STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma

(2015) John de Groot et al.   Oncotarget

Epidermal Growth Factor Receptor in Glioma: Signal Transduction, Neuropathology, Imaging, and Radioresistance

(2015) Kimmo J. Hatanpaa et al.   NEOPLASIA

Astrocytic Regulation of Human Monocytic/Microglial Activation

(2014) A. M. Kostianovsky et al.   JOURNAL OF IMMUNOLOGY

Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma

(2013) C Gordziel et al.   BRITISH JOURNAL OF CANCER

Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma

(2013) TADASHI ASHIZAWA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The role of Stat3 in glioblastoma multiforme

(2013) Rodney B. Luwor et al.   JOURNAL OF CLINICAL NEUROSCIENCE

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010

(2013) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Importance of direct macrophage - Tumor cell interaction on progression of human glioma

(2012) Yoshihiro Komohara et al.   CANCER SCIENCE

Targeting EGFR for Treatment of Glioblastoma: Molecular Basis to Overcome Resistance

(2012) T. E. Taylor et al.   CURRENT CANCER DRUG TARGETS

The role of STAT3 activation in modulating the immune microenvironment of GBM

(2012) Alfred P. See et al.   JOURNAL OF NEURO-ONCOLOGY

Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway

(2012) Ke Sai et al.   JOURNAL OF NEURO-ONCOLOGY

STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression

(2012) Shinji Kohsaka et al.   MOLECULAR CANCER THERAPEUTICS

On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells

(2012) Owen D. Stechishin et al.   NEURO-ONCOLOGY

Potential Role for STAT3 Inhibitors in Glioblastoma

(2012) Christopher Jackson et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer

(2012) CANHUI JIN et al.   Experimental and Therapeutic Medicine

SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation

(2011) Carina Lindemann et al.   ACTA NEUROPATHOLOGICA

Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3

(2011) Olga A. Guryanova et al.   CANCER CELL

Enhancement of Cancer Vaccine Therapy by Systemic Delivery of a Tumor-Targeting Salmonella-Based STAT3 shRNA Suppresses the Growth of Established Melanoma Tumors

(2011) E. R. Manuel et al.   CANCER RESEARCH

Human Cytomegalovirus US28 Found in Glioblastoma Promotes an Invasive and Angiogenic Phenotype

(2011) L. Soroceanu et al.   CANCER RESEARCH

Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251

(2011) Jun Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hypoxia Potentiates Glioma-Mediated Immunosuppression

(2011) Jun Wei et al.   PLoS One

The Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Induces Apoptosis in Medulloblastoma and Glioblastoma Cells

(2011) Sarah Ball et al.   PLoS One

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol

(2010) Yu Ren et al.   BMC CANCER

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

Inhibition of STAT3 and ErbB2 Suppresses Tumor Growth, Enhances Radiosensitivity, and Induces Mitochondria-Dependent Apoptosis in Glioma Cells

(2010) Ling Gao et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Down-Regulation of Stat3 Decreases Invasion Activity and Induces Apoptosis of Human Glioma Cells

(2010) Fuxue Chen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines

(2010) Qinglin Liu et al.   JOURNAL OF NEURO-ONCOLOGY

STAT3 tyrosine phosphorylation influences survival in glioblastoma

(2010) Peter Birner et al.   JOURNAL OF NEURO-ONCOLOGY

Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells

(2010) Christian Senft et al.   JOURNAL OF NEURO-ONCOLOGY

Distinct effects of human glioblastoma immunoregulatory molecules programmed cell death ligand-1 (PDL-1) and indoleamine 2,3-dioxygenase (IDO) on tumour-specific T cell functions

(2010) Tony Avril et al.   JOURNAL OF NEUROIMMUNOLOGY

Prognostic significance and mechanism of Treg infiltration in human brain tumors

(2010) Joannes F.M. Jacobs et al.   JOURNAL OF NEUROIMMUNOLOGY

Activation of JAK/STAT signal pathway predicts poor prognosis of patients with gliomas

(2010) Yanyang Tu et al.   MEDICAL ONCOLOGY

Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway

(2010) J. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Sorafenib Induces Growth Arrest and Apoptosis of Human Glioblastoma Cells through the Dephosphorylation of Signal Transducers and Activators of Transcription 3

(2010) Fan Yang et al.   MOLECULAR CANCER THERAPEUTICS

LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model

(2009) B Fuh et al.   BRITISH JOURNAL OF CANCER

STAT3 Regulation of Glioblastoma Pathogenesis

(2009) Nuria la Iglesia et al.   CURRENT MOLECULAR MEDICINE

Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice

(2009) Leying Zhang et al.   GLIA

The role of microglia in central nervous system immunity and glioma immunology

(2009) Isaac Yang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

Mechanisms of Local Immunoresistance in Glioma

(2009) Emilia Albesiano et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

(2009) Maureen M. Sherry et al.   STEM CELLS

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

(2008) D. A. Solomon et al.   CANCER RESEARCH

Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators

(2008) H.-W. Lo et al.   CLINICAL CANCER RESEARCH

Loss of Protein Inhibitors of Activated STAT-3 Expression in Glioblastoma Multiforme Tumors: Implications for STAT-3 Activation and Gene Expression

(2008) E. C. Brantley et al.   CLINICAL CANCER RESEARCH

The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas

(2008) M. Abou-Ghazal et al.   CLINICAL CANCER RESEARCH

Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells

(2008) Jinhai Gu et al.   JOURNAL OF NEURO-ONCOLOGY

STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells

(2008) Guang-hui Li et al.   JOURNAL OF NEURO-ONCOLOGY

Deregulation of a STAT3-Interleukin 8 Signaling Pathway Promotes Human Glioblastoma Cell Proliferation and Invasiveness

(2008) N. de la Iglesia et al.   JOURNAL OF NEUROSCIENCE