Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization

Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation

(2016) Haoting Hsu et al.   JOURNAL OF IMMUNOLOGY

Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells

(2015) Sébastien Lemoine et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Contribution of MINCLE–SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB

(2015) Jenny Ostrop et al.   JOURNAL OF IMMUNOLOGY

Fungal Engagement of the C-Type Lectin Mincle Suppresses Dectin-1-Induced Antifungal Immunity

(2014) Brigitte A. Wevers et al.   Cell Host & Microbe

Improved pertussis vaccines based on adjuvants that induce cell-mediated immunity

(2014) Aideen C Allen et al.   Expert Review of Vaccines

Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis

(2014) Esmaeil Mortaz et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Heterologous Immunological Effects of Early BCG Vaccination in Low-Birth-Weight Infants in Guinea-Bissau: A Randomized-controlled Trial

(2014) Kristoffer Jarlov Jensen et al.   JOURNAL OF INFECTIOUS DISEASES

GLA-AF, an Emulsion-Free Vaccine Adjuvant for Pandemic Influenza

(2014) Christopher H. Clegg et al.   PLoS One

Soluble Mediators Regulating Immunity in Early Life

(2014) Matthew Aaron Pettengill et al.   Frontiers in Immunology

Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle

(2013) Hadar Feinberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection

(2013) Shokrollah Elahi et al.   NATURE

The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes

(2013) David J. Dowling et al.   PLoS One

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation

(2013) Jesse W. Williams et al.   Nature Communications

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

(2012) Lara M Kingeter et al.   Cellular & Molecular Immunology

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity

(2012) Dominikus Strasser et al.   IMMUNITY

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

Mincle polarizes human monocyte and neutrophil responses to Candida albicans

(2012) Dipti Vijayan et al.   IMMUNOLOGY AND CELL BIOLOGY

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways

(2012) Victoria J. Philbin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dectin-1 Stimulation Induces Suppressor of Cytokine Signaling 1, Thereby Modulating TLR Signaling and T Cell Responses

(2012) M. E. Eberle et al.   JOURNAL OF IMMUNOLOGY

Synchronization of Dendritic Cell Activation and Antigen Exposure Is Required for the Induction of Th1/Th17 Responses

(2012) A. T. Kamath et al.   JOURNAL OF IMMUNOLOGY

Neonatal Plasma Polarizes TLR4-Mediated Cytokine Responses towards Low IL-12p70 and High IL-10 Production via Distinct Factors

(2012) Mirjam E. Belderbos et al.   PLoS One

Immunogenicity and Protective Capacity of a Virosomal Respiratory Syncytial Virus Vaccine Adjuvanted with Monophosphoryl Lipid A in Mice

(2012) Tobias Kamphuis et al.   PLoS One

Immunization of newborns with bacterial conjugate vaccines

(2012) Anita H.J. van den Biggelaar et al.   VACCINE

Immune response to vaccine adjuvants during the first year of life

(2012) Ofer Levy et al.   VACCINE

CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice

(2011) Jon Hansen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: Findings, implications and open questions

(2011) Roland Lang et al.   IMMUNOBIOLOGY

Interactions between TLR2, TLR4, and mannose receptors with gp43 fromParacoccidioides brasiliensisinduce cytokine production by human monocytes

(2011) Erika Nakaira-Takahagi et al.   MEDICAL MYCOLOGY

Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

(2011) Rhea N. Coler et al.   PLoS One

Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants

(2011) Sarah Burl et al.   PLoS One

Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction

(2011) Dmitri Smirnov et al.   VACCINE

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-146: Tiny Player in Neonatal Innate Immunity

(2010) Hans Lederhuber et al.   Neonatology

Innate immune mechanisms for recognition and uptake of Candida species

(2010) Mihai G. Netea et al.   TRENDS IN IMMUNOLOGY

Phenotype and function of neonatal DC

(2009) Fabienne Willems et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparable studies of immunostimulating activitiesin vitroamongMycobacterium bovisbacillus Calmette-Guérin (BCG) substrains

(2009) Daisuke Hayashi et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Mincle is a long sought receptor for mycobacterial cord factor

(2009) Isamu Matsunaga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

(2009) T. R. Kollmann et al.   JOURNAL OF IMMUNOLOGY

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

A Liposome-Based Mycobacterial Vaccine Induces Potent Adult and Neonatal Multifunctional T Cells through the Exquisite Targeting of Dendritic Cells

(2009) Arun T. Kamath et al.   PLoS One

Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells

(2009) Habib Zaghouani et al.   TRENDS IN IMMUNOLOGY

Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages

(2008) Gerben Ferwerda et al.   CELLULAR MICROBIOLOGY

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

(2008) Kevin M. Dennehy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

AS04-adjuvanted human papillomavirus-16/18 vaccination: recent advances in cervical cancer prevention

(2008) Tino F Schwarz   Expert Review of Vaccines

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY