Article
Cell Biology
Wei Zhuo, Meng Sun, Kun Wang, Lu Zhang, Kai Li, Danyang Yi, Mengjie Li, Qiang Sun, Xixi Ma, Wei Liu, Lisong Teng, Chengqi Yi, Tianhua Zhou
Summary: This study reveals the significance of PCIF1 and m(6)Am modification in gastric cancer. Increased expression of PCIF1 and m(6)Am modification are associated with gastric cancer progression and poor prognosis. Silencing PCIF1 inhibits the proliferation and invasion of gastric cancer cells, and suppresses tumor growth and metastasis in a mouse model. PCIF1 modifies TM9SF1 mRNA with m(6)Am, leading to decreased TM9SF1 translation. TM9SF1 reverses the effects of PCIF1 on gastric cancer cell aggressiveness.
Article
Multidisciplinary Sciences
Hongzhou Liu, Xueqin Wu, Tianrong Yang, Chen Wang, Fei Huang, Ying Xu, Jie Peng
Summary: NARFL deficiency impairs mitochondrial function in non-small cell lung cancer and promotes drug resistance and cell migration through the HIF-1 alpha-DNMT1 axis.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Jihee Lee, Kyoungwha Pang, Junil Kim, Eunji Hong, Jeeyun Lee, Hee Jin Cho, Jinah Park, Minjung Son, Sihyun Park, Minjung Lee, Akira Ooshima, Kyung-Soon Park, Han-Kwang Yang, Kyung-Min Yang, Seong-Jin Kim
Summary: The epithelial and mesenchymal isoform switches of LRRFIP2, regulated by ESRP1, are closely related to the metastatic potential of gastric cancer cells. The epithelial isoform of LRRFIP2 inhibits the oncogenic function of CARM1, while the mesenchymal isoform promotes liver metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Jing Zhao, Huiling Cao, Wenfan Zhang, Yongjuan Fan, Shujuan Shi, Rong Wang
Summary: SOX14 hypermethylation is significantly increased in cervical cancer tissues compared to normal tissues, showing potential as a diagnostic biomarker with high sensitivity and specificity. It has the ability to distinguish between normal, cervical intraepithelial neoplasia, and cancer samples, making it a valuable tool for early detection of cervical cancer.
Article
Oncology
Yo Han Hong, Nur Aziz, Jae Gwang Park, Dagyeong Lee, Jin Kyeong Kim, Seung A. Kim, Wooram Choi, Chae Young Lee, Hwa Pyoung Lee, Ha Thi Huyen Trang, Han Gyung Kim, Young-Jun Jeon, Bokyoung Kim, Younghoon Kim, Kyung-Hee Kim, Byong Chul Yoo, Jeung-Whan Han, Narayana Parameswaran, Ji Hye Kim, Hoon Hur, Jae Youl Cho
Summary: The study explored the pathological role of a nonhistone methyltransferase in gastric cancer (GC), identified EEF1AKMT3 as a novel tumor suppressive methyltransferase, and revealed its mechanism of action through regulating the methylation of MAP2K7 and the degradation of TP53. The findings suggest potential targeted therapy in GC by manipulating the dysregulated EEF1AKMT3/MAP2K7/TP53 signaling axis.
Article
Oncology
Pauline Ott, Marcos J. Arauzo-Bravo, Michele J. Hoffmann, Cedric Poyet, Marcelo L. Bendhack, Simeon Santourlidis, Lars Erichsen
Summary: Due to its high prevalence in various cancer types, THOR hypermethylation is suggested to be a common mechanism for telomerase activation in hTERT-expressing tumors. This study presents detailed DNA methylation profiles in urothelial cancer and proposes an efficient diagnostic approach. Additionally, the study provides insights into the epigenetic mechanism regulating hTERT expression.
Article
Biochemistry & Molecular Biology
Fernanda Wisnieski, Jaqueline Cruz Geraldis, Leonardo Caires Santos, Mariana Ferreira Leal, Danielle Queiroz Calcagno, Carolina Oliveira Gigek, Elizabeth Suchi Chen, Ana Carolina Anauate, Ricardo Artigiani, Samia Demachki, Paulo Pimentel Assumpcao, Laercio Gomes Lourenco, Carlos Haruo Arasaki, Julie Krainer, Stephan Pabinger, Rommel Rodriguez Burbano, Marilia Arruda Cardoso Smith
Summary: In this study, the research group identified a list of 83 genes potentially modulated by DNA methylation in GC cell lines, with LRRC37A2 playing a role in undifferentiated and poorly differentiated tumors. The study showed that reduced LRRC37A2 mRNA levels and increased LRRC37A2 exon methylation are associated with GC progression, emphasizing the potential utility of gene-related stratification for epigenetic therapy in GC patients.
Article
Oncology
Rocio Rosas-Alonso, Julian Colmenarejo-Fernandez, Olga Pernia, Carlos Rodriguez-Antolin, Isabel Esteban, Ismael Ghanem, Dario Sanchez-Cabrero, Itsaso Losantos-Garcia, Sara Palacios-Zambrano, Gema Moreno-Bueno, Javier de Castro, Virginia Martinez-Marin, Inmaculada Ibanez-de-Caceres
Summary: The study validated a quantitative assay for MGMT methylation detection by comparing a novel quantitative MSP with the conventional MSP in 100 FFPE glioblastoma samples. The results showed that dp_qMSP is an alternative methodology compatible with the conventional MSP, improving the standardization of the MGMT biomarker for reliable clinical use.
CLINICAL EPIGENETICS
(2021)
Review
Cell Biology
Zihao Zhang, Hao Wu, Wei Chong, Liang Shang, Changqing Jing, Leping Li
Summary: Gastric cancer is a high-incidence cancer worldwide, and early diagnosis and precise treatment are crucial. Liquid biopsy, especially the detection of circulating tumor cells, circulating tumor DNA, and circulating free DNA, has shown promising potential in monitoring gastric cancer occurrence and recurrence, evaluating prognosis, and assessing treatment response.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin
Summary: The abnormal expression of NR2F1-AS1 in gastric cancer is related to its correlation with NR2F1 expression, as well as their response to epithelial-to-mesenchymal transition signaling. NR2F1-AS1 modulates the miR-29a-3p/VAMP7 axis and plays a crucial role in the progression of gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
P. Firdous, K. Nissar, S. R. Masoodi, J. A. Wani, T. Hassan, B. A. Ganai
Summary: This study aims to evaluate the promoter methylation and expression profile of the most common MODY causing gene, HNF1 alpha, in Kashmiri MODY patients and found that HNF1 alpha is strongly upregulated in MODY cases. The study also shows that as glucose dysregulation progresses, the expression of HNF1 alpha rises.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Oncology
Dora Londra, Sophia Mastoraki, Evangelos Bournakis, Martha Zavridou, Anastasios Thanos, Theodoros Rampias, Evi S. Lianidou
Summary: Liquid biopsy allows real-time monitoring of tumor evolution and therapy response by analyzing CTCs and ctDNA. This study investigated USP44 promoter methylation in plasma cfDNA of prostate cancer patients for the first time, revealing a significant association with overall survival in metastatic prostate cancer patients.
Article
Oncology
Haojie Li, Junjie Zhao, Jie Sun, Chenyu Tian, Quan Jiang, Chen Ding, Qiangjun Gan, Ping Shu, Xuefei Wang, Jing Qin, Yihong Sun
Summary: This study aimed to investigate the role of SFRP4 in gastric cancer tumorigenesis. Results showed that high expression of SFRP4 was associated with poor prognosis in gastric cancer patients, promoting tumor growth, although its effects could be suppressed by specific drugs.
MOLECULAR CANCER RESEARCH
(2021)
Article
Cell Biology
Ou Li, Cheng Zhao, Jian Zhang, Feng-Nan Li, Zi-Yi Yang, Shi-Lei Liu, Chen Cai, Zi-Yao Jia, Wei Gong, Yi-Jun Shu, Ping Dong
Summary: This study found that UBAP2L is highly expressed in gastric cancer and is associated with poor prognosis. Knockdown of UBAP2L inhibits the migration and invasion abilities of gastric cancer cells, while its overexpression enhances these abilities. Experimental evidence suggests that UBAP2L regulates GC metastasis through the activation of the PI3K/AKT pathway.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Martha Zavridou, Areti Strati, Evangelos Bournakis, Stavroula Smilkou, Victoria Tserpeli, Evi Lianidou
Summary: Liquid biopsy based on CTCs and ctDNA allows real-time monitoring of tumor progression and treatment efficacy. A study on gene expression and DNA methylation markers in CTCs and plasma-derived exosomes in metastatic prostate cancer patients revealed higher positivity in markers in CTCs compared to exosomes, correlating with overall survival.
Article
Genetics & Heredity
Giovana E. da Costa, Giordane L. Fernandes, Juliana C. G. Rodrigues, Diana F. da V. B. Leal, Lucas F. Pastana, Esdras E. B. Pereira, Paulo P. Assumpcao, Rommel M. R. Burbano, Sidney E. B. dos Santos, Joao F. Guerreiro, Marianne R. Fernandes, Ney P. C. dos Santos
Summary: Autism spectrum disorder is a neurodevelopmental disorder affecting one in 160 children worldwide. Genetic factors, including CHD8, SCN2A, FOXP1, and SYNGAP1 genes, play a role in the pathophysiology of autism. This study investigated the genetic profile of Amazonian Amerindians, identifying 16 variants with significantly different frequencies from other populations. Understanding these variants can contribute to the diagnosis and pathophysiology of autism in Amerindians and admixed populations.
Article
Genetics & Heredity
Anna Karolina Silva Ramos, Erica Carine Campos Caldas-Rosa, Barbara Merfort Ferreira, Beatriz Ribeiro Versiani, Patricia Natalia Moretti, Silviene Fabiana de Oliveira, Aline Pic-Taylor, Juliana F. Mazzeu
Summary: The ZDHHC9 gene mutation leads to intellectual disabilities and symptoms such as low IQ, developmental delay, facial dysmorphisms, and skeletal defects. Although there are differences in clinical manifestations among different patients, intellectual disabilities and developmental delay are reported in all cases. These mutations mainly occur in the arginine residues located in the cytoplasmic domains of the protein and may be hotspot mutations.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Biochemistry & Molecular Biology
Victoria Mae Tsuruzaki Shinkai, Izana Marize Oliveira Sampaio, Eline Gomes dos Santos, Adan Jesus Galue-Parra, Dionisia Pelaes Ferreira, Drielly Dayanne Monteiro Santos Baliza, Neidiane Farias Ramos, Raphael Sanzio Pimenta, Rommel Mario Rodriguez Burbano, Chubert Bernardo Castro Sena, Barbarella Matos Macchi, Irlon Maciel Ferreira, Edilene Oliveira Silva, Jose Luiz Martins do Nascimento
Summary: Gliomas are common malignant brain tumors with limited treatment options. Plant-derived quinone derivatives, such as eleutherine, have shown potential anti-glioma activity. This study found that eleutherine inhibits glioma cell proliferation, migration, and invasion, and induces apoptosis. These results suggest the potential clinical use of eleutherine for treating gliomas.
Article
Genetics & Heredity
Antonio A. C. Modesto, Milene R. de Moraes, Cristina M. D. Valente, Marta S. C. R. Costa, Diana F. da V. B. Leal, Esdras E. B. Pereira, Marianne R. Fernandes, Jhully A. dos S. Pinheiro, Karla B. C. C. Pantoja, Fabiano C. Moreira, Rommel M. R. Burbano, Paulo P. de Assumpcao, Ney P. C. dos Santos, Sidney E. B. dos Santos
Summary: Gastric cancer is a complex and aggressive disease with a high prevalence and mortality worldwide. INDELs in miRNA and its target sites have been found to play an important role in the development of cancer. This study identified several variants (hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, and hsa-miR-3652) associated with gastric cancer susceptibility and clinical features.
Review
Genetics & Heredity
Dalileia Aparecida Santana, Marilia de Arruda Cardoso Smith, Elizabeth Suchi Chen
Summary: Due to the combination of genetic variants and environmental factors, epigenetic modifications are predicted to play a role in the etiopathology of Late-onset Alzheimer's disease (LOAD). This review highlights the main histone modifications and their functional role, including histone acetylation, methylation, and phosphorylation, and discusses changes in these modifications during the aging process and in Alzheimer's disease (AD). The review also discusses the potential use of epigenetic drugs, such as histone deacetylase (HDAC) inhibitors, for the treatment of AD.
Article
Cell Biology
Bruno Mari Fredi, Roger Willian De Labio, Lucas Trevizani Rasmussen, Eduardo Federighi Baisi Chagas, Elizabeth Suchi Chen, Gustavo Turecki, Marilia de Arruda Cardoso Smith, Spencer Luiz Marques Payao
Summary: Alzheimer's disease is a progressive neuroinflammatory and neurodegenerative disorder that affects different regions of the brain. The accumulation of beta-amyloid protein, formation of neurofibrillary tangles, and inflammatory processes contribute to its pathophysiology. CDK10 and CDK11 have high expression in AD patients compared to control, and they present a positive correlation of gene expression in the analyzed groups and tissues, suggesting their important role in the pathogenesis of AD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kelly Cristina Oliveira de Albuquerque, Natasha Costa da Rocha Galucio, Gleison Goncalves Ferreira, Ana Carolina Sousa Quaresma, Valdicley Vieira Vale, Marcelo de Oliveira Bahia, Rommel Mario Rodriguez Burbano, Fabio Alberto de Molfetta, Sandro Percario, Maria Fani Dolabela
Summary: This study evaluated the genotoxicity of Ethanol Extract (EEEp), Dichloromethane Fraction (FDCMEp) and isoeleutherin isolated from Eleutherine plicata, using the micronucleus test and molecular docking. Isoeleutherin and analogues were subjected to in silico toxicity prediction, and compounds free of toxicological risks (CP13, CP14, CP17 and isoeleutherin) were selected for molecular docking in Topoisomerase II. The results showed that the structural changes of isoeleutherin led to the obtaining of a molecule with a lower mutagenic potential, and the CP13 can be considered a prototype compound for the development of new molecules with pharmacological potential.
Article
Genetics & Heredity
Esdras E. B. Pereira, Antonio A. C. Modesto, Bruno M. M. Fernandes, Rommel M. R. Burbano, Paulo P. P. Assumpcao, Marianne R. R. Fernandes, Joao F. Guerreiro, Sidney E. B. dos Santos, Ney P. C. dos Santos
Summary: A study conducted in the Brazilian Amazon found that five genetic variants (IL-1A, NFKB1, PAR1, TP53, and UCP2) were significantly associated with the development of non-small cell lung cancer (NSCLC). Variants in NFKB1, PAR1, and TP53 were negatively correlated with NSCLC, while variants in IL-1A and UCP2 were positively correlated. These findings suggest the importance of genetic variations in NSCLC susceptibility.
Article
Genetics & Heredity
Roberta Borges Andrade, Amanda de Nazare Cohen-Paes, Diana Feio da Veiga Borges Leal, Karla Beatriz Cardias Cereja Pantoja, Laura Patricia Albarello Gellen, Darlen Cardoso de Carvalho, Tatiane Piedade de Souza, Marianne Rodrigues Fernandes, Paulo Pimentel de Assumpcao, Rommel Mario Rodriguez Burbano, Sidney Emanuel Batista dos Santos, Ney Pereira Carneiro dos Santos
Summary: Gastric cancer is a major concern in Brazil, particularly in the Amazon region. This study investigated the association between genetic variations in miRNA processing genes and gastric cancer risk in the Brazilian Amazon population. The findings suggest that the GG genotype of the rs10739971 variant is associated with a lower risk of gastric cancer. This is the first study to report this association in this unique population.
Article
Pharmacology & Pharmacy
Daiane M. S. Brito, Odnan G. Lima, Felipe P. Mesquita, Emerson L. da Silva, Maria E. A. de Moraes, Rommel M. R. Burbano, Raquel C. Montenegro, Pedro F. N. Souza
Summary: Gastric cancer is a complex and heterogeneous disease, with a poor prognosis. Researchers identified highly expressed genes in gastric cancer cells, such as AJUBA, CD80, and NOLC1, and discovered three molecules that target these genes using virtual screening. The molecules showed favorable pharmacokinetic and pharmacodynamic properties.
Article
Health Care Sciences & Services
Marta Solange Camarinha Ramos Costa, Marianne Rodrigues Fernandes, Esdras Edgar Batista Pereira, Diana Feio da Veiga Borges Leal, Rita de Cassia Calderaro Coelho, Elisa da Silva Menezes, Antonio Andre Conde Modesto, Paulo Pimentel de Assumpcao, Rommel Mario Rodriguez Burbano, Sidney Emanuel Batista dos Santos, Ney Pereira Carneiro dos Santos
Summary: Breast cancer is the most common malignant disease and the leading cause of mortality among women worldwide. Taxanes are commonly used drugs for treating breast cancer. This study focuses on the clinical-epidemiological profile, risk factors, and toxicities of taxane treatment in breast cancer patients in the Amazon region. The findings highlight the importance of early detection, comprehensive risk factor assessment, and effective management of treatment toxicities.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Health Care Sciences & Services
Barbara Ferraz Barbosa, Francisco Cezar Aquino de Moraes, Camila Bordignon Barbosa, Plinio Takashi Karubi Palavicini Santos, Izael Pereira da Silva, Bruno Araujo Alves da Silva, Jamile Cristine Marques Barros, Rommel Mario Rodriguez Burbano, Ney Pereira Carneiro dos Santos, Marianne Rodrigues Fernandes
Summary: This meta-analysis study demonstrates the efficacy and safety of setmelanotide in treating severe obesity linked to MC4R deficiency. However, its use may be associated with a higher risk of skin hyperpigmentation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Patrick Douglas Correa Pereira, Ediely Pereira Henrique, Emanuel Ramos da Costa, Anderson de Jesus Falcao, Mauro Andre Damasceno de Melo, Maria Paula Cruz Schneider, Rommel Mario Rodriguez Burbano, Daniel Guerreiro Diniz, Nara Gyzely de Morais Magalhaes, David Francis Sherry, Cristovam Wanderley Picanco Diniz, Cristovam Guerreiro-Diniz
Summary: Migrant birds prepare differently for spring breeding and autumn migration. By analyzing gene expressions in different tissues, this study found significant changes in glial cells and neurogenesis in the brain of semipalmated sandpipers during the wintering period. The gene expressions in newly arrived and premigratory birds were associated with neurogenesis, metabolic pathways, glial changes, immune response, inflammatory cytokines, and cell death pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Leticia Martins Lamarao, Angelita Silva Miranda Correa, Renata Bezerra Hermes de Castro, Carlos Eduardo de Melo Amaral, Patricia Danin Jordao Monteiro, Mauricio Koury Palmeira, Luane Nascimento Lopes, Angela Neves Oliveira, Maria Salete Maciel de Lima, Caroline Aquino Moreira-Nunes, Rommel Rodriguez Burbano
Summary: This study investigated the prevalence of arbovirus infections in blood donors in northern Brazil and found low prevalence rates for dengue virus and chikungunya virus. Individual screening of blood samples would not be necessary, but using nucleic acid testing in sample pools could safely detect these viruses.
MEDICINA-LITHUANIA
(2023)
Article
Biochemistry & Molecular Biology
Amanda Merces, Rebecca da-Silva-Cruz, Caio S. Silva, Rommel Burbano, Andrea Ribeiro-dos-Santos, Giovanna C. Cavalcante
Summary: This study investigated the distribution of genetic variants in breast cancer and found that breastfeeding and cancer history are factors related to the occurrence of breast cancer. The study contributes to a better understanding of cell death resistance and apoptosis in breast cancer, highlighting the impact of cancer history and breastfeeding on breast cancer development.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
