Journal
ONCOLOGY LETTERS
Volume 5, Issue 5, Pages 1491-1496Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2013.1217
Keywords
pulmonary epithelioid hemangioendothelioma; pulmonary tumors; chemotherapy; metastases
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No standard therapy for pulmonary epithelioid hemangioendothelioma (PEH) has yet been established due to the rarity of the disease, the lack of clear standards for treatment and the partial-to-complete spontaneous regression. This report describes three cases of PHE manifested as bilateral intrapulmonary masses with an initial diagnosis conducted by thoracoscopic lung biopsy. These patients demonstrated a partial response to combination chemotherapy with carboplatin, paclitaxel, bevacizumab or endostar, and an improvement in clinical status. Furthermore, we reviewed the literature regarding such patients who received chemotherapy and immunotherapy; this indicated that patients with PEH demonstrated a good partial response to chemotherapy with carboplatin, paclitaxel, bevacizumab, thalidomide and a-interferon. Overall, combination chemotherapy regimens may hold therapeutic potential for the treatment of this rare disease.
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