Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird’s Eye View

Recognition of viral and self-antigens by T H 1 and T H 1/T H 17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses

(2017) Moira Paroni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti-JCV antibody serostatus and longitudinal evaluation in a Portuguese Multiple Sclerosis population

(2017) I. Correia et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients

(2017) Qi Wu et al.   JOURNAL OF IMMUNOLOGY

Update on disease-modifying therapies for multiple sclerosis

(2017) Diana L Vargas et al.   JOURNAL OF INVESTIGATIVE MEDICINE

CD4/CD8 ratio during natalizumab treatment in multiple sclerosis patients

(2017) Antonio Carotenuto et al.   JOURNAL OF NEUROIMMUNOLOGY

PD-1 gene polymorphic variation is linked with first symptom of disease and severity of relapsing-remitting form of MS

(2017) Edyta Pawlak-Adamska et al.   JOURNAL OF NEUROIMMUNOLOGY

Progressive multifocal leukoencephalopathy in patients treated with fumaric acid esters: a review of 19 cases

(2017) Robbert-Jan Gieselbach et al.   JOURNAL OF NEUROLOGY

Anti-JCV serology during natalizumab treatment: Review and meta-analysis of 17 independent patient cohorts analyzing anti-John Cunningham polyoma virus sero-conversion rates under natalizumab treatment and differences between technical and biological sero-converters

(2017) Nicholas Schwab et al.   Multiple Sclerosis Journal

Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation

(2017) Veit Rothhammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?

(2017) Jens Geginat et al.   TRENDS IN IMMUNOLOGY

Association Between BKPyV Serotype I Antibody Level and Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

(2017) Francesca Rossi et al.   VIRAL IMMUNOLOGY

Anti-JCV serology during natalizumab treatment: Review and meta-analysis of 17 independent patient cohorts analyzing anti-John Cunningham polyoma virus sero-conversion rates under natalizumab treatment and differences between technical and biological sero-converters

(2017) Nicholas Schwab et al.   Multiple Sclerosis Journal

IL-10: A Multifunctional Cytokine in Viral Infections

(2017) José M. Rojas et al.   Journal of Immunology Research

Classifying PML risk with disease modifying therapies

(2017) Joseph R. Berger   Multiple Sclerosis and Related Disorders

Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation

(2017) Dylan A. Galloway et al.   Annals of Clinical and Translational Neurology

Dimethyl fumarate alters B-cell memory and cytokine production in MS patients

(2017) Matthew D. Smith et al.   Annals of Clinical and Translational Neurology

Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature

(2016) Christa S. Zerbe et al.   CLINICAL INFECTIOUS DISEASES

GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis

(2016) J P Hussman et al.   GENES AND IMMUNITY

Fingolimod therapy modulates circulating B cell composition, increases B regulatory subsets and production of IL-10 and TGFβ in patients with Multiple Sclerosis

(2016) Shiri Blumenfeld et al.   JOURNAL OF AUTOIMMUNITY

Dimethyl Fumarate Treatment Mediates an Anti-Inflammatory Shift in B Cell Subsets of Patients with Multiple Sclerosis

(2016) Rui Li et al.   JOURNAL OF IMMUNOLOGY

Balancing the immune response in the brain: IL-10 and its regulation

(2016) Diogo Lobo-Silva et al.   Journal of Neuroinflammation

JC polyomavirus expression and bell-shaped regulation of its SF2/ASF suppressor during the follow-up of multiple sclerosis patients treated with natalizumab

(2016) Elena Uleri et al.   JOURNAL OF NEUROVIROLOGY

Reassessing the risk of natalizumab-associated PML

(2016) Joseph R. Berger et al.   JOURNAL OF NEUROVIROLOGY

Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy

(2016) Kenta Takahashi et al.   JOURNAL OF VIROLOGY

PML during dimethyl fumarate treatment of multiple sclerosis: How does lymphopenia matter?

(2016) Klaus Lehmann-Horn et al.   NEUROLOGY

JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection

(2016) Keith A. Wharton et al.   PLoS One

Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells

(2016) Ilker Kudret Sariyer et al.   PLoS One

Immunomodulatory effects of exosomes produced by virus-infected cells

(2016) Juraj Petrik   TRANSFUSION AND APHERESIS SCIENCE

Circulating MicroRNAs: Potential and Emerging Biomarkers for Diagnosis of Human Infectious Diseases

(2016) Parmila Verma et al.   Frontiers in Microbiology

Regulatory T Cells: Molecular Actions on Effector Cells in Immune Regulation

(2016) Asiel Arce-Sillas et al.   Journal of Immunology Research

Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases

(2016) Zaidoon Al-Jaderi et al.   Frontiers in Immunology

Progressive multifocal leukoencephalopathy in an immunocompetent patient

(2016) Nicolien M. van der Kolk et al.   Annals of Clinical and Translational Neurology

Human Polyomavirus Receptor Distribution in Brain Parenchyma Contrasts with Receptor Distribution in Kidney and Choroid Plexus

(2015) Sheila A. Haley et al.   AMERICAN JOURNAL OF PATHOLOGY

Single-nucleotide polymorphism of Toll-like receptor 4 and interleukin-10 in response to interferon-based therapy in Egyptian chronic hepatitis C patients

(2015) Nermin Abdel Hamid Sadik et al.   ARCHIVES OF VIROLOGY

Gap junctional shuttling of miRNA — A novel pathway of intercellular gene regulation and its prospects in clinical application

(2015) Heiko Lemcke et al.   CELLULAR SIGNALLING

Influence of fingolimod on basic lymphocyte subsets frequencies in the peripheral blood of multiple sclerosis patients – preliminary study

(2015) Julia Rudnicka et al.   Central European Journal of Immunology

Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases

(2015) C. Skevaki et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

High interindividual variability in the CD4/CD8 T cell ratio and natalizumab concentration levels in the cerebrospinal fluid of patients with multiple sclerosis

(2015) A. Harrer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Novel syndromes associated with JC virus infection of neurons and meningeal cells

(2015) Dhanashri P. Miskin et al.   CURRENT OPINION IN NEUROLOGY

Expression of BKV and JCV encoded microRNA in human cerebrospinal fluid, plasma and urine

(2015) Tuuli Pietilä et al.   JOURNAL OF CLINICAL VIROLOGY

Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis

(2015) Tessa Dhaeze et al.   JOURNAL OF IMMUNOLOGY

Opportunistic DNA Recombination With Epstein-Barr Virus at Sites of Control Region Rearrangements Mediating JC Virus Neurovirulence

(2015) Margaret J. Wortman et al.   JOURNAL OF INFECTIOUS DISEASES

DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner

(2015) Geoffrey O. Gillard et al.   JOURNAL OF NEUROIMMUNOLOGY

Fingolimod induces neuroprotective factors in human astrocytes

(2015) Franziska S. Hoffmann et al.   Journal of Neuroinflammation

Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation

(2015) Maria Antonietta Mazzola et al.   Journal of Neuroinflammation

Rituximab treatment did not aggravate ongoing progressive multifocal leukoencephalopathy in a patient with multiple sclerosis

(2015) F. Asztely et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity

(2015) Luisa J. Ströh et al.   JOURNAL OF VIROLOGY

Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients

(2015) Erin E Longbrake et al.   Multiple Sclerosis Journal

PML in a Patient without Severe Lymphocytopenia Receiving Dimethyl Fumarate

(2015) Dennis J. Nieuwkamp et al.   NEW ENGLAND JOURNAL OF MEDICINE

PML in a Patient with Lymphocytopenia Treated with Dimethyl Fumarate

(2015) Thorsten Rosenkranz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Broadly neutralizing human monoclonal JC polyomavirus VP1–specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy

(2015) Ivan Jelcic et al.   Science Translational Medicine

T cell exhaustion during persistent viral infections

(2015) Shannon M. Kahan et al.   VIROLOGY

Molecular interplay between T-Antigen and splicing factor, arginine/serine-rich 1 (SRSF1) controls JC virus gene expression in glial cells

(2015) Michael Craigie et al.   Virology Journal

Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients

(2015) Erin E Longbrake et al.   Multiple Sclerosis Journal

The Protective Role of HLA-DRB113 in Autoimmune Diseases

(2015) Andreia Bettencourt et al.   Journal of Immunology Research

IFN-Gamma Inhibits JC Virus Replication in Glial Cells by Suppressing T-Antigen Expression

(2015) Francesca Isabella De-Simone et al.   PLoS One

A fatal case of JC virus meningitis presenting with hydrocephalus in a human immunodeficiency virus-seronegative patient

(2014) Shruti P. Agnihotri et al.   ANNALS OF NEUROLOGY

Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy

(2014) Tatiana Plavina et al.   ANNALS OF NEUROLOGY

High-resolution melting analysis for mutation scanning in the non-coding control region of JC polyomavirus from patients with progressive multifocal leukoencephalopathy

(2014) Kazuo Nakamichi et al.   ARCHIVES OF VIROLOGY

The interplay between Epstein–Barr virus and B lymphocytes: implications for infection, immunity, and disease

(2014) Olivia L. Hatton et al.   IMMUNOLOGIC RESEARCH

Therapeutic uses of anti- 4-integrin (anti-VLA-4) antibodies in multiple sclerosis

(2014) N. Schwab et al.   INTERNATIONAL IMMUNOLOGY

Human glial chimeric mice reveal astrocytic dependence of JC virus infection

(2014) Yoichi Kondo et al.   JOURNAL OF CLINICAL INVESTIGATION

VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells

(2014) Tilman Schneider-Hohendorf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

(2014) T. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis

(2014) Douglas Kazutoshi Sato et al.   JOURNAL OF NEUROIMMUNOLOGY

Lymphocyte Gene Expression and JC Virus Noncoding Control Region Sequences Are Linked with the Risk of Progressive Multifocal Leukoencephalopathy

(2014) L. J. Marshall et al.   JOURNAL OF VIROLOGY

Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF

(2014) Clemens Warnke et al.   Multiple Sclerosis Journal

Differential effects of fingolimod on B-cell populations in multiple sclerosis

(2014) Masakazu Nakamura et al.   Multiple Sclerosis Journal

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Fingolimod Increases CD39-Expressing Regulatory T Cells in Multiple Sclerosis Patients

(2014) Nathalie Muls et al.   PLoS One

Compositional Changes of B and T Cell Subtypes during Fingolimod Treatment in Multiple Sclerosis Patients: A 12-Month Follow-Up Study

(2014) Nele Claes et al.   PLoS One

Circulating human microRNAs are not linked to JC polyomavirus serology or urinary viral load in healthy subjects

(2014) Ole Lagatie et al.   Virology Journal

Viral miRNAs in plasma and urine divulge JC polyomavirus infection

(2014) Ole Lagatie et al.   Virology Journal

Regulation of gap junction channels by infectious agents and inflammation in the CNS

(2014) Paul Castellano et al.   Frontiers in Cellular Neuroscience

JC Polyomavirus Infection Is Strongly Controlled by Human Leucocyte Antigen Class II Variants

(2014) Emilie Sundqvist et al.   PLoS Pathogens

Immune cells after prolonged Natalizumab therapy: implications for effectiveness and safety

(2013) S. Marousi et al.   ACTA NEUROLOGICA SCANDINAVICA

Polyomavirus JC in the Context of Immunosuppression: A Series of Adaptive, DNA Replication-Driven Recombination Events in the Development of Progressive Multifocal Leukoencephalopathy

(2013) Edward M. Johnson et al.   Clinical & Developmental Immunology

Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages

(2013) Maria Teixeira-Coelho et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis

(2013) Elizabeth P. Sampaio et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multiplex qPCR assay for ultra sensitive detection of JCV DNA with simultaneous identification of genotypes that discriminates non-virulent from virulent variants

(2013) Caroline F. Ryschkewitsch et al.   JOURNAL OF CLINICAL VIROLOGY

Fingolimod Modulates Peripheral Effector and Regulatory T Cells in MS Patients

(2013) Laura D. Serpero et al.   Journal of Neuroimmune Pharmacology

Dimethyl fumarate regulates histone deacetylase expression in astrocytes

(2013) Sergey Kalinin et al.   JOURNAL OF NEUROIMMUNOLOGY

5-HT2 Receptors Facilitate JC Polyomavirus Entry

(2013) B. Assetta et al.   JOURNAL OF VIROLOGY

Immunological Hallmarks of JC Virus Replication in Multiple Sclerosis Patients on Long-Term Natalizumab Therapy

(2013) H. Hendel-Chavez et al.   JOURNAL OF VIROLOGY

Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis

(2013) Milan Buc   MEDIATORS OF INFLAMMATION

Differential microRNA expression in blood in multiple sclerosis

(2013) Helle Bach Søndergaard et al.   Multiple Sclerosis Journal

Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy

(2013) G Francis et al.   Multiple Sclerosis Journal

Relapse of multiple sclerosis in a patient retaining CCR7-expressing T cells in CSF under fingolimod therapy

(2013) Akiko Yokoseki et al.   Multiple Sclerosis Journal

T-cell response against varicella-zoster virus in fingolimod-treated MS patients

(2013) M. E. Ricklin et al.   NEUROLOGY

JC Viremia in Natalizumab-Treated Patients with Multiple Sclerosis

(2013) Eugene O. Major et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased B Cell and Cytotoxic NK Cell Proportions and Increased T Cell Responsiveness in Blood of Natalizumab-Treated Multiple Sclerosis Patients

(2013) Johan Mellergård et al.   PLoS One

Fingolimod (FTY720) Stimulates Ca2+/Calcineurin Signaling in Fission Yeast

(2013) Kanako Hagihara et al.   PLoS One

SF2/ASF binding region within JC virus NCCR limits early gene transcription in glial cells

(2013) Elena Uleri et al.   Virology Journal

Epigenetic regulation of polyomavirus JC

(2013) Hassen S Wollebo et al.   Virology Journal

Imaging the microanatomy of astrocyte–T-cell interactions in immune-mediated inflammation

(2013) Carlos Barcia et al.   Frontiers in Cellular Neuroscience

Increased Program Cell Death–1 Expression on T Lymphocytes of Patients With Progressive Multifocal Leukoencephalopathy

(2012) Chen Sabrina Tan et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

IL-10-Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection

(2012) A. Das et al.   JOURNAL OF IMMUNOLOGY

Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood–brain barrier through paracellular transmigration and ERK activation

(2012) Divya Sagar et al.   Journal of Neuroinflammation

Human polyomavirus JC reactivation and pathogenetic mechanisms of progressive multifocal leukoencephalopathy and cancer in the era of monoclonal antibody therapies

(2012) A. Bellizzi et al.   JOURNAL OF NEUROVIROLOGY

Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

(2012) Gary Bloomgren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Decrease in VLA-4 Expression and Functional Impairment of Dendritic Cells during Natalizumab Therapy in Patients with Multiple Sclerosis

(2012) Clara de Andrés et al.   PLoS One

JC Virus Encephalopathy Is Associated with a Novel Agnoprotein-Deletion JCV Variant

(2012) Xin Dang et al.   PLoS One

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS

(2012) Ken Flanagan et al.   PLoS One

Effect of Natalizumab on Circulating CD4+ T-Cells in Multiple Sclerosis

(2012) Lars Börnsen et al.   PLoS One

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Cooperative roles of NF-κB and NFAT4 in polyomavirus JC regulation at the KB control element

(2012) Hassen S. Wollebo et al.   VIROLOGY

Changes in JC Virus-Specific T Cell Responses during Natalizumab Treatment and in Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

(2012) Molly R. Perkins et al.   PLoS Pathogens

Current and emerging therapies in multiple sclerosis: a systematic review

(2012) Wanda Castro-Borrero et al.   Therapeutic Advances in Neurological Disorders

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

(2011) Nikolaos A. Patsopoulos et al.   ANNALS OF NEUROLOGY

An Identical miRNA of the Human JC and BK Polyoma Viruses Targets the Stress-Induced Ligand ULBP3 to Escape Immune Elimination

(2011) Yoav Bauman et al.   Cell Host & Microbe

Natalizumab treatment perturbs memory- and marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis

(2011) Raquel Planas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Downregulation of endothelial adhesion molecules by dimethylfumarate, but not monomethylfumarate, and impairment of dynamic lymphocyte-endothelial cell interactions

(2011) Katrin Wallbrecht et al.   EXPERIMENTAL DERMATOLOGY

MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation

(2011) Yang Liu et al.   FEBS LETTERS

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

JC virus promoter/enhancers contain TATA box-associated Spi-B-binding sites that support early viral gene expression in primary astrocytes

(2011) L. J. Marshall et al.   JOURNAL OF GENERAL VIROLOGY

JC virus granule cell neuronopathy is associated with VP1 C terminus mutants

(2011) X. Dang et al.   JOURNAL OF GENERAL VIROLOGY

Quantifying Antigen-Specific CD4 T Cells during a Viral Infection: CD4 T Cell Responses Are Larger Than We Think

(2011) D. S. McDermott et al.   JOURNAL OF IMMUNOLOGY

Suppressive CD8+ T Cells Arise in the Absence of CD4 Help and Compromise Control of Persistent Virus

(2011) M. J. Molloy et al.   JOURNAL OF IMMUNOLOGY

Sequencing and Analysis of JC Virus DNA From Natalizumab-Treated PML Patients

(2011) Carl E. Reid et al.   JOURNAL OF INFECTIOUS DISEASES

Role of CD4+ and CD8+ T-Cell Responses against JC Virus in the Outcome of Patients with Progressive Multifocal Leukoencephalopathy (PML) and PML with Immune Reconstitution Inflammatory Syndrome

(2011) S. Gheuens et al.   JOURNAL OF VIROLOGY

Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS

(2011) M. C. Kowarik et al.   NEUROLOGY

Regulation of Human Neurotropic JC Virus Replication by Alternative Splicing Factor SF2/ASF in Glial Cells

(2011) Ilker Kudret Sariyer et al.   PLoS One

T Regulatory Cells Are Markers of Disease Activity in Multiple Sclerosis Patients

(2011) Dacia Dalla Libera et al.   PLoS One

Astrocytes modulate the chemokine network in a pathogen-specific manner

(2010) Clive S. McKimmie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure-Function Analysis of the Human JC Polyomavirus Establishes the LSTc Pentasaccharide as a Functional Receptor Motif

(2010) Ursula Neu et al.   Cell Host & Microbe

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activity

(2010) L. J. Marshall et al.   JOURNAL OF GENERAL VIROLOGY

The Curious Incident of the Dog in the Nighttime: Does the Absence of Virus Replication in Epstein‐Barr Virus–Transformed B Cells Point to an Important Feature of JC Virus Biology?

(2010) Sidney A. Houff et al.   JOURNAL OF INFECTIOUS DISEASES

Human Polyomavirus JC (JCV) Infection of Human B Lymphocytes: A Possible Mechanism for JCV Transmigration across the Blood‐Brain Barrier

(2010) Moti L. Chapagain et al.   JOURNAL OF INFECTIOUS DISEASES

JC Virus Latency in the Brain and Extraneural Organs of Patients with and without Progressive Multifocal Leukoencephalopathy

(2010) C. S. Tan et al.   JOURNAL OF VIROLOGY

Rearranged JC Virus Noncoding Control Regions Found in Progressive Multifocal Leukoencephalopathy Patient Samples Increase Virus Early Gene Expression and Replication Rate

(2010) Rainer Gosert et al.   JOURNAL OF VIROLOGY

Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

(2010) Chen S Tan et al.   LANCET NEUROLOGY

Differential regulation of TLR4 expression in human B cells and monocytes

(2010) Lisa M. Ganley-Leal et al.   MOLECULAR IMMUNOLOGY

CD4+T-bet+, CD4+pSTAT3+ and CD8+T-bet+ T cells accumulate in peripheral blood during NZB treatment

(2010) Giovanni Frisullo et al.   Multiple Sclerosis Journal

Progressive multifocal leukoencephalopathy and other forms of JC virus disease

(2010) Bruce J. Brew et al.   Nature Reviews Neurology

Disturbed regulatory T cell homeostasis in multiple sclerosis

(2010) Koen Venken et al.   TRENDS IN MOLECULAR MEDICINE

Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project

(2009) K. R. Carson et al.   BLOOD

The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkers

(2009) M. Khademi et al.   EUROPEAN JOURNAL OF NEUROLOGY

Virus-Encoded Homologs of Cellular Interleukin-10 and Their Control of Host Immune Function

(2009) B. Slobedman et al.   JOURNAL OF VIROLOGY

Regulation of Gene Expression in Primate Polyomaviruses

(2009) M. K. White et al.   JOURNAL OF VIROLOGY

Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid

(2009) J. Mellergård et al.   Multiple Sclerosis Journal

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells

(2009) P. Kivisakk et al.   NEUROLOGY

Asymptomatic Reactivation of JC Virus in Patients Treated with Natalizumab

(2009) Yiping Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML)

(2009) Shamil R. Sunyaev et al.   PLoS Genetics

Induction of systemic TNFα in Natalizumab-treated multiple sclerosis

(2008) M. Khademi et al.   EUROPEAN JOURNAL OF NEUROLOGY

Fumarates for the treatment of multiple sclerosis: potential mechanisms of action and clinical studies

(2008) Ralf A Linker et al.   Expert Review of Neurotherapeutics

Incidence, Clinical Presentation, and Outcome of Progressive Multifocal Leukoencephalopathy in HIV-Infected Patients during the Highly Active Antiretroviral Therapy Era: A Nationwide Cohort Study

(2008) Frederik Neess Engsig et al.   JOURNAL OF INFECTIOUS DISEASES

Glial connexins and gap junctions in CNS inflammation and disease

(2008) Tammy Kielian   JOURNAL OF NEUROCHEMISTRY

Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients

(2008) Raija L.P. Lindberg et al.   JOURNAL OF NEUROIMMUNOLOGY

Evolutionarily Conserved Function of a Viral MicroRNA

(2008) G. J. Seo et al.   JOURNAL OF VIROLOGY

Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis

(2008) M. Krumbholz et al.   NEUROLOGY

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

(2008) M. Mehling et al.   NEUROLOGY

Dimethylfumarate Reduces Leukocyte Rolling in Vivo through Modulation of Adhesion Molecule Expression

(2007) Simone A. Rubant et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

(2007) Jacques De Keyser et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES