Understanding the non-canonical pathways involved in p53-mediated tumor suppression

TRP53 activates a global autophagy program to promote tumor suppression

(2013) Daniela Kenzelmann Broz et al.   Autophagy

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1-Trx Complex

(2013) E. Madan et al.   MOLECULAR AND CELLULAR BIOLOGY

The mutant p53 mouse as a pre-clinical model

(2013) J G Jackson et al.   ONCOGENE

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

Autophagy regulation and its role in cancer

(2013) Séverine Lorin et al.   SEMINARS IN CANCER BIOLOGY

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

Metabolic changes in cancer: beyond the Warburg effect

(2012) W. Wu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Multitasking p53 promotes necrosis

(2012) Kim Baumann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

DRAM: A phylogenetically ancient regulator of autophagy

(2011) Alfredo Criollo et al.   CELL CYCLE

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

(2011) W Gao et al.   CELL DEATH AND DIFFERENTIATION

Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer

(2011) Kyu Yeoun Won et al.   HUMAN PATHOLOGY

Metabolic regulation by p53

(2011) Oliver D. K. Maddocks et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Necroptosis: A novel therapeutic target for glioblastoma

(2010) Yu-Gang Jiang et al.   MEDICAL HYPOTHESES

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy

(2010) Kathryn G Eby et al.   Molecular Cancer

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage

(2009) H.-C. Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

(2008) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells

(2008) Monika Szeliga et al.   GLIA

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY