Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas

Leiomyosarcoma With Alternative Lengthening of Telomeres Is Associated With Aggressive Histologic Features, Loss of ATRX Expression, and Poor Clinical Outcome

(2015) Jau-Yu Liau et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Alternative lengthening of telomeres phenotype in malignant vascular tumors is highly associated with loss of ATRX expression and is frequently observed in hepatic angiosarcomas

(2015) Jau-Yu Liau et al.   HUMAN PATHOLOGY

Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas

(2015) Jen-Chieh Lee et al.   MODERN PATHOLOGY

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas

(2015) Lauren Fishbein et al.   Nature Communications

Genomic landscape of paediatric adrenocortical tumours

(2015) Emilia M. Pinto et al.   Nature Communications

Novel oncogene and tumor suppressor mutations inKITandPDGFRAwild type gastrointestinal stromal tumors revealed by next generation sequencing

(2014) Jaclyn Frances Hechtman et al.   GENES CHROMOSOMES & CANCER

TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

(2014) Christian Koelsche et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

Dedifferentiation in Gastrointestinal Stromal Tumor to an Anaplastic KIT-negative Phenotype

(2013) Cristina R. Antonescu et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The Role of Telomeres in Stem Cells and Cancer

(2013) Cagatay Günes et al.   CELL

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

(2012) Xiao-Yang Liu et al.   ACTA NEUROPATHOLOGICA

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis

(2010) Lorenza Venturini et al.   BMC CANCER

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

(2010) L. H. Wong et al.   GENOME RESEARCH

Do Radiation-Associated Soft Tissue Sarcomas Have the Same Prognosis As Sporadic Soft Tissue Sarcomas?

(2010) Rebecca A. Gladdy et al.   JOURNAL OF CLINICAL ONCOLOGY

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Rhabdomyosarcomatous Differentiation in Gastrointestinal Stromal Tumors After Tyrosine Kinase Inhibitor Therapy

(2009) Bernadette Liegl et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Ionizing Radiation Up-regulates Telomerase Activity in Cancer Cell Lines by Post-translational Mechanism via Ras/Phosphatidylinositol 3-Kinase/Akt Pathway

(2009) R. Ram et al.   CLINICAL CANCER RESEARCH

Telomere length maintenance – an ALTernative mechanism

(2009) N.J. Royle et al.   CYTOGENETIC AND GENOME RESEARCH

Prevalence and clinical impact of anaplasia in childhood rhabdomyosarcoma

(2008) Stephen Qualman et al.   CANCER