Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

Proteome-wide covalent ligand discovery in native biological systems

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Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

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FOXP3+ regulatory T cells and their functional regulation

(2015) Zhiyuan Li et al.   Cellular & Molecular Immunology

Risk of progressive multifocal leukoencephalopathy in patients with multiple sclerosis

(2015) Michele Faulkner   Expert Opinion On Drug Safety

Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein

(2015) Irida Kastrati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner

(2015) Geoffrey O. Gillard et al.   JOURNAL OF NEUROIMMUNOLOGY

ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity

(2015) T. Xu et al.   Journal of Proteomics

Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD)

(2014) P. K. Chakraborty et al.   BLOOD

IRF4 at the crossroads of effector T-cell fate decision

(2014) Magdalena Huber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE

(2014) Hui Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunosuppressive potential of bardoxolone methyl using a modified murine local lymph node assay (LLNA)

(2014) Mika Kitsukawa et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells

(2014) M. Giordano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimethyl Fumarate for Treatment of Multiple Sclerosis: Mechanism of Action, Effectiveness, and Side Effects

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Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

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A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

(2013) Chu Wang et al.   NATURE METHODS

Protein Kinase Cθ C2 Domain Is a Phosphotyrosine Binding Module That Plays a Key Role in Its Activation

(2012) Robert V. Stahelin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

(2012) Haiyan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PML promotes MHC class II gene expression by stabilizing the class II transactivator

(2012) Tobias Ulbricht et al.   JOURNAL OF CELL BIOLOGY

Effects of dimethyl fumarate on neuroprotection and immunomodulation

(2012) Philipp Albrecht et al.   Journal of Neuroinflammation

The “Poison Chair” Treatment for Multiple Sclerosis

(2012) Allan H. Ropper   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

(2012) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Anti-Inflammatory Effects of Dimethyl Fumarate in Astrocytes Involve Glutathione and Haem Oxygenase-1

(2011) Shao Xia Lin et al.   ASN Neuro

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

(2011) Kamran Ghoreschi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28

(2011) Kok-Fai Kong et al.   NATURE IMMUNOLOGY

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

(2011) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

(2010) S. Nagaraj et al.   CLINICAL CANCER RESEARCH

Immunomodulatory and therapeutic activity of curcumin

(2010) Raghvendra M. Srivastava et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements

(2008) Ya-Lin Chiu et al.   Annual Review of Immunology

The IRF Family Transcription Factors in Immunity and Oncogenesis

(2008) Tomohiko Tamura et al.   Annual Review of Immunology

Hepatitis B: modern concepts in pathogenesis ??? APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus

(2008) Marianne Bonvin et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Immunomodulatory Activity of Synthetic Triterpenoids: Inhibition of Lymphocyte Proliferation, Cell-Mediated Cytotoxicity, and Cytokine Gene Expression Through Suppression of NF-κB

(2008) Xiaohua Gao et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY