Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life

The acute effect of intravenous lipopolysaccharide injection on serum and intrafollicular HDL components and gene expression in granulosa cells of the bovine dominant follicle

(2017) Felipe Terres de Campos et al.   THERIOGENOLOGY

Inter-relation between brain-derived neurotrophic factor and antioxidant enzymes in bipolar disorder

(2016) Rodrigo B Mansur et al.   BIPOLAR DISORDERS

Oxidative and nitrosative stress pathways in the brain of socially isolated adult male rats demonstrating depressive- and anxiety-like symptoms

(2016) Dragana Filipović et al.   Brain Structure & Function

Association between depression and periodontitis: a systematic review and meta-analysis

(2016) Milena Moreira Araújo et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts

(2016) Thanuja D. K. Herath et al.   Scientific Reports

So depression is an inflammatory disease, but where does the inflammation come from?

(2016) Michael Berk et al.   BMC Medicine

Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

(2015) Tania O Crișan et al.   ANNALS OF THE RHEUMATIC DISEASES

The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue

(2015) Kurt Lucas et al.   CNS & Neurological Disorders-Drug Targets

Prevalence of Depression in Patients With Hypertension

(2015) Zhanzhan Li et al.   MEDICINE

Association of Periodontitis and Subsequent Depression

(2015) Chih-Chao Hsu et al.   MEDICINE

Chronic unpredictable stress impairs endogenous antioxidant defense in rat brain

(2015) Yi Che et al.   NEUROSCIENCE LETTERS

Markers of Oxidative Stress and Neuroprogression in Depression Disorder

(2015) Magdaléna Vaváková et al.   Oxidative Medicine and Cellular Longevity

A Meta-Analysis of Oxidative Stress Markers in Depression

(2015) Tao Liu et al.   PLoS One

Clinical investigation of bacterial species and endotoxin in endodontic infection and evaluation of root canal content activity against macrophages by cytokine production

(2014) Frederico C. Martinho et al.   Clinical Oral Investigations

The association between poor dental health and depression: findings from a large-scale, population-based study (the NHANES study)

(2014) Adrienne O’Neil et al.   GENERAL HOSPITAL PSYCHIATRY

Lowered plasma paraoxonase (PON)1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism–smoking interactions differentially predict the odds of major depression and bipolar disorder

(2014) Chiara Cristina Bortolasci et al.   JOURNAL OF AFFECTIVE DISORDERS

Signaling Pathways Activation by Primary Endodontic Infectious Contents and Production of Inflammatory Mediators

(2014) Frederico C. Martinho et al.   JOURNAL OF ENDODONTICS

Oxidative & nitrosative stress in depression: Why so much stress?

(2014) Steven Moylan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4months

(2013) Marta Kubera et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways in the Etiology of Depression: Therapeutic Implications

(2013) George Anderson et al.   CNS DRUGS

Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts

(2013) Heber Odebrecht Vargas et al.   JOURNAL OF AFFECTIVE DISORDERS

Short-term inhalation of nitric oxide inhibits activations of toll-like receptor 2 and 4 in the lung after ischemia-reperfusion injury in mice

(2013) Zhi-kun Zheng et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

(2013) Kurt Lucas et al.   MOLECULAR NEUROBIOLOGY

In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes

(2012) M. Maes et al.   ACTA PSYCHIATRICA SCANDINAVICA

Improved detection of advanced oxidation protein products in plasma

(2012) Marita Hanasand et al.   CLINICA CHIMICA ACTA

Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut

(2012) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder

(2012) Piotr Gałecki et al.   JOURNAL OF AFFECTIVE DISORDERS

Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression

(2012) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Prevalence of Periodontitis in Adults in the United States: 2009 and 2010

(2012) P.I. Eke et al.   JOURNAL OF DENTAL RESEARCH

Oral Inflammatory Diseases and Systemic Inflammation: Role of the Macrophage

(2012) Hatice Hasturk et al.   Frontiers in Immunology

Oxidative stress and hematological profiles of advanced breast cancer patients subjected to paclitaxel or doxorubicin chemotherapy

(2011) C. Panis et al.   BREAST CANCER RESEARCH AND TREATMENT

The association between depression and anxiety and use of oral health services and tooth loss

(2011) Catherine A. Okoro et al.   COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY

IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: New pathways that underpin the inflammatory and neuroprogressive pathophysiology

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Comparison of Endotoxin Levels in Previous Studies on Primary Endodontic Infections

(2011) Frederico C. Martinho et al.   JOURNAL OF ENDODONTICS

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Analysis of socio-demographic and systemic health factors and the normative conditions of oral health care in a population of the Brazilian elderly

(2010) Danilo Cangussu Mendes et al.   GERODONTOLOGY

Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease

(2010) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Multiple aberrations in shared inflammatory and oxidative & nitrosative stress (IO&NS) pathways explain the co-association of depression and cardiovascular disorder (CVD), and the increased risk for CVD and due mortality in depressed patients

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Plasma-Advanced Oxidation Protein Products Are Potent High-Density Lipoprotein Receptor Antagonists In Vivo

(2009) Gunther Marsche et al.   CIRCULATION RESEARCH

Antioxidative enzymes and increased oxidative stress in depressive women

(2009) Jana Kodydková et al.   CLINICAL BIOCHEMISTRY

Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease

(2009) Toshiaki Ara et al.   JOURNAL OF PERIODONTAL RESEARCH

Determination of Paraoxonase 1 Status Without the Use of Toxic Organophosphate Substrates

(2008) Rebecca J. Richter et al.   Circulation-Cardiovascular Genetics

Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms

(2008) Michael Maes   CURRENT OPINION IN PSYCHIATRY

Quantification of Endotoxins and Cultivable Bacteria in Root Canal Infection before and after Chemomechanical Preparation with 2.5% Sodium Hypochlorite

(2008) Frederico C. Martinho et al.   JOURNAL OF ENDODONTICS

Periodontal Disease and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis

(2008) Linda L. Humphrey et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Uric Acid: The Oxidant-Antioxidant Paradox

(2008) Yuri Y. Sautin et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS