Article
Pharmacology & Pharmacy
Phuong Tran, Jeong-Sook Park
Summary: Many newly discovered chemical entities in the pharmaceutical industry suffer from low aqueous solubility, leading to poor bioavailability, which poses a challenge for pharmaceutical scientists. Solid dispersion (SD) technology, particularly the use of supercritical fluid (SCF) technology, has been successful in overcoming these challenges and enhancing dissolution and bioavailability of poorly water-soluble drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Nanoscience & Nanotechnology
Mengyao Dong, Gang Wang, Xiangning Zhang, Daqing Tan, D. Jaya Prasanna Kumar, Juanna Ren, Henry Colorado, Hua Hou, Zhexenbek Toktarbay, Zhanhu Guo
Summary: Compared with unfoamed polymers, polymer foams have many advantages such as lightweight, high strength-to-weight ratio, and excellent insulation properties. The use of chemical foaming agents in conventional polymer foam preparation raises environmental issues. Supercritical fluids, known for their environmentally friendly and non-toxic characteristics, can serve as an alternative to conventional chemical foaming agents. They exhibit gas-like diffusion and liquid-like density, allowing for the production of uniform and higher-density microcellular foams.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Engineering, Environmental
Chaoping Fu, Ruili Wei, Peiyao Xu, Shiwei Luo, Chunyang Zhang, Ranjith Kumar Kankala, Shibin Wang, Xinqing Jiang, Xinhua Wei, Liming Zhang, Aizheng Chen, Ruimeng Yang
Summary: In recent years, the use of diselenide-bridged polymeric nanocomposites for drug delivery, especially in enhanced anticancer therapy, has gained significant attention. However, the high sensitivity of diselenide bonds to various stimuli limits the fabrication of such nanocomposites with high performance efficiency. This study successfully demonstrated the fabrication of ICG-loaded diselenide-containing polymeric nanoparticles using a supercritical fluid-assisted rapid synthesis approach for ROS/GSH-responsive drug delivery, showing high drug loading and encapsulation efficiency.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Eman M. Mohamed, Sathish Dharani, Mohammad T. H. Nutan, Phillip Cook, Rajendran Arunagiri, Mansoor A. Khan, Ziyaur Rahman
Summary: The aim of this study was to develop co-amorphous dispersion (CAD) formulations of tacrolimus (TAC) using sucrose acetate isobutyrate as a carrier, and compare its performance with hydroxypropyl methylcellulose (HPMC) based amorphous solid dispersion (ASD) formulation. The CAD and ASD formulations showed amorphous phase transformation of the drug and dissolved more than 85% of the drug in 90 min. No drug crystallization was observed in the formulations after storage, and no significant change in the dissolution profile was observed. The CAD and ASD formulations exhibited bioequivalence with tablet formulations and showed improved pharmacokinetic performance.
Article
Pharmacology & Pharmacy
Yong-Chul Pyo, Thu Nhan Nguyen, Ye-Seul Lee, Yeong-Eun Choi, Jeong-Sook Park
Summary: This study aimed to improve the solubility and bioavailability of esomeprazole magnesium by preparing solid dispersions using a supercritical anti-solvent process. The results showed that the solid dispersion prepared using this process exhibited higher dissolution rate and better pharmacokinetic profile compared to other formulations.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rana Obaidat, Haneen Aleih, Hadeia Mashaqbeh, Bashar Altaani, Mo'tasem M. Alsmadi, Mohammad Alnaief
Summary: Masking the bitter taste of ibuprofen using cocoa butter and supercritical fluid technology is a promising innovative approach to enhance patient acceptance, especially for children. The drug to polymer ratio, configuration of the supercritical fluid unit, and preparation method were found to be critical in the formulation of ibuprofen microparticles. Taste evaluation with human volunteers showed that microparticles containing 20% drug, processed with supercritical fluid technology, were effective in masking the bitter taste of ibuprofen.
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Maud Margrethe Brekstad Kjellin, Zarah Schaal, Tengyu Zhang, Korbinian Lobmann, Donglei Leng
Summary: This study compared the feasibility of using proteins as co-formers in amorphous solid dispersions (ASDs) with traditional synthetic polymers and a nanocrystalline formulation. The whey protein beta-lactoglobulin (BLG) demonstrated the highest glass transition temperature and improved dissolution rate and drug solubility compared to the polymer-based ASD systems and the nanocrystalline formulation.
Article
Thermodynamics
Gen-ding Yu, Jing-ling Li, Ling-zhu Gong, You-gen Chen, Liu-fang Ni, Lei Peng, Zhu-wu Jiang, Long-bin Yang, Yih-Shing Duh
Summary: This study has discovered an effective method for depolymerizing TDI char using supercritical methanol, achieving efficient destruction of the polymer. Through various experimental methods, it was found that the optimal result can be achieved at 270 degrees Celsius, and compared to other treatment methods, supercritical methanolysis has superior depolymerization capability.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Chemistry, Multidisciplinary
Nastaran Yousefi, Behrad Saeedi Saghez, Richard D. Pettipas, Timothy L. Kelly, Loren G. Kaake
Summary: The self-assembly of isotactic polypropylene films from supercritical n-pentane was studied in relation to solubility behavior, crystallinity, and morphology. It was found that pressure plays a significant role in deposition and crystalline structure, leading to a decrease in crystallinity under high pressure. A model of film growth was proposed to explain the observed phenomena involving pre-aggregation and turbulence effects.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Polymer Science
Yuxuan Zhu, Qiwen Liu, Ruizhi Zhang, Peng Cao, Guoqiang Luo, Huan Yuan, Jian Zhang, Yi Sun, Qiang Shen
Summary: In this article, a multibubble growth model of polymethyl-methacrylate (PMMA) is established based on supercritical fluid foaming method and fluid simulation. The effects of foaming conditions on the cell structures of PMMA foams are analyzed and predicted.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Food Science & Technology
Jian Zhu, Hongsheng Liu, Xingzhe Cai, Wei Wu, Zhiyi Zhu, Long Yu
Summary: This study successfully fabricated instant casein phosphopeptide (CPP) powders with micropore structures using supercritical fluid-assisted atomization (SAA) technology. The powders showed significantly decreased dissolution time and increased specific surface area, without affecting their bioactivities. The results demonstrate the promising potential of SAA technology in preparing instant polypeptide powders.
Article
Pharmacology & Pharmacy
Yi Guo, Henis Patel, Aishwarya Saraswat, Kranthi Venkat Mateti, Ketan Patel, Emilio Squillante
Summary: This research aimed to enhance the solubility and dissolution rate of poorly-water soluble and heat-labile drug albendazole (ABZ) using supercritical fluid (SCF) technology. Polymer screening and solid state characterization were conducted to optimize the process and product. The results showed that the SCF batches processed at 80 degrees C, 1500 psi and 2 h resulted in substantial amorphization of ABZ, leading to improved dissolution. The SCF formulation also showed enhanced permeability compared to pure ABZ.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Green & Sustainable Science & Technology
Lei Li, Minyi Chen, Yun Zeng, Gang Liu
Summary: Supercritical fluid extraction (SFE) is an eco-friendly technology with significant application potential in the food and nutraceutical industries. SFE has high selectivity and can be used to extract easily oxidized compounds, while minimizing the use of organic solvents and leaving no toxic residues in the product.
ADVANCED SUSTAINABLE SYSTEMS
(2022)
Article
Polymer Science
Muhammad Zaman, Asma Iqbal, Hafiz Shoaib Sarwar, Muhammad Hammad Butt, Muhammad Omer Iqbal, Naveed Nissar, Asma Mumtaz, Hafiza Yusra Nazeer, Abdulrahman Alshammari, Muhammad Shahid Riaz
Summary: In this study, solid lipid nanoparticles (SLNs) were used to develop a controlled drug delivery system (CDDS) for a lipophilic drug, tacrolimus (TCM). Poloxamer (PLX) was used as a polymer to facilitate the loading of TCM into the SLNs. Physicochemical evaluations, including particle size, surface charge, surface morphology, and drug release kinetics, were performed to characterize the prepared PLX/TCM-SLNs. The results demonstrated successful preparation of SLNs with controlled release properties.
INTERNATIONAL JOURNAL OF POLYMER SCIENCE
(2023)
Article
Polymer Science
Long Wang, Xingyuan Huang, Haifeng Liang
Summary: This article experimentally investigated the solubility and dissolution rate of supercritical CO2 in polymer melt PS at different temperatures and pressures under conical and screw agitators, and conducted numerical calculations to analyze the results. It was found that different types of agitators have different effects on gas dissolution, highlighting the importance of studying dissolution under the action of the agitator in the continuous molding of microporous plastics.
Article
Pharmacology & Pharmacy
Rana M. Obaidat, Bassam M. Tashtoush, Mohammad F. Bayan, Rana T. Al Bustami, Mohammad Alnaief
Article
Physics, Multidisciplinary
Rana Obaidat, Darryl Yu, Steve Aljawhiri, Robert Macgregor
HIGH PRESSURE RESEARCH
(2015)
Article
Pharmacology & Pharmacy
Rana Abu-Huwaij, Rana M. Obaidat, Kamal Sweidan, Yusuf Al-Hiari
Article
Pharmacology & Pharmacy
Aiman A. Obaidat, Rana M. Obaidat
ACTA PHARMACEUTICA
(2011)
Article
Chemistry, Medicinal
Rana M. Obaidat, Khouloud A. Alkhamis, Mutaz S. Salem
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2010)
Article
Chemistry, Physical
Rana Obaidat, Nawzat Al-Jbour, Khaldoun Al-Sou'd, Kamal Sweidan, Mayyas Al-Remawi, Adnan Badwan
JOURNAL OF SOLUTION CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Harry G. Sherman, Carolyn Jovanovic, Alaa Abuawad, Dong-Hyun Kim, Hilary Collins, James E. Dixon, Robert Cavanagh, Robert Markus, Snow Stolnik, Frankie J. Rawson
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2019)
Article
Endocrinology & Metabolism
Alaa Abuawad, Chidimma Mbadugha, Amir M. Ghaemmaghami, Dong-Hyun Kim
Review
Biochemistry & Molecular Biology
Wamidh H. Talib, Ahmad Riyad Alsayed, Alaa Abuawad, Safa Daoud, Asma Ismail Mahmod
Summary: Melatonin, as a pleotropic molecule, shows inhibitory effects on various types of cancer both in vitro and in vivo, mainly due to its involvement in multiple anticancer mechanisms and enhancement of conventional therapies. Clinical trials have demonstrated the effectiveness of melatonin as an adjuvant drug in cancer treatment, suggesting its promising application in the field of oncology.
Article
Pharmacology & Pharmacy
Rana M. Obaidat, Bassam M. Tashtoush, Areen S. Alshweiat
LATIN AMERICAN JOURNAL OF PHARMACY
(2017)
Article
Chemistry, Medicinal
KA Alkhamis, MS Salem, RM Obaidat
JOURNAL OF PHARMACEUTICAL SCIENCES
(2006)
Article
Chemistry, Medicinal
MNOR Caira, KA Alkhamis, RM Obaidat
JOURNAL OF PHARMACEUTICAL SCIENCES
(2004)
Article
Pharmacology & Pharmacy
AA Obaidat, RM Obaidat
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2001)