Palladium-catalysed direct C-2 methylation of indoles

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

(2016) Kevin W. Kuntz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regioselective oxidative Pd-catalysed coupling of alkylboronic acids with pyridin-2-yl-substituted heterocycles

(2015) Julian Wippich et al.   CHEMICAL COMMUNICATIONS

Iron-Catalyzed C(sp2)H and C(sp3)H Methylations of Amides and Anilides

(2015) Karolina Graczyk et al.   CHEMISTRY-A EUROPEAN JOURNAL

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues

(2015) Andrew T. Bockus et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aerobic Copper-Catalyzed O-Methylation with Methylboronic Acid

(2015) Clare E. Jacobson et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Radical Methylation/C–H Amination/Oxidation Cascade for the Synthesis of Quinazolinones

(2015) Yajie Bao et al.   JOURNAL OF ORGANIC CHEMISTRY

Rh(III)-Catalyzed C–H Alkylation of Arenes Using Alkylboron Reagents

(2015) He Wang et al.   ORGANIC LETTERS

Efficient Ruthenium-Catalyzed N-Methylation of Amines Using Methanol

(2015) Tuan Thanh Dang et al.   ACS Catalysis

Iridium-catalyzed methylation of indoles and pyrroles using methanol as feedstock

(2015) Shu-Jie Chen et al.   RSC Advances

Rhodium-Catalyzed Decarbonylative Direct C2-Arylation of Indoles with Aryl Carboxylic Acids

(2014) Lingjuan Zhang et al.   ChemCatChem

Lead Optimization Studies of Cinnamic Amide EP2 Antagonists

(2014) Thota Ganesh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

(2014) Neelu Kaila et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nickel-Catalyzed Reductive Methylation of Alkyl Halides and Acid Chlorides with Methyl p-Tosylate

(2014) Zhuye Liang et al.   ORGANIC LETTERS

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(I)-Catalyzed Redox-Economic Cross-Coupling of Carboxylic Acids with Arenes Directed by N-Containing Groups

(2013) Fei Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)–H Bonds with Alkyl Iodides

(2013) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed N-Methylation of Amides and O-Methylation of Carboxylic Acids by Using Peroxides as the Methylating Reagents

(2013) Qinqin Xia et al.   ORGANIC LETTERS

Mild Palladium-Catalyzed C–H Alkylation Using Potassium Alkyltrifluoroborates in Combination with MnF3

(2013) Sharon R. Neufeldt et al.   ORGANIC LETTERS

Palladium-Catalyzed CH Oxidation of Isoquinoline N-Oxides: Selective Alkylation with Dialkyl Sulfoxides and Halogenation with Dihalo sulfoxides

(2012) Bo Yao et al.   ADVANCED SYNTHESIS & CATALYSIS

S-Adenosyl-Methionine-Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications

(2012) Anna-Winona Struck et al.   CHEMBIOCHEM

Methyl Effects on Protein–Ligand Binding

(2012) Cheryl S. Leung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diazine Indole Acetic Acids as Potent, Selective, and Orally Bioavailable Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

(2012) Neelu Kaila et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death

(2012) Michael W. Robinson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Methane: a new frontier in organometallic chemistry

(2012) Vincent N. Cavaliere et al.   Chemical Science

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Pd-Catalyzed ortho-Methylation of Acetanilides via Directed C-H Activation

(2011) Min-Jung Jang et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

The Methylation Effect in Medicinal Chemistry

(2011) Eliezer J. Barreiro et al.   CHEMICAL REVIEWS

Guiding principles for site selective and stereoselective intermolecular C–H functionalization by donor/acceptor rhodium carbenes

(2011) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

Palladium-Catalyzed Coupling of Arene C–H Bonds with Methyl- and Arylboron Reagents Assisted by the Removable 2-Pyridylsulfinyl Group

(2011) José A. Romero-Revilla et al.   JOURNAL OF ORGANIC CHEMISTRY

Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery

(2011) Hui-Xiong Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cobalt-Catalyzed Coupling of Alkyl Grignard Reagent with Benzamide and 2-Phenylpyridine Derivatives through Directed C–H Bond Activation under Air

(2011) Quan Chen et al.   ORGANIC LETTERS

Direct Alkylation of Heteroaryls Using Potassium Alkyl- and Alkoxymethyltrifluoroborates

(2011) Gary A. Molander et al.   ORGANIC LETTERS

Palladium-Catalyzed Alkylation ofortho-C(sp2)–H Bonds of Benzylamide Substrates with Alkyl Halides

(2011) Yingsheng Zhao et al.   ORGANIC LETTERS

A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases

(2011) T. L. Grove et al.   SCIENCE

Minisci reactions: Versatile CH-functionalizations for medicinal chemists

(2011) Matthew A. J. Duncton   MedChemComm

Asymmetric Deprotonation ofN-Boc Piperidine: React IR Monitoring and Mechanistic Aspects

(2010) Darren Stead et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RlmN and Cfr are Radical SAM Enzymes Involved in Methylation of Ribosomal RNA

(2010) Feng Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds

(2010) Dmitry Shabashov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocatalytic Friedel-Crafts Alkylation Using Non-natural Cofactors

(2009) Harald Stecher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct palladium-catalyzed alkenylation, benzylation and alkylation of ethyl oxazole-4-carboxylate with alkenyl-, benzyl- and alkyl halides

(2009) Cécile Verrier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pd(II)-Catalyzed Cross-Coupling of sp3C−H Bonds with sp2and sp3Boronic Acids Using Air as the Oxidant

(2008) Dong-Hui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Methylation of Aryl C−H Bond by Using Peroxides

(2008) Yuhua Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY