Compositional Changes of B and T Cell Subtypes during Fingolimod Treatment in Multiple Sclerosis Patients: A 12-Month Follow-Up Study

Suppressed pro-inflammatory properties of circulating B cells in patients with multiple sclerosis treated with fingolimod, based on altered proportions of B-cell subpopulations

(2014) Yusei Miyazaki et al.   CLINICAL IMMUNOLOGY

Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis

(2014) Douglas Kazutoshi Sato et al.   JOURNAL OF NEUROIMMUNOLOGY

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

(2014) A. Palanichamy et al.   Science Translational Medicine

The unique features of follicular T cell subsets

(2013) Julie Tellier et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Which Immune Cells Matter? The Immunopathogenesis of Multiple Sclerosis

(2013) Bieke Broux et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

T cells that promote B-Cell maturation in systemic autoimmunity

(2012) Jason S. Weinstein et al.   IMMUNOLOGICAL REVIEWS

T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells

(2012) Michelle A. Linterman et al.   IMMUNOLOGICAL REVIEWS

Follicular helper T cells in immunity and systemic autoimmunity

(2012) Joseph E. Craft   Nature Reviews Rheumatology

Fingolimod for Multiple Sclerosis

(2012) Daniel Pelletier et al.   NEW ENGLAND JOURNAL OF MEDICINE

B cells in multiple sclerosis: connecting the dots

(2011) H-Christian von Büdingen et al.   CURRENT OPINION IN IMMUNOLOGY

Pharmacodynamic Effects of Steady-State Fingolimod on Antibody Response in Healthy Volunteers: A 4-Week, Randomized, Placebo-Controlled, Parallel-Group, Multiple-Dose Study

(2011) Craig Boulton et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS

(2011) M. C. Kowarik et al.   NEUROLOGY

Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis

(2011) M. Mehling et al.   NEUROLOGY

Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients

(2010) Matthias Mehling et al.   ANNALS OF NEUROLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

(2010) M. Mehling et al.   NEUROLOGY

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disturbed regulatory T cell homeostasis in multiple sclerosis

(2010) Koen Venken et al.   TRENDS IN MOLECULAR MEDICINE

B cell characterization and reactivity analysis in multiple sclerosis

(2009) J. Fraussen et al.   AUTOIMMUNITY REVIEWS

Immunomodulatory drug FTY720 induces regulatory CD4+CD25+T cellsin vitro

(2009) P. J. Zhou et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results

(2009) G. Comi et al.   Multiple Sclerosis Journal

Oral fingolimod (FTY720) in multiple sclerosis: Two-year results of a phase II extension study

(2009) P. O'Connor et al.   NEUROLOGY

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

(2008) M. Mehling et al.   NEUROLOGY

Compromised CD4+ CD25highregulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

(2007) Koen Venken et al.   IMMUNOLOGY