Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors

Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae

(2016) Yukiko Akahori et al.   BMC IMMUNOLOGY

Binding activities of non-β-glucan glycoclusters to dectin-1 and exploration of their binding site

(2016) Shan Jiang et al.   CARBOHYDRATE RESEARCH

Immune sensing of microbial glycolipids and related conjugates by T cells and the pattern recognition receptors MCL and Mincle

(2016) Dylan G.M. Smith et al.   CARBOHYDRATE RESEARCH

Total synthesis of a cyclopropane-fatty acid α-glucosyl diglyceride from Lactobacillus plantarum and identification of its ability to signal through Mincle

(2016) Sayali Shah et al.   CHEMICAL COMMUNICATIONS

IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease

(2016) Hao Zhou et al.   HEPATOLOGY

Antifungal Activity of Plasmacytoid Dendritic Cells against Cryptococcus neoformansIn VitroRequires Expression of Dectin-3 (CLEC4D) and Reactive Oxygen Species

(2016) Camaron R. Hole et al.   INFECTION AND IMMUNITY

Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro

(2016) Emmanuel C Patin et al.   Innate Immunity

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo

(2016) Alexandra Huber et al.   Innate Immunity

Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis

(2016) Fabio SY Yoshikawa et al.   Innate Immunity

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

(2016) Alexandra Wittmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle

(2016) Hadar Feinberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An atypical role for the myeloid receptor Mincle in central nervous system injury

(2016) Thiruma V Arumugam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor–mediated antifungal innate immunity

(2016) Le-Le Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity

(2016) Min Jung Lee et al.   JOURNAL OF IMMUNOLOGY

Mincle Signaling Promotes Con A Hepatitis

(2016) Stephanie H. Greco et al.   JOURNAL OF IMMUNOLOGY

Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye

(2016) Ellen J. Lee et al.   JOURNAL OF IMMUNOLOGY

Mincle suppresses Toll-like receptor 4 activation

(2016) Stephanie H. Greco et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation

(2016) Bernhard Kerscher et al.   MICROBES AND INFECTION

Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis

(2016) T Zelante et al.   Mucosal Immunology

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Targeting CBLB as a potential therapeutic approach for disseminated candidiasis

(2016) Yun Xiao et al.   NATURE MEDICINE

Inhibition of CBLB protects from lethal Candida albicans sepsis

(2016) Gerald Wirnsberger et al.   NATURE MEDICINE

Integration of Innate Immune Signaling

(2016) Christoph A. Thaiss et al.   TRENDS IN IMMUNOLOGY

Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

(2016) Wook-Bin Lee et al.   Nature Communications

Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut

(2016) Tingting Wang et al.   PLoS Pathogens

The C-Type Lectin Receptor CLECSF8/CLEC4D Is a Key Component of Anti-Mycobacterial Immunity

(2015) Gillian J. Wilson et al.   Cell Host & Microbe

The Uptake of Trehalose Glycolipids by Macrophages Is Independent of Mincle

(2015) Kristel Kodar et al.   CHEMBIOCHEM

Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: total synthesis and structure activity relationships

(2015) Mark B. Richardson et al.   CHEMICAL COMMUNICATIONS

Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

(2015) Phillip L. van der Peet et al.   CHEMICAL COMMUNICATIONS

C-type lectins in immunity: recent developments

(2015) Ivy M Dambuza et al.   CURRENT OPINION IN IMMUNOLOGY

Recent insights into structures and functions of C-type lectins in the immune system

(2015) Kurt Drickamer et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge

(2015) Bernhard Kerscher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition

(2015) Marcel Wüthrich et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation

(2015) Zhifang Cao et al.   IMMUNITY

The C-Type Lectin Receptor MCL Mediates Vaccine-Induced Immunity against Infection with Blastomyces dermatitidis

(2015) Huafeng Wang et al.   INFECTION AND IMMUNITY

A critical role of Dectin-1 in hypersensitivity pneumonitis

(2015) Mari Higashino-Kameda et al.   INFLAMMATION RESEARCH

Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells

(2015) Sébastien Lemoine et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses

(2015) Ryoko Kiyotake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of MINCLE–SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB

(2015) Jenny Ostrop et al.   JOURNAL OF IMMUNOLOGY

C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation

(2015) Yasunobu Miyake et al.   JOURNAL OF IMMUNOLOGY

Mincle Signaling in the Innate Immune Response after Traumatic Brain Injury

(2015) Juan Carlos de Rivero Vaccari et al.   JOURNAL OF NEUROTRAUMA

Mouse Mincle: Characterization as a Model for Human Mincle and Evolutionary Implications

(2015) Neela Rambaruth et al.   MOLECULES

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses

(2015) Zihou Deng et al.   NATURE IMMUNOLOGY

The natural product brartemicin is a high affinity ligand for the carbohydrate-recognition domain of the macrophage receptor mincle

(2015) Kristian M. Jacobsen et al.   MedChemComm

Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy

(2015) Savita Devi et al.   Scientific Reports

Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways

(2015) Lena Seifert et al.   Cell Reports

Recognition of Aspergillus fumigatus Hyphae by Human Plasmacytoid Dendritic Cells Is Mediated by Dectin-2 and Results in Formation of Extracellular Traps

(2015) Flávio V. Loures et al.   PLoS Pathogens

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway

(2015) Juin-Hua Huang et al.   PLoS Pathogens

The C-Type Lectin Receptor Mincle Binds to Streptococcus pneumoniae but Plays a Limited Role in the Anti-Pneumococcal Innate Immune Response

(2015) Anne Rabes et al.   PLoS One

Fungal Engagement of the C-Type Lectin Mincle Suppresses Dectin-1-Induced Antifungal Immunity

(2014) Brigitte A. Wevers et al.   Cell Host & Microbe

On One Leg: Trehalose Monoesters Activate Macrophages in a Mincle-Dependent Manner

(2014) Bridget L. Stocker et al.   CHEMBIOCHEM

Interleukin 17–Producing γδT Cells Promote Hepatic Regeneration in Mice

(2014) Raghavendra Rao et al.   GASTROENTEROLOGY

Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate

(2014) Sabine A F Jégouzo et al.   GLYCOBIOLOGY

Differential regulation of oxidative burst by distinct β-glucan-binding receptors and signaling pathways in human peripheral blood mononuclear cells

(2014) Nandita Bose et al.   GLYCOBIOLOGY

Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria

(2014) Akiko Yonekawa et al.   IMMUNITY

Macrophage-Inducible C-Type Lectin Mincle-Expressing Dendritic Cells Contribute to Control of Splenic Mycobacterium bovis BCG Infection in Mice

(2014) Friederike Behler et al.   INFECTION AND IMMUNITY

Dectin-2 Deficiency Promotes Th2 Response and Mucin Production in the Lungs after Pulmonary Infection with Cryptococcus neoformans

(2014) Yuri Nakamura et al.   INFECTION AND IMMUNITY

C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6′-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-κB Activation

(2014) Xue-Qiang Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycerol Monomycolate Is a Novel Ligand for the Human, but Not Mouse Macrophage Inducible C-type Lectin, Mincle

(2014) Yuki Hattori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity

(2014) Xin-Ming Jia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

(2014) C. A. Wells et al.   JOURNAL OF IMMUNOLOGY

Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells

(2014) H. S. Goodridge et al.   JOURNAL OF IMMUNOLOGY

Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells

(2014) N. A. Barrett et al.   JOURNAL OF IMMUNOLOGY

C-Type Lectin Receptors Differentially Induce Th17 Cells and Vaccine Immunity to the Endemic Mycosis of North America

(2014) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Dectin-1 Pathway Activates Robust Autophagy-Dependent Unconventional Protein Secretion in Human Macrophages

(2014) T. Ohman et al.   JOURNAL OF IMMUNOLOGY

Differential Control of Mincle-Dependent Cord Factor Recognition and Macrophage Responses by the Transcription Factors C/EBPβ and HIF1α

(2014) Hanne Schoenen et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen,Candida albicans

(2014) Sandhya Ganesan et al.   JOURNAL OF IMMUNOLOGY

The WNT Signaling Pathway Contributes to Dectin-1-Dependent Inhibition of Toll-Like Receptor-Induced Inflammatory Signature

(2014) J. Trinath et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of the Receptors for Mycobacterial Cord Factor in Guinea Pig

(2014) Kenji Toyonaga et al.   PLoS One

Interleukin-1 and Interferon-γ Orchestrate β-Glucan-Activated Human Dendritic Cell Programming via IκB-ζ Modulation

(2014) Marco Cardone et al.   PLoS One

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

(2014) Jaap T. van Dissel et al.   VACCINE

Dectin-1 Is Expressed in Human Lung and Mediates the Proinflammatory Immune Response to Nontypeable Haemophilus influenzae

(2014) K. A. Heyl et al.   mBio

The Non-receptor Tyrosine Kinase Tec Controls Assembly and Activity of the Noncanonical Caspase-8 Inflammasome

(2014) Florian Zwolanek et al.   PLoS Pathogens

MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns

(2014) Mark B. Richardson et al.   Frontiers in Immunology

Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau

(2013) Victor Raúl Gómez Román et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Trehalose diesters, lipoteichoic acids and α-GalCer: using chemistry to understand immunology

(2013) Bridget L. Stocker et al.   CARBOHYDRATE RESEARCH

Vimentin is an endogenous ligand for the pattern recognition receptor Dectin-1

(2013) Praveena S. Thiagarajan et al.   CARDIOVASCULAR RESEARCH

Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic Fungus Malassezia

(2013) Tetsuaki Ishikawa et al.   Cell Host & Microbe

Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ

(2013) Ana Lobato-Pascual et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Signaling while eating: MCL is coupled with Mincle

(2013) Sho Yamasaki   EUROPEAN JOURNAL OF IMMUNOLOGY

C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection

(2013) Le-Le Zhu et al.   IMMUNITY

C-type Lectin MCL Is an FcRγ-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor

(2013) Yasunobu Miyake et al.   IMMUNITY

Interferon-β Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells Is Crucial for Immunity to C. albicans

(2013) Carlos del Fresno et al.   IMMUNITY

Neither Dectin-2 nor the Mannose Receptor Is Required for Resistance to Coccidioides immitis in Mice

(2013) Suganya Viriyakosol et al.   INFECTION AND IMMUNITY

Role of Dectin-2 for Host Defense against Systemic Infection with Candida glabrata

(2013) Daniela C. Ifrim et al.   INFECTION AND IMMUNITY

The Dectin-2 family of C-type lectin-like receptors: an update

(2013) Bernhard Kerscher et al.   INTERNATIONAL IMMUNOLOGY

C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways

(2013) Anthony Plato et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle

(2013) Hadar Feinberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Candida albicans Primes TLR Cytokine Responses through a Dectin-1/Raf-1-Mediated Pathway

(2013) D. C. Ifrim et al.   JOURNAL OF IMMUNOLOGY

Comparative Analysis of Monocyte Subsets in the Pig

(2013) L. Fairbairn et al.   JOURNAL OF IMMUNOLOGY

Protective Role of Mincle in Bacterial Pneumonia by Regulation of Neutrophil Mediated Phagocytosis and Extracellular Trap Formation

(2013) A. Sharma et al.   JOURNAL OF INFECTIOUS DISEASES

C-type lectin receptor Clec4d plays a protective role in resolution of Gram-negative pneumonia

(2013) Anthony L. Steichen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers

(2013) Suzanne E. Elcombe et al.   PLoS One

The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling

(2013) Christiane Desel et al.   PLoS One

Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL

(2013) A. Furukawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation

(2013) Susanne Roth et al.   TRENDS IN IMMUNOLOGY

Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke

(2013) Yukiya Suzuki et al.   Scientific Reports

LAB/NTAL Facilitates Fungal/PAMP-induced IL-12 and IFN-γ Production by Repressing β-Catenin Activation in Dendritic Cells

(2013) Selinda J. Orr et al.   PLoS Pathogens

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

Signaling through Toll-like receptor 3 and Dectin-1 potentiates the capability of human monocyte-derived dendritic cells to promote T-helper 1 and T-helper 17 immune responses

(2012) Ana Dragicevic et al.   CYTOTHERAPY

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity

(2012) Dominikus Strasser et al.   IMMUNITY

The mycobacterial cord factor adjuvant analogue trehalose-6,6′-dibehenate (TDB) activates the Nlrp3 inflammasome

(2012) Katrin Schweneker et al.   IMMUNOBIOLOGY

Mincle is not essential for controlling Mycobacterium tuberculosis infection

(2012) Lisa Heitmann et al.   IMMUNOBIOLOGY

Mincle polarizes human monocyte and neutrophil responses to Candida albicans

(2012) Dipti Vijayan et al.   IMMUNOLOGY AND CELL BIOLOGY

Dectin-1-triggered Recruitment of Light Chain 3 Protein to Phagosomes Facilitates Major Histocompatibility Complex Class II Presentation of Fungal-derived Antigens

(2012) Jun Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase

(2012) Lisa M. Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dectin-1 Stimulation Induces Suppressor of Cytokine Signaling 1, Thereby Modulating TLR Signaling and T Cell Responses

(2012) M. E. Eberle et al.   JOURNAL OF IMMUNOLOGY

Role of Mincle in Alveolar Macrophage-Dependent Innate Immunity against Mycobacterial Infections in Mice

(2012) F. Behler et al.   JOURNAL OF IMMUNOLOGY

Synergism between Curdlan and GM-CSF Confers a Strong Inflammatory Signature to Dendritic Cells

(2012) L. Min et al.   JOURNAL OF IMMUNOLOGY

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

(2012) I. D. Iliev et al.   SCIENCE

Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway

(2012) Wook-Bin Lee et al.   PLoS Pathogens

Restoration of Pattern Recognition Receptor Costimulation to Treat Chromoblastomycosis, a Chronic Fungal Infection of the Skin

(2011) Maria da Glória Sousa et al.   Cell Host & Microbe

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Long-Chain Lipids Are Required for the Innate Immune Recognition of Trehalose Diesters by Macrophages

(2011) Ashna A. Khan et al.   CHEMBIOCHEM

Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: Findings, implications and open questions

(2011) Roland Lang et al.   IMMUNOBIOLOGY

Lectin Site Ligation of CR3 Induces Conformational Changes and Signaling

(2011) Xian M. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase Cγ2 (PLCγ2) Is Key Component in Dectin-2 Signaling Pathway, Mediating Anti-fungal Innate Immune Responses

(2011) Sara Gorjestani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase Cδ is a critical component of Dectin-1 signaling in primary human monocytes

(2011) Deena H. Elsori et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2

(2011) Sonja I. Gringhuis et al.   PLoS Pathogens

Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins

(2010) Lu Wang et al.   IMMUNITY

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

CARD9 Mediates Dectin-2-induced IκBα Kinase Ubiquitination Leading to Activation of NF-κB in Response to Stimulation by the Hyphal Form ofCandida albicans

(2010) Liangkuan Bi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The adaptor molecule CARD9 is essential for tuberculosis control

(2010) Anca Dorhoi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

(1,3)- -Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

(2010) P. Kankkunen et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1

(2010) F. L. van de Veerdonk et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

(2010) M. Ritter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pattern recognition: recent insights from Dectin-1

(2009) Delyth M Reid et al.   CURRENT OPINION IN IMMUNOLOGY

Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways

(2009) Kevin M. Dennehy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

Phospholipase Cγ2 Is Critical for Dectin-1-mediated Ca2+Flux and Cytokine Production in Dendritic Cells

(2009) Shengli Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

(2009) Matthew J. Robinson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation

(2009) Kerstin Werninghaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requisite Role for the Dectin-1  -Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus

(2009) J. L. Werner et al.   JOURNAL OF IMMUNOLOGY

Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for β-glucan-bearing particles

(2009) Robin van Bruggen et al.   MOLECULAR IMMUNOLOGY

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

C-type lectin Mincle is an activating receptor for pathogenic fungus,Malassezia

(2009) Sho Yamasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissociation of Toll-Like Receptor 2-Mediated Innate Immune Response to Zymosan by Organic Solvent-Treatment without Loss of Dectin-1 Reactivity

(2008) Yoshihiko Ikeda et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Mycobacterium abscessusactivates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1

(2008) Dong-Min Shin et al.   CELLULAR MICROBIOLOGY

Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages

(2008) Gerben Ferwerda et al.   CELLULAR MICROBIOLOGY

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

(2008) Kevin M. Dennehy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans

(2008) A. Bugarcic et al.   GLYCOBIOLOGY

Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells

(2008) Franca Gerosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei

(2008) K NAKAMURA et al.   MICROBES AND INFECTION

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY

Cationic Liposomes Formulated with Synthetic Mycobacterial Cordfactor (CAF01): A Versatile Adjuvant for Vaccines with Different Immunological Requirements

(2008) Else Marie Agger et al.   PLoS One