Iron(ii)-catalyzed C-2 cyanomethylation of indoles and pyrroles via direct oxidative cross-dehydrogenative coupling with acetonitrile derivatives

Rhodium-catalyzed C–H functionalization with N-acylsaccharins

(2017) Hongxiang Wu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Iron-Catalyzed Dehydrogenative sp3–sp2 Coupling via Direct Oxidative C–H Activation of Acetonitrile

(2017) Huimin Su et al.   ORGANIC LETTERS

Cobalt(II)-Catalyzed Oxidative C–H Arylation of Indoles and Boronic Acids

(2017) Xinju Zhu et al.   ORGANIC LETTERS

Nickel-Catalyzed C(sp2)–H/C(sp3)–H Oxidative Coupling of Indoles with Toluene Derivatives

(2017) Vineeta Soni et al.   ACS Catalysis

Expedient C–H Chalcogenation of Indolines and Indoles by Positional-Selective Copper Catalysis

(2017) Parthasarathy Gandeepan et al.   ACS Catalysis

Merger of Visible-Light Photoredox Catalysis and C–H Activation for the Room-Temperature C-2 Acylation of Indoles in Batch and Flow

(2017) Upendra K. Sharma et al.   ACS Catalysis

Iron-catalyzed cascade cyanoalkylation/radical dearomatization of N-phenylcinnamamides: access to cyanoalkylated 1-azaspiro[4.5]decanes

(2017) Honglin Zhang et al.   Organic Chemistry Frontiers

Ruthenium(II)- or Rhodium(III)-Catalyzed Grignard-Type Addition of Indolines and Indoles to Activated Carbonyl Compounds

(2016) Hyeim Jo et al.   ADVANCED SYNTHESIS & CATALYSIS

Cobalt-Catalyzed C−H Thiolation through Dehydrogenative Cross-Coupling

(2016) Tobias Gensch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical-promoted site-specific cross dehydrogenative coupling of heterocycles with nitriles

(2016) Zhong-Quan Liu et al.   CHEMICAL COMMUNICATIONS

Mild metal-catalyzed C–H activation: examples and concepts

(2016) T. Gensch et al.   CHEMICAL SOCIETY REVIEWS

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Synergistic Heterobimetallic Manifold for Expedient Manganese(I)-Catalyzed C−H Cyanation

(2016) Weiping Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iridium(III)-Catalyzed Regioselective Carbenoid Insertion C-H Alkylation by α-Diazotized Meldrum's Acid

(2016) Honggui Lv et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis, Radiolabeling, and Biological Evaluation of 5-Hydroxy-2-[18F]fluoroalkyl-tryptophan Analogues as Potential PET Radiotracers for Tumor Imaging

(2016) Aristeidis Chiotellis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Palladium-catalysed direct C-2 methylation of indoles

(2016) Daoquan Tu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Method for Direct Synthesis of α-Cyanomethyl-β-dicarbonyl Compounds with Acetonitrile and 1,3-Dicarbonyls

(2016) Chenyang Wang et al.   ORGANIC LETTERS

Cobalt(III)-Catalyzed Regio- and Stereoselective α-Fluoroalkenylation of Arenes with gem-Difluorostyrenes

(2016) Lingheng Kong et al.   ORGANIC LETTERS

Unified Strategy for Nickel-Catalyzed C-2 Alkylation of Indoles through Chelation Assistance

(2016) Vineeta Soni et al.   ACS Catalysis

Rhodium(III)-Catalyzed Selective CH Cyanation of Indolines and Indoles with an Easily Accessible Cyano Source

(2015) Neeraj Kumar Mishra et al.   ADVANCED SYNTHESIS & CATALYSIS

Cationic Rhodium(III)-Catalyzed Direct C-2 Carboxamidation of Indoles with IsocyanatesviaCH Bond Functionalization

(2015) Jun Xu et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed Cyanomethylation of Allylic Alcohols with Concomitant 1,2-Aryl Migration: Efficient Synthesis of Functionalized Ketones Containing an α-Quaternary Center

(2015) Ala Bunescu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Intermolecular Carboetherification of Unactivated Alkenes by Alkyl Nitriles and Alcohols

(2015) Claire Chatalova-Sazepin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Alkenylations with Alkenyl Acetates, Phosphates, Carbonates, and Carbamates by Cobalt Catalysis at 23 °C

(2015) Marc Moselage et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A radical anti-Markovnikov addition of alkyl nitriles to simple alkenes via selective sp3 C–H bond functionalization

(2015) Zejiang Li et al.   CHEMICAL COMMUNICATIONS

Cp*Rh(iii) and Cp*Ir(iii)-catalysed redox-neutral C–H arylation with quinone diazides: quick and facile synthesis of arylated phenols

(2015) Shang-Shi Zhang et al.   CHEMICAL COMMUNICATIONS

Manganese catalyzed C–H functionalization of indoles with alkynes to synthesize bis/trisubstituted indolylalkenes and carbazoles: the acid is the key to control selectivity

(2015) Lijun Shi et al.   CHEMICAL COMMUNICATIONS

Oxidative radical 1,2-alkylarylation of alkenes with α-C(sp3)–H bonds of acetonitriles involving 1,2-aryl migration

(2015) Yang Li et al.   CHEMICAL COMMUNICATIONS

Strategies for the asymmetric functionalization of indoles: an update

(2015) Renato Dalpozzo   CHEMICAL SOCIETY REVIEWS

Ru-Catalysed CH Arylation of Indoles and Pyrroles with Boronic Acids: Scope and Mechanistic Studies

(2015) Carina Sollert et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper Acetate–DMSO Promoted Methylthiolation of Arenes and Heteroarenes

(2015) Poonam Sharma et al.   JOURNAL OF ORGANIC CHEMISTRY

Rh(III)-Catalyzed C–H Amidation of Indoles with Isocyanates

(2015) Taejoo Jeong et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium Catalyzed C2-Selective Cyanation of Indoles and Pyrroles

(2015) Manthena Chaitanya et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Direct C2-Benzylation of Indoles with Alkylarenes

(2015) Hui-Jun Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Fe-promoted radical cyanomethylation/arylation of arylacrylamides to access oxindoles via cleavage of the sp3 C–H of acetonitrile and the sp2 C–H of the phenyl group

(2015) Changduo Pan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Functionalized Epoxides by Copper-Catalyzed Alkylative Epoxidation of Allylic Alcohols with Alkyl Nitriles

(2015) Ala Bunescu et al.   ORGANIC LETTERS

Cobalt(III)-Catalyzed C–H Alkynylation with Bromoalkynes under Mild Conditions

(2015) Nicolas Sauermann et al.   ORGANIC LETTERS

Cobalt(III)-Catalyzed C2-Selective C–H Alkynylation of Indoles

(2015) Zhuo-Zhuo Zhang et al.   ORGANIC LETTERS

Rhodium-catalysed C(sp2)–C(sp2) bond formation via C–H/C–F activation

(2015) Panpan Tian et al.   Nature Communications

Air-Stable Carbonyl(pentamethylcyclopentadienyl)cobalt Diiodide Complex as a Precursor for Cationic (Pentamethylcyclopentadienyl)cobalt(III) Catalysis: Application for Directed C-2 Selective CH Amidation of Indoles

(2014) Bo Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

Visible Light-Induced γ-Alkoxynitrile SynthesisviaThree- Component Alkoxycyanomethylation of Alkenes

(2014) Hong Yi et al.   ADVANCED SYNTHESIS & CATALYSIS

Rhodium(III)-Catalyzed Regioselective Direct C-2 Alkenylation of Indoles Assisted by the Removable N-(2-Pyrimidyl) Group

(2014) Binwei Gong et al.   ADVANCED SYNTHESIS & CATALYSIS

An Efficient Rhodium/Oxygen Catalytic System for Oxidative Heck Reaction of Indoles and AlkenesviaCH Functionalization

(2014) Lei Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

Cobalt-Catalyzed CH Cyanation of Arenes and Heteroarenes

(2014) Jie Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed Decarbonylative Direct C2-Arylation of Indoles with Aryl Carboxylic Acids

(2014) Lingjuan Zhang et al.   ChemCatChem

Radical cascade cyanomethylation of activated alkenes to construct cyano substituted oxindoles

(2014) Juan Li et al.   CHEMICAL COMMUNICATIONS

Rh(i)-catalyzed decarbonylative direct C2-olefination of indoles with vinyl carboxylic acids

(2014) Lingjuan Zhang et al.   CHEMICAL COMMUNICATIONS

C–H Functionalization in the Synthesis of Amino Acids and Peptides

(2014) Anaïs F. M. Noisier et al.   CHEMICAL REVIEWS

Arene C–H functionalisation using a removable/modifiable or a traceless directing group strategy

(2014) Fengzhi Zhang et al.   CHEMICAL SOCIETY REVIEWS

Co(III)-Catalyzed C–H Activation/Formal SN-Type Reactions: Selective and Efficient Cyanation, Halogenation, and Allylation

(2014) Da-Gang Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium(iii)-catalyzed regioselective C2-amidation of indoles with N-(2,4,6-trichlorobenzoyloxy)amides and its synthetic application to the development of a novel potential PPARγ modulator

(2014) Jingjing Shi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mild Rh(III)-Catalyzed Direct C–H Bond Arylation of (Hetero)Arenes with Arylsilanes in Aqueous Media

(2014) Ming-Zhu Lu et al.   ORGANIC LETTERS

Recent advances in directed C–H functionalizations using monodentate nitrogen-based directing groups

(2014) Min Zhang et al.   Organic Chemistry Frontiers

Cp*CoIII-Catalyzed C2-Selective Addition of Indoles to Imines

(2013) Tatsuhiko Yoshino et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design of Potent Poxvirus Inhibitors of the Heterodimeric Processivity Factor Required for Viral Replication

(2013) Manunya Nuth et al.   JOURNAL OF MEDICINAL CHEMISTRY

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization

(2012) Percia Beatrice Arockiam et al.   CHEMICAL REVIEWS

Indoles in Multicomponent Processes (MCPs)

(2012) Morteza Shiri   CHEMICAL REVIEWS

Total Synthesis and Evaluation of Vinblastine Analogues Containing Systematic Deep-Seated Modifications in the Vindoline Subunit Ring System: Core Redesign

(2012) Kristin D. Schleicher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mild Double Allylboration Reactions of Nitriles and Acid Anhydrides Using Potassium Allyltrifluoroborate

(2012) Timothy R. Ramadhar et al.   JOURNAL OF ORGANIC CHEMISTRY

Iron-Catalyzed Aromatic Amination for Nonsymmetrical Triarylamine Synthesis

(2012) Takuji Hatakeyama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Update 1 of: Synthesis and Functionalization of Indoles Through Palladium-Catalyzed Reactions

(2011) Sandro Cacchi et al.   CHEMICAL REVIEWS

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

Towards mild metal-catalyzed C–H bond activation

(2011) Joanna Wencel-Delord et al.   CHEMICAL SOCIETY REVIEWS

Iron-Catalyzed CH Bond Activation for the ortho-Arylation of Aryl Pyridines and Imines with Grignard Reagents

(2011) Naohiko Yoshikai et al.   Chemistry-An Asian Journal

Iron-Catalyzed Stereospecific Activation of Olefinic C–H Bonds with Grignard Reagent for Synthesis of Substituted Olefins

(2011) Laurean Ilies et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety

(2010) Anna J. Kochanowska-Karamyan et al.   CHEMICAL REVIEWS

Dopamine Receptor Ligands. Part 18:(1) Modification of the Structural Skeleton of Indolobenzazecine-Type Dopamine Receptor Antagonists

(2010) Dina Robaa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iron-Mediated Direct Suzuki−Miyaura Reaction: A New Method for theortho-Arylation of Pyrrole and Pyridine

(2010) Jun Wen et al.   ORGANIC LETTERS

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

Iron-Catalyzed C(sp3)C(sp3) Bond Formation through C(sp3)H Functionalization: A Cross-Coupling Reaction of Alcohols with Alkenes

(2009) Shu-Yu Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Functionalization of Indoles in a New Dimension

(2009) Marco Bandini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

(2009) Denise A. Colby et al.   CHEMICAL REVIEWS

Highly Selective Biaryl Cross-Coupling Reactions between Aryl Halides and Aryl Grignard Reagents: A New Catalyst Combination ofN-Heterocyclic Carbenes and Iron, Cobalt, and Nickel Fluorides

(2009) Takuji Hatakeyama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Indole Cytosolic Phospholipase A2α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib

(2008) John C. McKew et al.   JOURNAL OF MEDICINAL CHEMISTRY