p53-Autophagy-Metastasis Link

Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization

(2018) Punya Bhat et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells

(2018) Javad Alizadeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic

(2018) Wei-Wei Zhang et al.   HUMAN GENE THERAPY

Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

(2018) Mija Marinković et al.   Oxidative Medicine and Cellular Longevity

Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway

(2017) Bor-Chin Cheng et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

β-asarone inhibited cell growth and promoted autophagy via P53/Bcl-2/Bclin-1 and P53/AMPK/mTOR pathways in Human Glioma U251 cells

(2017) Nanbu Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells

(2017) Yoon-Jin Lee et al.   Molecular Medicine Reports

Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells

(2017) Zhuo Yao et al.   Cell Death & Disease

Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells

(2017) Maria Saveria Gilardini Montani et al.   CELLULAR ONCOLOGY

Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B

(2017) Jian Xu et al.   Redox Biology

Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy

(2017) Zuozhang Yang et al.   EBioMedicine

Astemizole–Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis

(2016) Rekha Jakhar et al.   CANCER LETTERS

Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p in human lung adenocarcinoma A549 cells

(2016) Lei Wu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Trichosanthin-induced autophagy in gastric cancer cell MKN-45 is dependent on reactive oxygen species (ROS) and NF-κB/p53 pathway

(2016) Bin Wei et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications

(2016) Ling Zhang et al.   LEUKEMIA & LYMPHOMA

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

Autophagy in cancer metastasis

(2016) E E Mowers et al.   ONCOGENE

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

(2016) Matthias R. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway

(2016) Chien-Ju Lin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial–Mesenchymal Transition

(2016) Spencer C. Wei et al.   TRENDS IN CELL BIOLOGY

Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer

(2016) Mila Gugnoni et al.   Cell Death & Disease

COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo

(2016) Kowthar Y. Salim et al.   Oncotarget

Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53

(2015) Shengliang Zhang et al.   CANCER RESEARCH

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

(2015) David S H Liu et al.   GUT

Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells

(2015) Dan Zi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

(2015) G Grassi et al.   Cell Death & Disease

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Understanding the non-canonical pathways involved in p53-mediated tumor suppression

(2014) K. M. Hager et al.   CARCINOGENESIS

SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors

(2014) Matthieu Bertrand et al.   CELL CYCLE

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

(2014) Xiao-Hong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of cell proliferation and migration by p62 through stabilization of Twist1

(2014) L. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of p53 to Metastasis

(2014) E. Powell et al.   Cancer Discovery

Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion

(2014) R. Lock et al.   Cancer Discovery

Tumor Suppression and Promotion by Autophagy

(2014) Yenniffer Ávalos et al.   Biomed Research International

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

(2014) Mary Ann Allen et al.   eLife

p53 Family and Cellular Stress Responses in Cancer

(2014) Johanna Pflaum et al.   Frontiers in Oncology

A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction

(2013) Anna Budina-Kolomets et al.   Autophagy

Tumor Dissemination: An EMT Affair

(2013) Jean Paul Thiery et al.   CANCER CELL

Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

(2013) A. Belaid et al.   CANCER RESEARCH

Dissecting the pathways that destabilize mutant p53: The proteasome or autophagy?

(2013) Sujata Choundhury et al.   CELL CYCLE

Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma

(2013) Bo Mi Ku et al.   FASEB JOURNAL

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

P53 regulates the migration of mesenchymal stromal cells in response to the tumor microenvironment through both CXCL12-dependent and -independent mechanisms

(2013) SIANG-YO LIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

(2013) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

PRIMA-1Met/APR-246 Displays High Antitumor Activity in Multiple Myeloma By Induction of p73 and Noxa

(2013) Manujendra N. Saha et al.   MOLECULAR CANCER THERAPEUTICS

A suppression switch

(2013) Hanna Starobinets et al.   NATURE

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer

(2013) Y. Huo et al.   Cancer Discovery

p53 Controls Autoimmune Arthritis via STAT-Mediated Regulation of the Th17 Cell/Treg Cell Balance in Mice

(2012) Jin-Sil Park et al.   ARTHRITIS AND RHEUMATISM

Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation

(2012) Yiping Huang et al.   CELL CYCLE

Dietary downregulation of mutant p53 levels via glucose restriction

(2012) Olga Catalina Rodriguez et al.   CELL CYCLE

Regulation of autophagosome formation by Rho kinase

(2012) Andrzej Mleczak et al.   CELLULAR SIGNALLING

The Role of MicroRNAs in Breast Cancer Migration, Invasion and Metastasis

(2012) Joy Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

High Mobility Group Box 1 (HMGB1) Activates an Autophagic Response to Oxidative Stress

(2011) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment

(2011) Xinbing Sui et al.   Autophagy

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

(2011) Antje S. Löffler et al.   Autophagy

Functional Cooperation of RKTG with p53 in Tumorigenesis and Epithelial-Mesenchymal Transition

(2011) Y. Jiang et al.   CANCER RESEARCH

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration

(2011) W.Andrew Yeudall et al.   CARCINOGENESIS

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

p53 represses autophagy in a cell cycle-dependent fashion

(2011) Ezgi Tasdemir et al.   CELL CYCLE

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome

(2011) R. Lazova et al.   CLINICAL CANCER RESEARCH

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

Oncosuppressive Functions of Autophagy

(2010) Eugenia Morselli et al.   ANTIOXIDANTS & REDOX SIGNALING

Evidence for the interplay between JNK and p53-DRAM signaling pathways in the regulation of autophagy

(2010) Séverine Lorin et al.   Autophagy

p53 Status in Stromal Fibroblasts Modulates Tumor Growth in an SDF1-Dependent Manner

(2010) Y. Addadi et al.   CANCER RESEARCH

Rho-GTPase signaling drives melanoma cell plasticity

(2010) Victoria Sanz-Moreno et al.   CELL CYCLE

Defective autophagy control by the p53 rheostat in cancer

(2010) Lorenzo Galluzzi et al.   CELL CYCLE

New plays in the p53 theater

(2010) Yael Aylon et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells

(2010) Deepak Mittal et al.   EMBO JOURNAL

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells

(2010) L. Roger et al.   JOURNAL OF CELL SCIENCE

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy

(2010) Kathryn G Eby et al.   Molecular Cancer

Stage-specific sensitivity to p53 restoration during lung cancer progression

(2010) David M. Feldser et al.   NATURE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

(2010) R. Scherz-Shouval et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

p53 and ARF: unexpected players in autophagy

(2010) Gregor M. Balaburski et al.   TRENDS IN CELL BIOLOGY

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

mTOR regulates autophagy-associated genes downstream of p73

(2009) Jennifer M. Rosenbluth et al.   Autophagy

Role and regulation of autophagy in cancer

(2009) Ning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and metastasis: another double-edged sword

(2009) Candia M Kenific et al.   CURRENT OPINION IN CELL BIOLOGY

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

(2009) Salah Mahmoudi et al.   MOLECULAR CELL

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

A common gain of function of p53 cancer mutants in inducing genetic instability

(2009) D P Liu et al.   ONCOGENE

p53 responsive elements in human retrotransposons

(2009) C R Harris et al.   ONCOGENE

Involvement of stromal p53 in tumor-stroma interactions

(2009) Jair Bar et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The mitochondrial p53 pathway

(2008) Angelina V. Vaseva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

(2008) Min Sung Kim et al.   HUMAN PATHOLOGY

Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)

(2008) Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Cooperative effect of p21Cip1/WAF−1 and 14-3-3σ on cell cycle arrest and apoptosis induction by p14ARF

(2008) P G Hemmati et al.   ONCOGENE

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL