The Mannose Receptor in Regulation of Helminth-Mediated Host Immunity

The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells

(2017) Lisa C. Laan et al.   FASEB JOURNAL

Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils

(2017) Susan M van den Berg et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

High molecular weight components containing N -linked oligosaccharides of Ascaris suum extract inhibit the dendritic cells activation through DC-SIGN and MR

(2017) Bruna C. Favoretto et al.   MOLECULAR IMMUNOLOGY

Fasciola hepaticategumental antigens induce anergic-like T cells via dendritic cells in a mannose receptor-dependent manner

(2016) Allison Aldridge et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling

(2016) Marten A. Hoeksema et al.   FASEB JOURNAL

The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism

(2016) Emily Hams et al.   FASEB JOURNAL

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

(2016) S. Navarro et al.   Science Translational Medicine

Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor

(2016) Alessandra Ravidà et al.   PLoS Neglected Tropical Diseases

Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells

(2015) E J Klaver et al.   GENES AND IMMUNITY

Clinical trials of helminth therapy in autoimmune diseases: rationale and findings

(2015) J. O. Fleming et al.   PARASITE IMMUNOLOGY

Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis

(2015) Gijs Kooij et al.   Acta Neuropathologica Communications

Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor

(2015) Elsenoor J. Klaver et al.   PLoS One

Human macrophage polarization in vitro: Maturation and activation methods compared

(2014) Daphne Y.S. Vogel et al.   IMMUNOBIOLOGY

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

(2014) Maria E. Lund et al.   PLoS One

Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production

(2014) Sonja I. Gringhuis et al.   Nature Communications

Priming Dendritic Cells for Th2 Polarization: Lessons Learned from Helminths and Implications for Metabolic Disorders

(2014) Leonie Hussaarts et al.   Frontiers in Immunology

Reprogramming macrophages to an anti-inflammatory phenotype by helminth antigens reduces murine atherosclerosis

(2013) Ine M. J. Wolfs et al.   FASEB JOURNAL

Helminth therapy and multiple sclerosis

(2013) J.O. Fleming   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Fasciola hepaticategumental coat antigen suppresses MAPK signalling in dendritic cells and up-regulates the expression of SOCS3

(2013) K. V. Vukman et al.   PARASITE IMMUNOLOGY

Immunomodulatory molecules of Fasciola hepatica: Candidates for both vaccine and immunotherapeutic development

(2013) John P. Dalton et al.   VETERINARY PARASITOLOGY

Polarization of host immune responses by helminth-expressed glycans

(2012) Smanla Tundup et al.   Annals of the New York Academy of Sciences

Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated

(2012) Elsenoor J. Klaver et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor

(2012) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The mannose receptor

(2012) Luisa Martinez-Pomares   JOURNAL OF LEUKOCYTE BIOLOGY

Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation

(2012) Loes M. Kuijk et al.   MOLECULAR IMMUNOLOGY

The classical CD14++CD16− monocytes, but not the patrolling CD14+CD16+ monocytes, promote Th17 responses to Candida albicans

(2011) Sanne P. Smeekens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells

(2011) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Schistosoma mansoni egg glycoproteins and C-type lectins of host immune cells: Molecular partners that shape immune responses

(2011) Moniek H.J. Meevissen et al.   EXPERIMENTAL PARASITOLOGY

C-type lectins on macrophages participate in the immunomodulatory response to Fasciola hepatica products

(2011) Lorena Guasconi et al.   IMMUNOLOGY

The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production

(2011) Ross A. Paveley et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities

(2010) R. T. Lee et al.   GLYCOBIOLOGY

Worms to the rescue: Can worm glycans protect from autoimmune diseases?

(2010) Loes M. Kuijk et al.   IUBMB LIFE

Immune Modulation bySchistosoma mansoniAntigens in NOD Mice: Effects on Both Innate and Adaptive Immune Systems

(2010) Paola Zaccone et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Detailed N-glycan analysis of mannose receptor purified from murine spleen indicates tissue specific sialylation

(2009) Yunpeng Su et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synergistic regulation ofPseudomonas aeruginosa-induced cytokine production in human monocytes by mannose receptor and TLR2

(2009) Panagiota Xaplanteri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Schistosoma mansoniegg antigens induce Treg that participate in diabetes prevention in NOD mice

(2009) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glycan gimmickry by parasitic helminths: A strategy for modulating the host immune response?

(2009) I. van Die et al.   GLYCOBIOLOGY

Omega-1, a glycoprotein secreted bySchistosoma mansonieggs, drives Th2 responses

(2009) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

(2009) Svenja Steinfelder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alternatively Activated and Immunoregulatory Monocytes in Human Filarial Infections

(2009) Subash Babu et al.   JOURNAL OF INFECTIOUS DISEASES

Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Helminth infections associated with multiple sclerosis induce regulatory B cells

(2008) Jorge Correale et al.   ANNALS OF NEUROLOGY

Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis

(2008) Graham A. W. Rook   IMMUNOLOGY

The mannose receptor bindsTrichuris murisexcretory/secretory proteins but is not essential for protective immunity

(2008) Matthew L. deSchoolmeester et al.   IMMUNOLOGY

Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses

(2008) Sandra J van Vliet et al.   IMMUNOLOGY AND CELL BIOLOGY