Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

(2017) Sachin H. Patel et al.   GASTROENTEROLOGY

Modulating the wnt signaling pathway with small molecules

(2017) Freddi Huan Tran et al.   PROTEIN SCIENCE

Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies

(2016) Min Hwan Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Non-Photoinduced Biological Properties of Verteporfin

(2016) Floriane Gibault et al.   CURRENT MEDICINAL CHEMISTRY

YAP/TAZ as therapeutic targets in cancer

(2016) Francesca Zanconato et al.   CURRENT OPINION IN PHARMACOLOGY

Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling

(2016) Hui Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver

(2016) Hao Yin et al.   JOURNAL OF HEPATOLOGY

Markers of Hippo-Pathway Activity in Tumor Forming Liver Lesions

(2016) Henning Reis et al.   PATHOLOGY & ONCOLOGY RESEARCH

Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells

(2016) Xiao-Yang Dai et al.   Oncotarget

Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations

(2016) Albino Troilo et al.   Oncotarget

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma

(2015) B. H. Sohn et al.   CLINICAL CANCER RESEARCH

Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine

(2015) L. Lum et al.   CURRENT MEDICINAL CHEMISTRY

Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer

(2015) Dean Yimlamai et al.   JOURNAL OF HEPATOLOGY

Knockdown of yes-associated protein inhibits proliferation and downregulates large tumor suppressor 1 expression in MHCC97H human hepatocellular carcinoma cells

(2015) CHENG WANG et al.   Molecular Medicine Reports

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver

(2015) Xiaolei Li et al.   Oncotarget

Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells

(2015) Li Ma et al.   Oncotarget

Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins

(2015) Wenqi Wang et al.   Cell Reports

Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma

(2015) Florian Ewald et al.   Journal of Cancer

Tankyrases: Structure, Function and Therapeutic Implications in Cancer

(2014) Teemu Haikarainen et al.   CURRENT PHARMACEUTICAL DESIGN

The Angiomotins - From discovery to function

(2014) Susana Moleirinho et al.   FEBS LETTERS

Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice

(2014) Junyan Tao et al.   GASTROENTEROLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

YAP activation is an early event and a potential therapeutic target in liver cancer development

(2014) Andrea Perra et al.   JOURNAL OF HEPATOLOGY

MK2206 inhibits hepatocellular carcinoma cellular proliferation via induction of apoptosis and cell cycle arrest

(2014) J.M. Wilson et al.   JOURNAL OF SURGICAL RESEARCH

Recent advances in the structure-based rational design of TNKSIs

(2014) Peng Zhan et al.   Molecular BioSystems

Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins

(2013) B.V.V.G. Reddy et al.   DEVELOPMENTAL CELL

Tankyrases as drug targets

(2013) Lari Lehtiö et al.   FEBS Journal

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor

(2013) Andrew Voronkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma

(2012) XINYING HUO et al.   ONCOLOGY REPORTS

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

E2F1 Inhibits c-Myc-Driven Apoptosis via PIK3CA/Akt/mTOR and COX-2 in a Mouse Model of Human Liver Cancer

(2008) Sara Ladu et al.   GASTROENTEROLOGY

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

(2008) Augusto Villanueva et al.   GASTROENTEROLOGY

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY