Reciprocal Interactions of Mitochondria and the Neuroimmunoendocrine System in Neurodegenerative Disorders: An Important Role for Melatonin Regulation

Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death

(2018) Tomas Gutiérrez et al.   CELL CALCIUM

Synchronizing effects of melatonin on diurnal and circadian rhythms

(2018) Martina Pfeffer et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects

(2018) A. F. De Nicola et al.   JOURNAL OF NEUROENDOCRINOLOGY

Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition

(2018) George Anderson   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Emerging chemical therapies targeting 5-hydroxytryptamine in the treatment of Alzheimer’s disease

(2017) Amanda Calhoun et al.   EXPERT OPINION ON EMERGING DRUGS

Bax, Bak and beyond - mitochondrial performance in apoptosis

(2017) Aida Peña-Blanco et al.   FEBS Journal

A Nigro−Vagal Pathway Controls Gastric Motility and Is Affected in a Rat Model of Parkinsonism

(2017) Laura Anselmi et al.   GASTROENTEROLOGY

Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons

(2017) Roberto Piacentini et al.   GLIA

The Spleen: A Hub Connecting Nervous and Immune Systems in Cardiovascular and Metabolic Diseases

(2017) Andrea Lori et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocytes take the stage in a tale of signaling-metabolism coupling

(2017) Lasse K. Bak   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

(2017) Ethan Stolzenberg et al.   Journal of Innate Immunity

Mitochondria as Molecular Platforms Integrating Multiple Innate Immune Signalings

(2017) Marie Monlun et al.   JOURNAL OF MOLECULAR BIOLOGY

Non-CNS pathogenic origin of Parkinson’s disease

(2017) Humdoon Choudhry et al.   JOURNAL OF NEUROLOGY

Ciproxifan improves cholinergic transmission, attenuates neuroinflammation and oxidative stress but does not reduce amyloid level in transgenic mice

(2017) Vasudevan Mani et al.   LIFE SCIENCES

Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life

(2017) Cinthya Gomes et al.   MOLECULAR NEUROBIOLOGY

Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease

(2017) María José Pérez et al.   MOLECULAR NEUROBIOLOGY

TFH-derived dopamine accelerates productive synapses in germinal centres

(2017) Ilenia Papa et al.   NATURE

Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism

(2017) Jacqueline A. Gleave et al.   NEUROBIOLOGY OF DISEASE

Possible concurrence of TDP-43, tau and other proteins in amyotrophic lateral sclerosis/frontotemporal lobar degeneration

(2017) Takahiro Takeda   NEUROPATHOLOGY

Review: Tau in biofluids - relation to pathology, imaging and clinical features

(2017) H. Zetterberg   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain

(2017) Julien Gibon et al.   NEUROSCIENTIST

Bax and Bak Pores: Are We Closing the Circle?

(2017) Katia Cosentino et al.   TRENDS IN CELL BIOLOGY

Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer’s disease core biomarkers in Lewy body disorders and Alzheimer’s dementia

(2017) Davide Chiasserini et al.   Alzheimers Research & Therapy

Role of Atypical Chemokine Receptors in Microglial Activation and Polarization

(2017) Valentina Salvi et al.   Frontiers in Aging Neuroscience

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries

(2017) Nafiisha Genet et al.   Frontiers in Physiology

Neuroactive Steroids: Receptor Interactions and Responses

(2017) Kald Beshir Tuem et al.   Frontiers in Neurology

The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer’s Disease

(2017) Juanjuan Zhao et al.   Frontiers in Neurology

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

(2017) Chiara La Morgia et al.   Frontiers in Neurology

Circadian Variations of Cortisol, Melatonin and Lymphocyte Subpopulations in Geriatric Age

(2017) G. Mazzoccoli et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells

(2016) Lilla Prenek et al.   APOPTOSIS

Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption

(2016) Susu Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Glutamate excitotoxicity and Ca 2+ -regulation of respiration: Role of the Ca 2+ activated mitochondrial transporters (CaMCs)

(2016) Carlos B. Rueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial cytopathies

(2016) Ayman W. El-Hattab et al.   CELL CALCIUM

Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3

(2016) Nishant P. Visavadiya et al.   Cell Communication and Signaling

Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways

(2016) George Anderson et al.   CURRENT PHARMACEUTICAL DESIGN

Glioma: Tryptophan Catabolite and Melatoninergic Pathways Link microRNA, 14-3- 3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes

(2016) Timothy V. Beischlag et al.   CURRENT PHARMACEUTICAL DESIGN

Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin

(2016) Moses Rodriguez et al.   CURRENT PHARMACEUTICAL DESIGN

Gut Permeability and Microbiota in Parkinson’s Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways

(2016) George Anderson et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroimmune Crosstalk in CNS Disorders: The Histamine Connection

(2016) Ramón Cacabelos et al.   CURRENT PHARMACEUTICAL DESIGN

Overlapping the Tryptophan Catabolite (TRYCAT) and Melatoninergic Pathways in Alzheimer';s Disease

(2016) Michael Maes et al.   CURRENT PHARMACEUTICAL DESIGN

The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders

(2016) Gerwyn Morris et al.   CURRENT PHARMACEUTICAL DESIGN

Transcriptional Analysis of Blood Lymphocytes and Skin Fibroblasts, Keratinocytes, and Endothelial Cells as a Potential Biomarker for Alzheimer’s Disease

(2016) Marat A. Mukhamedyarov et al.   JOURNAL OF ALZHEIMERS DISEASE

Current status and future perspectives: TSPO in steroid neuroendocrinology

(2016) Vimal Selvaraj et al.   JOURNAL OF ENDOCRINOLOGY

Substance P–mediated chemokine production promotes monocyte migration

(2016) Sergei Spitsin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial calcium uniporter inhibition attenuates mouse bone marrow-derived mast cell degranulation induced by beta-1,3-glucan

(2016) Dang Van Cuong et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways

(2016) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Modulation of Diabetes-Induced Oxidative Stress, Apoptosis, and Ca2+ Entry Through TRPM2 and TRPV1 Channels in Dorsal Root Ganglion and Hippocampus of Diabetic Rats by Melatonin and Selenium

(2016) Mehmet Cemal Kahya et al.   MOLECULAR NEUROBIOLOGY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Mitochondrial disease and endocrine dysfunction

(2016) Jasmine Chow et al.   Nature Reviews Endocrinology

Genetic and biochemical intricacy shapes mitochondrial cytopathies

(2016) Douglass M. Turnbull et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial Superoxide Signaling Contributes to Norepinephrine-Mediated T-Lymphocyte Cytokine Profiles

(2016) Adam J. Case et al.   PLoS One

Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging

(2016) Michael A. Paltsev et al.   Oncotarget

Neuronal Nitric Oxide Synthase in Vascular Physiology and Diseases

(2016) Eduardo D. Costa et al.   Frontiers in Physiology

Non-Amyloid-β Component of Human α-Synuclein Oligomers Induces Formation of New Aβ Oligomers: Insight into the Mechanisms That Link Parkinson’s and Alzheimer’s Diseases

(2015) Yoav Atsmon-Raz et al.   ACS Chemical Neuroscience

The SR/ER-mitochondria calcium crosstalk is regulated by GSK3β during reperfusion injury

(2015) L Gomez et al.   CELL DEATH AND DIFFERENTIATION

Interleukin-1 as a pharmacological target in acute brain injury

(2015) David Brough et al.   EXPERIMENTAL PHYSIOLOGY

Mitochondrial regulation of macrophage cholesterol homeostasis

(2015) Annette Graham   FREE RADICAL BIOLOGY AND MEDICINE

Gender-Associated Differential Expression of Cytokines in Specific Areas of the Brain During Helminth Infection

(2015) Lorena López-Griego et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice

(2015) Marissa J. Schafer et al.   NEUROBIOLOGY OF AGING

Transport and diffusion of Tau protein in neurons

(2014) Tim Scholz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TRYCAT Pathways Link Peripheral Inflammation, Nicotine, Somatization and Depression in the Etiology and Course of Parkinson’s Disease

(2014) George Anderson et al.   CNS & Neurological Disorders-Drug Targets

Local Melatonin Regulates Inflammation Resolution: A Common Factor in Neurodegenerative, Psychiatric and Systemic Inflammatory Disorders

(2014) George Anderson et al.   CNS & Neurological Disorders-Drug Targets

C and APUD Cells and Endocrine Tumours. Pearse’s Laboratory in the Years 1965–1969: A Personal Recollection

(2014) Gianni Bussolati   ENDOCRINE PATHOLOGY

OXPHOS dysfunction regulates integrin- 1 modifications and enhances cell motility and migration

(2014) J. B. Nunes et al.   HUMAN MOLECULAR GENETICS

A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response

(2014) Julia Cruces et al.   JOURNAL OF NEUROIMMUNOLOGY

The Effects of Neurotrophins and the Neuropeptides VIP and PACAP on HIV-1 Infection: Histories with Opposite Ends

(2014) Thiago Moreno L. Souza et al.   NEUROIMMUNOMODULATION

Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression

(2014) George Anderson et al.   Pharmacological Reports

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro

(2014) Pan Guo et al.   TOXICOLOGICAL SCIENCES

Inflammasomes in neuroinflammation and changes in brain function: a focused review

(2014) Gaurav Singhal et al.   Frontiers in Neuroscience

Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function

(2013) Tao Luo et al.   BASIC RESEARCH IN CARDIOLOGY

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

(2013) Tim Vanuytsel et al.   GUT

The role of melatonin in the cells of the innate immunity: a review

(2013) Juan R. Calvo et al.   JOURNAL OF PINEAL RESEARCH

Steroid hormone synthesis in mitochondria

(2013) Walter L. Miller   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function

(2013) Adinarayana Marada et al.   MOLECULAR BIOLOGY OF THE CELL

Neurodegeneration in Parkinson's Disease: Interactions of Oxidative Stress, Tryptophan Catabolites and Depression with Mitochondria and Sirtuins

(2013) George Anderson et al.   MOLECULAR NEUROBIOLOGY

Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

(2012) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects

(2012) George Anderson et al.   METABOLIC BRAIN DISEASE

NF-κB Drives the Synthesis of Melatonin in RAW 264.7 Macrophages by Inducing the Transcription of the Arylalkylamine-N-Acetyltransferase (AA-NAT) Gene

(2012) Sandra Marcia Muxel et al.   PLoS One

Stimulated Human Mast Cells Secrete Mitochondrial Components That Have Autocrine and Paracrine Inflammatory Actions

(2012) Bodi Zhang et al.   PLoS One

Putative neuroprotective agents in neuropsychiatric disorders

(2012) Seetal Dodd et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs

(2011) Madhusudanarao Vuda et al.   Innate Immunity

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatonin

(2010) G. Anderson et al.   EUROPEAN JOURNAL OF NEUROLOGY

Neuronal–immune interactions in mediating stress effects in the etiology and course of schizophrenia: Role of the amygdala in developmental co-ordination

(2010) George Anderson   MEDICAL HYPOTHESES

Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice

(2010) J.J. García et al.   NEUROBIOLOGY OF AGING

Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice

(2010) Niels J. Rupp et al.   NEUROBIOLOGY OF AGING

N-acetylserotonin activates TrkB receptor in a circadian rhythm

(2010) Sung-Wuk Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Worldwide variation in the doubling time of Alzheimer's disease incidence rates

(2008) Kathryn Ziegler-Graham et al.   Alzheimers & Dementia

Neuroprotective role of δ-opioid receptors against mitochondrial respiratory chain injury

(2008) Min Zhu et al.   BRAIN RESEARCH