Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse

Granulomatous responses in larval taeniid infections

(2018) Á. Díaz et al.   PARASITE IMMUNOLOGY

Schistosome-Induced Fibrotic Disease: The Role of Hepatic Stellate Cells

(2018) Jack P. Carson et al.   TRENDS IN PARASITOLOGY

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia

(2018) Joseph D. Turner et al.   PLoS Pathogens

Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection

(2018) Sharon M Campbell et al.   eLife

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33

(2017) Megan Osbourn et al.   IMMUNITY

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

(2017) Nicola L. Harris et al.   IMMUNITY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human schistosomiasis in the post mass drug administration era

(2017) Francisca Mutapi et al.   LANCET INFECTIOUS DISEASES

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

(2017) Carlos M. Minutti et al.   SCIENCE

Tissue-specific contribution of macrophages to wound healing

(2017) Carlos M. Minutti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Can Parasitic Worms Cure the Modern World’s Ills?

(2017) Margaret M. Harnett et al.   TRENDS IN PARASITOLOGY

Worm Control in Livestock: Bringing Science to the Field

(2017) Fiona Kenyon et al.   TRENDS IN PARASITOLOGY

Exploiting Helminth–Host Interactomes through Big Data

(2017) Javier Sotillo et al.   TRENDS IN PARASITOLOGY

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

(2017) Chris J. C. Johnston et al.   Nature Communications

Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis

(2017) Cesar Terrazas et al.   Scientific Reports

The Mannose Receptor in Regulation of Helminth-Mediated Host Immunity

(2017) Irma van Die et al.   Frontiers in Immunology

Fasciola hepatica Immune Regulates CD11c+ Cells by Interacting with the Macrophage Gal/GalNAc Lectin

(2017) Ernesto Rodríguez et al.   Frontiers in Immunology

Fasciola hepaticategumental antigens induce anergic-like T cells via dendritic cells in a mannose receptor-dependent manner

(2016) Allison Aldridge et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha

(2016) Lucy H. Jackson-Jones et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Comparison of RELMα and RELMβ Single- and Double-Gene-Deficient Mice Reveals that RELMα Expression Dictates Inflammation and Worm Expulsion in Hookworm Infection

(2016) Gang Chen et al.   INFECTION AND IMMUNITY

Regulation of the host immune system by helminth parasites

(2016) Rick M. Maizels et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD301b+ Macrophages Are Essential for Effective Skin Wound Healing

(2016) Brett Shook et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Construction of In Vivo Fluorescent Imaging of Echinococcus granulosus in a Mouse Model

(2016) Sibo Wang et al.   KOREAN JOURNAL OF PARASITOLOGY

Acidic chitinase primes the protective immune response to gastrointestinal nematodes

(2016) Kevin M Vannella et al.   NATURE IMMUNOLOGY

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

The geographical distribution and prevalence of Echinococcus multilocularis in animals in the European Union and adjacent countries: a systematic review and meta-analysis

(2016) Antti Oksanen et al.   Parasites & Vectors

Helminth infection promotes colonization resistance via type 2 immunity

(2016) Deepshika Ramanan et al.   SCIENCE

RELMs in the Realm of Helminths

(2016) William G.C. Horsnell et al.   TRENDS IN PARASITOLOGY

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

(2016) Calum C. Bain et al.   Nature Communications

PD-L2 negatively regulates Th1-mediated immunopathology during Fasciola hepatica infection

(2016) Cinthia C. Stempin et al.   Oncotarget

Tissue-Resident CD169 + Macrophages Form a Crucial Front Line against Plasmodium Infection

(2016) Pravesh Gupta et al.   Cell Reports

Surfactant Protein-D Is Essential for Immunity to Helminth Infection

(2016) Sumaiyya Thawer et al.   PLoS Pathogens

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

(2015) Abdullah A. Tarique et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Macrophages are required for host survival in experimental urogenital schistosomiasis

(2015) Chi-Ling Fu et al.   FASEB JOURNAL

Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

(2015) Camille Blériot et al.   IMMUNITY

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

(2015) Johanna A. Knipper et al.   IMMUNITY

Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis

(2015) L A Borthwick et al.   Mucosal Immunology

Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair

(2015) Julia Esser-von Bieren et al.   PLoS Pathogens

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

(2014) U. M. Gundra et al.   BLOOD

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Macrophage proliferation, provenance, and plasticity in macroparasite infection

(2014) Dominik Rückerl et al.   IMMUNOLOGICAL REVIEWS

CX3CR1+mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

(2014) Randy S. Longman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-4R  Expression by Bone Marrow-Derived Cells Is Necessary and Sufficient for Host Protection against Acute Schistosomiasis

(2014) D. R. Herbert et al.   JOURNAL OF IMMUNOLOGY

IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes

(2014) N. E. Humphreys et al.   JOURNAL OF IMMUNOLOGY

Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fcγ Receptor I

(2014) Julia Esser-von Bieren et al.   JOURNAL OF IMMUNOLOGY

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

Helminth therapy or elimination: epidemiological, immunological, and clinical considerations

(2014) Linda J Wammes et al.   LANCET INFECTIOUS DISEASES

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

(2014) Tara E Sutherland et al.   NATURE IMMUNOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Global numbers of infection and disease burden of soil transmitted helminth infections in 2010

(2014) Rachel L Pullan et al.   Parasites & Vectors

Helminth infection reactivates latent  -herpesvirus via cytokine competition at a viral promoter

(2014) T. A. Reese et al.   SCIENCE

Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

(2014) Kevin M. Vannella et al.   PLoS Pathogens

Ly6Chi Monocyte Recruitment Is Responsible for Th2 Associated Host-Protective Macrophage Accumulation in Liver Inflammation due to Schistosomiasis

(2014) Marcia Nascimento et al.   PLoS Pathogens

Ly6Chigh Monocytes Become Alternatively Activated Macrophages in Schistosome Granulomas with Help from CD4+ Cells

(2014) Natasha M. Girgis et al.   PLoS Pathogens

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

(2013) Steven J. Van Dyken et al.   Annual Review of Immunology

Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin

(2013) Marie Jaguin et al.   CELLULAR IMMUNOLOGY

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

(2013) Tamar Mchedlidze et al.   IMMUNITY

CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity

(2013) Yosuke Kumamoto et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

(2013) Stephen J. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

(2013) Luke Barron et al.   PLoS One

Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages

(2013) Julia Esser-von Bieren et al.   PLoS Pathogens

Sex-Associated Expression of Co-Stimulatory Molecules CD80, CD86, and Accessory Molecules, PDL-1, PDL-2 and MHC-II, in F480+ Macrophages during Murine Cysticercosis

(2013) Cristián Togno-Peirce et al.   Biomed Research International

The Schistosoma Granuloma: Friend or Foe?

(2013) Emily Hams et al.   Frontiers in Immunology

Induction of IL-4R -dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo

(2012) D. Ruckerl et al.   BLOOD

The biology of nematode- and IL4R -dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics

(2012) G. D. Thomas et al.   BLOOD

Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor

(2012) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection

(2012) Fei Chen et al.   NATURE MEDICINE

High-Resolution Transcriptome of Human Macrophages

(2012) Marc Beyer et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus

(2012) Lisa A. Reynolds et al.   Seminars in Immunopathology

Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury

(2011) Chun Geun Lee et al.   Annual Review of Physiology

Macrophage activation governs schistosomiasis-induced inflammation and fibrosis

(2011) Luke Barron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production

(2011) Ross A. Paveley et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2

(2010) S. Huber et al.   BLOOD

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Genes associated with alternatively activated macrophages discretely regulate helminth infection and pathogenesis in experimental mouse models

(2010) William G.C. Horsnell et al.   IMMUNOBIOLOGY

Early removal of alternatively activated macrophages leads to Taenia crassiceps cysticercosis clearance in vivo

(2010) José L. Reyes et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Arginase I Suppresses IL-12/IL-23p40-Driven Intestinal Inflammation during Acute Schistosomiasis

(2010) D. R. Herbert et al.   JOURNAL OF IMMUNOLOGY

STAT6−/− mice exhibit decreased cells with alternatively activated macrophage phenotypes and enhanced disease severity in murine neurocysticercosis

(2010) Bibhuti B. Mishra et al.   JOURNAL OF NEUROIMMUNOLOGY

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

Mesocestoides corti intracranial infection as a murine model for neurocysticercosis

(2010) JORGE I. ALVAREZ et al.   PARASITOLOGY

Heligmosomoides bakeri: a new name for an old worm?

(2010) Jerzy Behnke et al.   TRENDS IN PARASITOLOGY

IL-4Rα-Independent Expression of Mannose Receptor and Ym1 by Macrophages Depends on their IL-10 Responsiveness

(2010) Benjamin G. Dewals et al.   PLoS Neglected Tropical Diseases

Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

(2009) Meera G. Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Omega-1, a glycoprotein secreted bySchistosoma mansonieggs, drives Th2 responses

(2009) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

(2009) Svenja Steinfelder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing

(2009) K. J. Mylonas et al.   JOURNAL OF IMMUNOLOGY

IL-4−/−mice with lethalMesocestoides cortiinfections - reduced Th2 cytokines and alternatively activated macrophages

(2009) A. E. O’CONNELL et al.   PARASITE IMMUNOLOGY

Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity

(2009) John T. Pesce et al.   PLoS Pathogens

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

The Complex Role of Pro- and Anti-Inflammatory Cytokines in Cysticercosis:Immunological Lessons from Experimental and Natural Hosts

(2008) Luis Terrazas   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages

(2008) Benjamin J. Marsland et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Th2 Cytokine-Induced Alterations in Intestinal Smooth Muscle Function Depend on Alternatively Activated Macrophages

(2008) Aiping Zhao et al.   GASTROENTEROLOGY

The mannose receptor bindsTrichuris murisexcretory/secretory proteins but is not essential for protective immunity

(2008) Matthew L. deSchoolmeester et al.   IMMUNOLOGY

Interleukin-4-Promoted T Helper 2 Responses Enhance Nippostrongylus brasiliensis-Induced Pulmonary Pathology

(2008) H. Mearns et al.   INFECTION AND IMMUNITY

Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung

(2008) J. J. Reece et al.   INFECTION AND IMMUNITY

Dynamics of lung macrophage activation in response to helminth infection

(2008) Mark C. Siracusa et al.   JOURNAL OF LEUKOCYTE BIOLOGY