(2013) Rodney B. Luwor et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Atovaquone versus trimethoprim-sulfamethoxazole as Pneumocystis jirovecii pneumonia prophylaxis following renal transplantation

(2012) Steven Gabardi et al.   CLINICAL TRANSPLANTATION

Overcoming sink limitations in dissolution testing: a review of traditional methods and the potential utility of biphasic systems

(2012) Daniel J. Phillips et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression

(2012) Shinji Kohsaka et al.   MOLECULAR CANCER THERAPEUTICS

Glioblastoma multiforme: Molecular characterization and current treatment strategy (Review)

(2011) XIANG ZHANG et al.   Experimental and Therapeutic Medicine

Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test

(2010) Ulrich Heigoldt et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: A potential for targeted therapy?

(2010) Claire Villalva et al.   INTERNATIONAL JOURNAL OF CANCER

STAT3 tyrosine phosphorylation influences survival in glioblastoma

(2010) Peter Birner et al.   JOURNAL OF NEURO-ONCOLOGY

Drug–Polymer Solubility and Miscibility: Stability Consideration and Practical Challenges in Amorphous Solid Dispersion Development

(2010) Feng Qian et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Oral atovaquone for the treatment of severe Pneumocystis jirovecii pneumonia in a patient with glucose-6-phosphate dehydrogenase deficiency

(2010) Emmanuel E. Douzinas et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms

(2008) Bo Tang et al.   DRUG DISCOVERY TODAY

Formulation of fast disintegrating tablets of ternary solid dispersions consisting of TPGS 1000 and HPMC 2910 or PVPVA 64 to improve the dissolution of the anti-HIV drug UC 781

(2008) Caroline Goddeeris et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Amorphous Compositions Using Concentration Enhancing Polymers for Improved Bioavailability of Itraconazole

(2008) James C. DiNunzio et al.   MOLECULAR PHARMACEUTICS

Hydroxypropyl Methylcellulose Acetate Succinate-Based Spray-Dried Dispersions: An Overview

(2008) Dwayne T. Friesen et al.   MOLECULAR PHARMACEUTICS