IL-10: A Multifunctional Cytokine in Viral Infections

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

(2017) Sarang Tartey et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Type I IFN signaling facilitates the development of IL-10-producing effector CD8+T cells during murine influenza virus infection

(2016) Li Jiang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential mucosal IL-10-induced immunoregulation of innate immune responses occurs in influenza infected infants/toddlers and adults

(2016) David Verhoeven et al.   IMMUNOLOGY AND CELL BIOLOGY

IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection

(2016) Yuan Tian et al.   JOURNAL OF IMMUNOLOGY

Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages

(2016) Ashleigh Howes et al.   JOURNAL OF IMMUNOLOGY

CCR5 ameliorates Japanese encephalitis via dictating the equilibrium of regulatory CD4+Foxp3+ T and IL-17+CD4+ Th17 cells

(2016) Jin Hyoung Kim et al.   Journal of Neuroinflammation

Exploitation of Interleukin-10 (IL-10) Signaling Pathways: Alternate Roles of Viral and Cellular IL-10 in Rhesus Cytomegalovirus Infection

(2016) Meghan K. Eberhardt et al.   JOURNAL OF VIROLOGY

Type I Interferons and NK Cells Restrict Gammaherpesvirus Lymph Node Infection

(2016) Clara Lawler et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus-Encoded Human Interleukin-10 (IL-10) Homolog Amplifies Its Immunomodulatory Potential by Upregulating Human IL-10 in Monocytes

(2016) Selmir Avdic et al.   JOURNAL OF VIROLOGY

Follicular dendritic cell disruption as a novel mechanism of virus-induced immunosuppression

(2016) Eleonora Melzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection

(2016) Laura M. Snell et al.   Cell Reports

Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread

(2016) Stephanie S. Cush et al.   PLoS Pathogens

Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus

(2016) Helen E. Farrell et al.   PLoS Pathogens

Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence

(2016) Mathew Clement et al.   PLoS Pathogens

Regulatory B10 cell development and function: Fig. 1.

(2015) Jacquelyn M. Lykken et al.   INTERNATIONAL IMMUNOLOGY

Suppressive functions of B cells in infectious diseases: Fig. 1.

(2015) Ping Shen et al.   INTERNATIONAL IMMUNOLOGY

Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells

(2015) Brian J Laidlaw et al.   NATURE IMMUNOLOGY

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

B10 cell regulation of health and disease

(2014) Kathleen M. Candando et al.   IMMUNOLOGICAL REVIEWS

IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration

(2014) Naoyuki Makita et al.   INTERNATIONAL IMMUNOLOGY

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1

(2014) Ian A. Parish et al.   JOURNAL OF CLINICAL INVESTIGATION

Mononuclear Phagocyte-Derived IL-10 Suppresses the Innate IL-12/IFN-  Axis in Lung-Challenged Aged Mice

(2014) B.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T Cells

(2014) M. Batten et al.   JOURNAL OF IMMUNOLOGY

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

(2014) V. Lampropoulou et al.   JOURNAL OF IMMUNOLOGY

Infiltrating Regulatory B Cells Control Neuroinflammation following Viral Brain Infection

(2014) Manohar B. Mutnal et al.   JOURNAL OF IMMUNOLOGY

Phenotype Alterations in Regulatory T-Cell Subsets in Primary HIV Infection and Identification of Tr1-like Cells as the Main Interleukin 10-Producing CD4+ T Cells

(2014) M. F. Chevalier et al.   JOURNAL OF INFECTIOUS DISEASES

IL-10-Producing B Cells Are Induced Early in HIV-1 Infection and Suppress HIV-1-Specific T Cell Responses

(2014) Jun Liu et al.   PLoS One

Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis

(2014) Kirsten A. Kulcsar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus

(2014) Mya Myat Ngwe Tun et al.   Scientific Reports

Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus

(2014) Selmir Avdic et al.   Frontiers in Microbiology

Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcγR or complement

(2013) Kirsten Richter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus Interleukin-10 Polarizes Monocytes toward a Deactivated M2c Phenotype To Repress Host Immune Responses

(2013) S. Avdic et al.   JOURNAL OF VIROLOGY

Viral Infection Increases Glucocorticoid-Induced Interleukin-10 Production through ERK-Mediated Phosphorylation of the Glucocorticoid Receptor in Dendritic Cells: Potential Clinical Implications

(2013) Sinnie Sin Man Ng et al.   PLoS One

Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection

(2013) Obinna Chijioke et al.   Cell Reports

Macrophage and T Cell Produced IL-10 Promotes Viral Chronicity

(2013) Kirsten Richter et al.   PLoS Pathogens

Human Cytomegalovirus Latency-Associated Proteins Elicit Immune-Suppressive IL-10 Producing CD4+ T Cells

(2013) Gavin M. Mason et al.   PLoS Pathogens

Regulation of Adaptive Immunity; The Role of Interleukin-10

(2013) T. H. Sky Ng et al.   Frontiers in Immunology

Epstein-Barr Virus IL-10 Engages IL-10R1 by a Two-step Mechanism Leading to Altered Signaling Properties

(2012) Sung Il Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-10-Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection

(2012) A. Das et al.   JOURNAL OF IMMUNOLOGY

PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

(2012) K. F. MacKenzie et al.   JOURNAL OF IMMUNOLOGY

Regulatory B Cell (B10 Cell) Expansion during Listeria Infection Governs Innate and Cellular Immune Responses in Mice

(2012) M. Horikawa et al.   JOURNAL OF IMMUNOLOGY

Inhibition of JAKs in Macrophages Increases Lipopolysaccharide-Induced Cytokine Production by Blocking IL-10-Mediated Feedback

(2012) M. J. Pattison et al.   JOURNAL OF IMMUNOLOGY

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

IL-10 Regulates Viral Lung Immunopathology during Acute Respiratory Syncytial Virus Infection in Mice

(2012) Jens Loebbermann et al.   PLoS One

IL-10 Mediated Regulation of Liver Inflammation during Acute Murine Cytomegalovirus Infection

(2012) Pamela J. Gaddi et al.   PLoS One

Infected CD8 - dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection

(2012) C. T. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Cytomegalovirus Encoded Homologs of Cytokines, Chemokines and their Receptors: Roles in Immunomodulation

(2012) Brian McSharry et al.   Viruses-Basel

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

(2012) Namiko Hoshi et al.   Nature Communications

The EBV Immunoevasins vIL-10 and BNLF2a Protect Newly Infected B Cells from Immune Recognition and Elimination

(2012) Simon Jochum et al.   PLoS Pathogens

Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cells

(2012) Masato Kubo et al.   Frontiers in Immunology

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Gregori S, Tomasoni D, Pacciani V, et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood. 2010;116(6):935-944.

(2011)   BLOOD

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

(2011) Ashutosh Chaudhry et al.   IMMUNITY

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

IL-27 Promotes IL-10 Production by Effector Th1 CD4+ T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection

(2011) A. P. Freitas do Rosario et al.   JOURNAL OF IMMUNOLOGY

IL-10 Restricts Activation-Induced Death of NK Cells during Acute Murine Cytomegalovirus Infection

(2011) M. A. Stacey et al.   JOURNAL OF IMMUNOLOGY

Highly Activated Cytotoxic CD8 T Cells Express Protective IL-10 at the Peak of Coronavirus-Induced Encephalitis

(2011) K. Trandem et al.   JOURNAL OF IMMUNOLOGY

Functional impairment of dendritic cells in patients infected with hepatitis C virus genotype 1 who failed peginterferon plus ribavirin therapy

(2011) Cheng-Chao Liang et al.   JOURNAL OF MEDICAL VIROLOGY

Shifting Hierarchies of Interleukin-10-Producing T Cell Populations in the Central Nervous System during Acute and Persistent Viral Encephalomyelitis

(2011) S. S. Puntambekar et al.   JOURNAL OF VIROLOGY

CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs

(2011) Jie Sun et al.   NATURE IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Type I IFN Promotes IL-10 Production from T Cells to Suppress Th17 Cells and Th17-Associated Autoimmune Inflammation

(2011) Lixia Zhang et al.   PLoS One

Viral Latency and Its Regulation: Lessons from the γ-Herpesviruses

(2010) Samuel H. Speck et al.   Cell Host & Microbe

Signaling via the MyD88 Adaptor Protein in B Cells Suppresses Protective Immunity during Salmonella typhimurium Infection

(2010) Patricia Neves et al.   IMMUNITY

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model

(2010) Sylvie Amu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLR1/2, TLR7, and TLR9 Signals Directly Activate Human Peripheral Blood Naive and Memory B Cell Subsets to Produce Cytokines, Chemokines, and Hematopoietic Growth Factors

(2010) Sudhanshu Agrawal et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection

(2010) Galit Alter et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR-2-Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells

(2010) A. Sayi et al.   JOURNAL OF IMMUNOLOGY

IL-10 Restricts Memory T Cell Inflation during Cytomegalovirus Infection

(2010) M. Jones et al.   JOURNAL OF IMMUNOLOGY

Early IL-10 predominant responses are associated with progression to chronic hepatitis C virus infection in injecting drug users

(2010) J. K. Flynn et al.   JOURNAL OF VIRAL HEPATITIS

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection

(2010) D. G. Brooks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFNγ-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment

(2010) Ellen M. Palmer et al.   VIROLOGY

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

(2009) M. A. Brockman et al.   BLOOD

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

(2009) Roberto Tinoco et al.   IMMUNITY

Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation

(2009) Craig L. Maynard et al.   IMMUNOLOGICAL REVIEWS

Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10–secreting Th1 cells

(2009) Leona Gabryšová et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection

(2009) Seung-Hwan Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation

(2009) R. Madan et al.   JOURNAL OF IMMUNOLOGY

Monocyte‐Derived Dendritic Cells from HIV Type 1–Infected Individuals Show Reduced Ability to Stimulate T Cells and Have Altered Production of Interleukin (IL)–12 and IL‐10

(2009) Sandrine Buisson et al.   JOURNAL OF INFECTIOUS DISEASES

Interleukin‐10 Promoter Polymorphisms Influence HIV‐1 Susceptibility and Primary HIV‐1 Pathogenesis

(2009) Dshanta D. Naicker et al.   JOURNAL OF INFECTIOUS DISEASES

IFN-α amplifies human naïve B cell TLR-9-mediated activation and Ig production

(2009) L. Giordani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Virus-Encoded Homologs of Cellular Interleukin-10 and Their Control of Host Immune Function

(2009) B. Slobedman et al.   JOURNAL OF VIROLOGY

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

Immunosuppression during Acute Infection with Foot-and-Mouth Disease Virus in Swine Is Mediated by IL-10

(2009) Fayna Díaz-San Segundo et al.   PLoS One

The role of CD40 and CD154/CD40L in dendritic cells

(2009) Daphne Y. Ma et al.   SEMINARS IN IMMUNOLOGY

Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells

(2008) L R Grant et al.   GENES AND IMMUNITY

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Posttranscriptional Regulation of Il10 Gene Expression Allows Natural Killer Cells to Express Immunoregulatory Function

(2008) Asher Maroof et al.   IMMUNITY

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

A captured viral interleukin 10 gene with cellular exon structure

(2008)   JOURNAL OF GENERAL VIROLOGY

Comparative methodologies of regulatory T cell depletion in a murine melanoma model

(2008) Norimasa Matsushita et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Hepatitis C Virus Inhibits Cell Surface Expression of HLA-DR, Prevents Dendritic Cell Maturation, and Induces Interleukin-10 Production

(2008) K. Saito et al.   JOURNAL OF VIROLOGY

Immunomodulatory Properties of a Viral Homolog of Human Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection

(2008) C. Jenkins et al.   JOURNAL OF VIROLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Stimulation of B lymphocytes by cmvIL-10 but not LAcmvIL-10

(2008) Juliet V. Spencer et al.   VIROLOGY