Article
Pharmacology & Pharmacy
Arun Butreddy, Sandeep Sarabu, Mashan Almutairi, Srinivas Ajjarapu, Praveen Kolimi, Suresh Bandari, Michael A. Repka
Summary: This study investigates the impact of binary and ternary amorphous solid dispersions on the supersaturation kinetics of nifedipine. The results show that specific polymer combinations can delay nucleation induction time and enhance dissolution performance, potentially improving oral absorption.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Yogita M. Charde, Jasmine G. Avari
Summary: This study aimed to improve the bioavailability of artemether-lumefantrine through solid dispersion technique with hydrophilic carriers. The results showed increased solubility, reduced crystallinity, enhanced dissolution rate, and improved pharmacokinetic parameters in mice. The combination of various analytical methods successfully demonstrated the enhancement in drug properties.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sidian Zhang, Tao Wang, Jiajia Xue, Haiyan Xu, Sizhu Wu
Summary: Novel polymer excipients were designed for improving the solubility of highly crystalline drugs such as phenytoin. Quantum mechanical and Monte Carlo simulations were used to determine the optimal repeating units of NiPAm and HEAm, as well as the copolymerization ratio. Molecular dynamics simulations confirmed that the designed copolymer exhibited better dispersibility and intermolecular hydrogen bonds for phenytoin when compared to commercial PVP materials. Experimental results also validated the improvement in solubility of the designed copolymers and solid dispersions, consistent with the simulation predictions. These novel ideas and simulation technology have potential applications in drug modification and development.
Article
Pharmacology & Pharmacy
Yi Guo, Henis Patel, Aishwarya Saraswat, Kranthi Venkat Mateti, Ketan Patel, Emilio Squillante
Summary: This research aimed to enhance the solubility and dissolution rate of poorly-water soluble and heat-labile drug albendazole (ABZ) using supercritical fluid (SCF) technology. Polymer screening and solid state characterization were conducted to optimize the process and product. The results showed that the SCF batches processed at 80 degrees C, 1500 psi and 2 h resulted in substantial amorphization of ABZ, leading to improved dissolution. The SCF formulation also showed enhanced permeability compared to pure ABZ.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Madan Sai Poka, Marnus Milne, Anita Wessels, Marique Aucamp
Summary: This article discusses the feasibility of using sugars and polyols as carriers for SDs, as they possess several ideal characteristics. Recently, there has been increasing interest in the use of low-molecular-weight excipients. However, there are limited options available for safe, low molecular excipients, which opens the door again for sugars and polyols.
Article
Pharmacology & Pharmacy
Isaie Nyamba, Olivier Jennotte, Charles B. Sombie, Anna Lechanteur, Pierre-Yves Sacre, Abdoulaye Djande, Rasmane Semde, Brigitte Evrard
Summary: To exploit the therapeutic potential of ellagic acid, strategies to enhance its solubility, dissolution rate, and bioavailability are necessary. Among the pre-selected polymers, Eudragit® EPO showed the most promising results for solid dispersions of ellagic acid, with a stable supersaturated solution and significantly higher solubility. The extrudates based on this polymer also showed a high dissolution rate, and increasing the loading rate did not negatively affect drug release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Kristen N. Kelsall, Leila M. Foroughi, Derek S. Frank, Luke Schenck, Anthony LaBuda, Adam J. Matzger
Summary: The polymers used in amorphous solid dispersions have an influence on the drug loading, solubility, dissolution rate, and physical stability of crystalline drugs with low solubility. In this study, the hydrophobicity of crosslinked polyethylenimine (PEI) was investigated for the delivery of the BCS class II drug flufenamic acid. Synthetic variables for crosslinking PEI were manipulated, and benzoyl chloride was employed to increase the hydrophobicity of the crosslinked materials. The findings showed enhanced drug delivery and physical stability in acidic media, motivating the use of polymers with high functional group concentrations for ASD formation.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Arun Butreddy
Summary: Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS) is widely used in amorphous solid dispersions (ASDs) as a solubility enhancer and precipitation inhibitor or stabilizer. HPMCAS ASDs have advantages such as reduced hygroscopicity, strong drug-polymer hydrophobic interactions, and high solubilization efficiency.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Hongwei Zhang, Minglu Li, Jianmin Li, Anjali Agrawal, Ho-Wah Hui, Demin Liu
Summary: This study compared the performance of two amorphous formulation strategies: mesoporous silica via solvent impregnation, and solid dispersions by spray drying. The results showed that mesoporous silica was able to maintain amorphous fenofibrate for up to 3 months and had better flowability compared to solid dispersions. In vitro dissolution results indicated a well-controlled release of fenofibrate from mesoporous silica. This study demonstrates the potential of mesoporous silica as an alternative formulation platform to spray-dried solid dispersions for oral drug product development.
Article
Medicine, Research & Experimental
Sumit Mukesh, Prachi Joshi, Arvind K. Bansal, Mahesh Chand Kashyap, Sanjay K. Mandal, Vasant Sathe, Abhay T. Sangamwar
Summary: The study introduced a combined strategy of amorphization and salt formation for celecoxib (CEL), resulting in enhanced solubility, dissolution rate, in vivo pharmacokinetics, and physical stability. The generated amorphous salts solid dispersion (ASSD) formulations of CEL exhibited greatly improved aqueous solubility and in vivo pharmacokinetics, while remaining physically stable for nearly a year under ambient conditions. These results suggest that ASSD is a promising approach for improving the physicochemical properties and biopharmaceutical performance of CEL.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Sonali S. Bharate
Summary: Khellin, extracted from fruits and seeds of Ammi visnaga, has pharmacological activities but limited by low solubility and bioavailability. Research on binary and ternary solid dispersion formulations aims to improve its solubility and dissolution behavior, with SSB17 showing promising enhancement in solubility and pharmacokinetics.
Article
Pharmacology & Pharmacy
Xiangjun Shi, Baibai Fan, Xiyue Zhou, Qifeng Chen, Shuimei Shen, Xiaoyi Xing, Yu Deng
Summary: The study aimed to improve the solubility and dissolution of Ibrutinib by preparing amorphous solid dispersions, which showed significant enhancement in solubility and dissolution compared to crystalline Ibrutinib. The results demonstrated that amorphous solid dispersion is a promising strategy to enhance the solubility of poorly water soluble Ibrutinib.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Chemistry, Multidisciplinary
Qiao Chen, Jingyun Weng, Gabriele Sadowski, Yuanhui Ji
Summary: The influence of temperature, stirring speed, and polymeric excipients on the crystal growth kinetics of active pharmaceutical ingredients (APIs) mesalazine and allopurinol was systematically investigated using experimental measurement and a chemical potential gradient model. The results showed that the two-step chemical potential gradient model accurately modeled the API crystal growth kinetics. Excipients, such as PEG, HPMC, and PVP, played a crucial role in inhibiting API crystal growth by improving solubility and reducing the crystal growth rate. The study provided a mechanistic understanding of how polymers inhibit API crystal growth.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Pharmacology & Pharmacy
Clara E. Correa-Soto, Yi Gao, Anura S. Indulkar, Geoff G. Z. Zhang, Lynne S. Taylor
Summary: Amorphous solid dispersion formulations (ASD) are used to improve the bioavailability of poorly soluble drugs. This study investigated the addition of surfactants to atazanavir-copovidone ASDs to increase the limit of congruency (LoC). The results showed that addition of certain surfactants increased the LoC and enhanced drug release from the ASDs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Qiang Huang, Zhiren Zou, Xiaobo Li, Qinwen Xiao, Guang Liang, Wenqi Wu
Summary: The drug-amino acid co-amorphous systems and amorphous solid dispersions (ASDs) are promising methods for poorly water-soluble drugs. Poly (amino acid)-based ASDs with high drug-loading and physical stability were prepared by ball milling poly-L-lysine and polyglutamic acid with mebendazole, tadalafil, and valsartan. The dissolution rate and physical stability of the drugs were improved by the drug-poly (amino acid) ASDs. Salt formation between the drug and poly (amino acid) is not necessary for the formation of promising ASDs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Sumera Latif, Qazi Amir Ijaz, Misbah Hameed, Qurat-ul-ain Shoaib, Kanwal Fatima, Amjad Hussain, Muhammad Sohail Arshad, Nasir Abbas
Summary: By cocrystallizing with L-alanine, the physicochemical and mechanical properties of naproxen were improved; the cocrystal exhibited higher tensile strength and dissolution rate compared to naproxen, making it suitable for tablet formulation, and showed enhanced bioavailability in a model study.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Medicine, General & Internal
Muhammad Sohail Arshad, Muhammad Aslam, Shahnab Ahmad, Muhammad Kashif
Summary: This observational study conducted in Pakistan found that 13.0% of children with non-cardiac congenital defects had associated CHD, with patent ductus arteriosus and ventricular septal defect being the most common. Children with cleft lip and/or palate should be given more attention due to the high incidence of CHD in this group. Echocardiography is recommended for timely identification of any possible type of CHD.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Amna Ali, Aliyah Zaman, Elshaimaa Sayed, David Evans, Stuart Morgan, Chris Samwell, John Hall, Muhammad Sohail Arshad, Neenu Singh, Omar Qutachi, Ming-Wei Chang, Zeeshan Ahmad
Summary: EHDA technologies, such as electrospraying, have been utilized in pharmaceutical and drug delivery fields to manipulate particulate structures and meet specific application needs, showing great potential for sensitive biologics and molecules. Various parameters and modifications during the process can greatly influence the resulting particles and their applications.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Hassan Ahmad, Tahir Ali Chohan, Jahanzeb Mudassir, Prina Mehta, Bushra Yousef, Aliyah Zaman, Amna Ali, Omar Qutachi, Ming-Wei Chang, Dimitris Fatouros, Muhammad Sohail Arshad, Zeeshan Ahmad
Summary: This study aimed to develop in-situ gels containing naproxen sodium and sodium alginate. The gel formation was studied in different physiological ions, and the gel formulations were evaluated for physical attributes and drug release. In vivo studies showed the potential of the in-situ gel for sustained release of naproxen sodium and treatment of chronic inflammatory conditions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Umair Jillani, Jahanzeb Mudassir, Prina Mehta, Yasmine Alyassin, Kazem Nazari, Bushra Yousef, Mohammed Patel, Aliyah Zaman, Elshaimaa Sayed, Ming-Wei Chang, Amna Ali, Zeeshan Ahmad, Muhammad Sohail Arshad
Summary: The study aimed to develop and improve the buccal delivery of zolmitriptan succinate using mucoadhesive buccal films. The results showed that different formulation constituents had various effects on the characteristics and drug release. The use of iontophoresis and chemical penetration enhancers significantly enhanced the permeation of zolmitriptan succinate. In vivo pharmacokinetic studies revealed a higher bioavailability and rapid onset of action in the ionto group.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Mudasser Adnan, Muhammad Sohail Arshad, Hafiz Anwar-ul-Haq, Hashim Raza
Summary: This study reported trends in bacteriological spectrum and antibiotic susceptibility on blood culture in admitted pediatric cardiac patients. The blood culture positivity rate was found to be 19.9%, with Gram negative rods being the most frequently noted strains and Salmonella typhi, Coagulase Negative Staphylococcus, and Acinetobacter baumannii as common bacterial isolates responsible.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Umair Jillani, Jahanzeb Mudassir, Qazi Amir Ijaz, Sumera Latif, Nadia Qamar, Ambreen Aleem, Ejaz Ali, Khizar Abbas, Muhammad Asif Wazir, Amjad Hussain, Nasir Abbas, Muhammad Sohail Arshad
Summary: The study aimed to design and characterize mucoadhesive buccal films containing ondansetron hydrochloride (OND) using agarose (AG), hydroxypropyl methyl cellulose (HPMC), and glycerol. The buccal delivery of OND was enhanced by iontophoresis and chemical penetration enhancers. The effects of different formulation components on various parameters and drug release were investigated. The results showed a linear release profile and the relationship between polymer content and drug release. Physicochemical interactions were analyzed and no chemical interactions were found. Permeation studies revealed enhanced flux with iontophoresis and chemical enhancers. Pharmacokinetic and pharmacological studies in animals showed improved bioavailability and reduced emesis events. Histopathological examinations demonstrated no severe negative effects.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Muhammad Sohail Arshad, Maliha Mujeeb, Saman Zafar, Waheed Qamar Khan, Mohammed Patel, Bushra Yousef, Elshaimaa Sayed, Ming-Wei Chang, Zeeshan Ahmad
Summary: This study aimed to prepare piroxicam loaded polyvinyl pyrollidone (PVP) particulate mat, fabricated mat incorporated tablets and coated polyvinyl alcohol (PVA) films. The prepared formulations showed promising results in improving the solubility of poorly soluble piroxicam and oral/topical anti-inflammatory therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Muhammad Sohail Arshad, Shafaq Gulfam, Saman Zafar, Najmusama Abdul Jalil, Nadia Ahmad, Omar Qutachi, Ming-Wei Chang, Neenu Singh, Zeeshan Ahmad
Summary: This study successfully fabricated tetanus toxoid laden microneedle patches using a polymeric blend and sorbitol as a plasticizer. The patches showed uniform thickness, folding endurance, and swelling profile. In vitro and in vivo experiments demonstrated the effectiveness of these patches in delivering the vaccine and inducing immune responses.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Saman Zafar, Muhammad Sohail Arshad, Sadia Jafar Rana, Mohammed Patel, Bushra Yousef, Zeeshan Ahmad
Summary: This study aimed to fabricate various formulations of clarithromycin-loaded drug delivery systems and evaluate their physicochemical properties, drug release behavior, antimicrobial activity, and in vivo antibiofilm efficacy. The microfibers and microneedle patches demonstrated desirable morphological characteristics and drug incorporation. The formulations exhibited pH-responsive drug release profiles and showed significant antimicrobial effects against Staphylococcus aureus. The microneedle patch formulation demonstrated the highest inhibitory zone and rapid clearance of Staphylococcus aureus in infected wounds, suggesting its potential for the management of microbial biofilms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Muhammad Sohail Arshad, Saman Zafar, Sadia Jafar Rana, Kazem Nazari, Ming-Wei Chang, Zeeshan Ahmad
Summary: A study was conducted to fabricate gentamicin sulphate laden dissolving microarray patches, which can release antibiotics and exhibit antibacterial effect against various bacteria. The patches showed sharp-tipped, uniform-surfaced and equidistant microprojections.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Sohail Arshad, Saad Hussain, Saman Zafar, Sadia Jafar Rana, Nadia Ahmad, Najmusama Abdul Jalil, Zeeshan Ahmad
Summary: This study aimed to develop rabies vaccine incorporated microneedle (MN) patches and evaluate the immunogenicity of prepared formulations in combination with iontophoresis. The results showed that the MN-iontophoresis combination provided a more potent immunogenic response than conventional intramuscular injection.
PHARMACEUTICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Rukhsana Batool, Jahanzeb Mudassir, Mahtab Ahmad Khan, Saman Zafar, Sadia Jafar Rana, Nasir Abbas, Amjad Hussain, Muhammad Sohail Arshad, Sajjad Muhammad
Summary: The aim of this study was to prepare celecoxib-loaded chitosan/guar gum (CS/GG) hydrogel beads and evaluate their performance. The beads showed sustained drug release and exhibited potential for managing inflammatory conditions. The SC formulation demonstrated better therapeutic efficiency compared to the DC counterpart.
Article
Pharmacology & Pharmacy
Shiza Murad, Jahanzeb Mudassir, Sumaira Faiz, Andleeb Zahra, Faisal Usman, Muhammad Farhan, Muhammad Sohail Arshad, Nasir Abbas, Amjad Hussain, Mirza Muhammad Faran Ashraf Baig
Summary: This study aimed to enhance the bioavailability of lansoprazole by synthesizing a floating hydrogel using gum tragacanth and itaconic acid. The optimized hydrogel showed acceptable floating behavior and sustained release both in-vitro and in-vivo, extending the gastric residence time up to 24 hours.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Muhammad Sohail Arshad, Munazza Kiran, Jahanzeb Mudassir, Muhammad Farhan, Amjad Hussain, Nasir Abbas
Summary: This study aimed to design, optimize and characterize gastro retentive floating levofloxacin tablets for sustained drug delivery. The floating tablets were prepared using polymers and showed excellent floating behavior and controlled drug release kinetics. The optimized formulation exhibited prolonged floating time and appropriate drug release rate, making it suitable for the treatment of peptic ulcer.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)