Epithelioid Hemangioendothelioma as a Model of YAP/TAZ-Driven Cancer: Insights from a Rare Fusion Sarcoma

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1

(2018) Helena J. Janse van Rensburg et al.   CANCER RESEARCH

The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis

(2018) Michael D. Deel et al.   CLINICAL CANCER RESEARCH

Epithelioid Hemangioendothelioma: Update on Diagnosis and Treatment

(2018) Ari Rosenberg et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

(2018) Sandybell Anorga et al.   FASEB JOURNAL

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis

(2018) Tetsuo Toyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant Melanoma

(2018) Min Hwan Kim et al.   Cancer Immunology Research

YAP/TAZ Activation as a Target for Treating Metastatic Cancer

(2018) Janine Warren et al.   Cancers

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism

(2017) Maria Zena Miranda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting YAP in malignant pleural mesothelioma

(2017) Wen-Qian Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Yap/Taz Deletion in Gli+Cell-Derived Myofibroblasts Attenuates Fibrosis

(2017) Ming Liang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apatinib for the treatment of pulmonary epithelioid hemangioendothelioma

(2017) Zhipeng Zheng et al.   MEDICINE

A Novel Notch–YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma

(2017) Katherine K. Slemmons et al.   MOLECULAR CANCER RESEARCH

Hepatic Epithelioid Hemangioendothelioma and Adult Liver Transplantation

(2017) Quirino Lai et al.   TRANSPLANTATION

The TAZ–miR-224–SMAD4 axis promotes tumorigenesis in osteosarcoma

(2017) Jianjun Ma et al.   Cell Death & Disease

YAP regulates PD-L1 expression in human NSCLC cells

(2017) Jinbai Miao et al.   Oncotarget

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

(2017) Jiaoyuan Jia et al.   PLoS One

TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

(2017) Satoshi Noguchi et al.   Scientific Reports

Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics

(2016) Leona A. Doyle et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Sirolimus in Advanced Epithelioid Hemangioendothelioma: A Retrospective Case-Series Analysis from the Italian Rare Cancer Network Database

(2016) Silvia Stacchiotti et al.   ANNALS OF SURGICAL ONCOLOGY

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

The roles of the Hippo pathway in cancer metastasis

(2016) Helena J. Janse van Rensburg et al.   CELLULAR SIGNALLING

Non-Photoinduced Biological Properties of Verteporfin

(2016) Floriane Gibault et al.   CURRENT MEDICINAL CHEMISTRY

Proton-sensing GPCR-YAP Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells

(2016) Hongyi Zhu et al.   International Journal of Biological Sciences

Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling

(2016) Hui Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma

(2016) Abdalla Mohamed et al.   JOURNAL OF PATHOLOGY

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeting the Hippo pathway: Clinical implications and therapeutics

(2016) Shuai Ye et al.   PHARMACOLOGICAL RESEARCH

Verteporfin, a suppressor of YAP–TEAD complex, presents promising antitumor properties on ovarian cancer

(2016) Zhengyu Li et al.   OncoTargets and Therapy

Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations

(2016) Albino Troilo et al.   Oncotarget

TAZ and YAP are frequently activated oncoproteins in sarcomas

(2016) Colleen A. Fullenkamp et al.   Oncotarget

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Thoracic Epithelioid Malignant Vascular Tumors

(2015) Todd Anderson et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The Hippo signal transduction pathway in soft tissue sarcomas

(2015) Abdalla D. Mohamed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma—a suitable treatment option: case report and review of anti-angiogenic treatment options

(2015) Valeriya Semenisty et al.   BMC CANCER

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

(2015) Carsten Gram Hansen et al.   CELL RESEARCH

CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma

(2015) Ryo Shibuya et al.   HISTOPATHOLOGY

Molecular characterization of epithelioid haemangioendotheliomas identifies novelWWTR1-CAMTA1fusion variants

(2015) Nimesh R Patel et al.   HISTOPATHOLOGY

Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein

(2015) M R Tanas et al.   ONCOGENE

Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis

(2015) T. S. Karin Eisinger-Mathason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions

(2015) Thomas Bertero et al.   Scientific Reports

Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins

(2015) Wenqi Wang et al.   Cell Reports

Combination capecitabine and bevacizumab in the treatment of metastatic hepatic epithelioid hemangioendothelioma

(2015) Augustine Lau et al.   Therapeutic Advances in Medical Oncology

A phase II study of TRC105 in patients with hepatocellular carcinoma who have progressed on sorafenib

(2015) AG Duffy et al.   United European Gastroenterology Journal

A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas

(2015) Michael D. Deel et al.   Frontiers in Oncology

Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma

(2015) Katherine K. Slemmons et al.   PLoS One

The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation

(2014) Annie M. Tremblay et al.   CANCER CELL

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

The mammalian Hippo pathway: regulation and function of YAP1 and TAZ

(2014) Manami Kodaka et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IntragenicCAMTA1deletions are associated with a spectrum of neurobehavioral phenotypes

(2014) M. Shinawi et al.   CLINICAL GENETICS

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

Epithelioid Hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases

(2014) Uta Flucke et al.   Diagnostic Pathology

Malignant vascular tumors—an update

(2014) Cristina Antonescu   MODERN PATHOLOGY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor

(2014) C. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NovelYAP1-TFE3fusion defines a distinct subset of epithelioid hemangioendothelioma

(2013) Cristina R. Antonescu et al.   GENES CHROMOSOMES & CANCER

Alveolar rhabdomyosarcoma–associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression

(2013) Lisa E.S. Crose et al.   JOURNAL OF CLINICAL INVESTIGATION

Does histology predict outcome for malignant vascular tumors of the liver?

(2013) Ryan T. Groeschl et al.   JOURNAL OF SURGICAL ONCOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of pulmonary epithelioid hemangioendothelioma with combination chemotherapy: Report of three cases and review of the literature

(2013) BO YE et al.   Oncology Letters

An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas

(2012) M. Agulnik et al.   ANNALS OF ONCOLOGY

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition

(2012) Wei Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IntragenicCAMTA1rearrangements cause non-progressive congenital ataxia with or without intellectual disability

(2012) Julien Thevenon et al.   JOURNAL OF MEDICAL GENETICS

Calcium Dependent CAMTA1 in Adult Stem Cell Commitment to a Myocardial Lineage

(2012) Barbara Muller-Borer et al.   PLoS One

CAMTA1, a 1p36 Tumor Suppressor Candidate, Inhibits Growth and Activates Differentiation Programs in Neuroblastoma Cells

(2011) K.-O. Henrich et al.   CANCER RESEARCH

Clinical Patterns and Outcome in Epithelioid Hemangioendothelioma With or Without Pulmonary Involvement

(2011) Kenneth Lau et al.   CHEST

CAMTA1 is a novel tumour suppressor regulated by miR-9/9*in glioblastoma stem cells

(2011) Daniel Schraivogel et al.   EMBO JOURNAL

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites

(2011) Costantino Errani et al.   GENES CHROMOSOMES & CANCER

Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma

(2011) M. R. Tanas et al.   Science Translational Medicine

Primary pleural epithelioid hemangioendothelioma (EHE) - two cases and review of the literature

(2010) Angeline Lazarus et al.   Clinical Respiratory Journal

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

(2009) David R. Brigstock   Journal of Cell Communication and Signaling

Epithelioid Hemangioendothelioma of Soft Tissue: A Proposal for Risk Stratification Based on 49 Cases

(2008) Andrea T. Deyrup et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Connective tissue growth factor (CTGF) and cancer progression

(2008) Chia-Yu Chu et al.   JOURNAL OF BIOMEDICAL SCIENCE