Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain

Neurotrophins Enhance CaMKII Activity and Rescue Amyloid-β-Induced Deficits in Hippocampal Synaptic Plasticity

(2017) Yan Zeng et al.   JOURNAL OF ALZHEIMERS DISEASE

The X-linked inhibitor of apoptosis regulates long-term depression and learning rate

(2016) Julien Gibon et al.   FASEB JOURNAL

Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors

(2016) Catia C. Proenca et al.   JOURNAL OF NEUROCHEMISTRY

Neurotrophin-3 Regulates Synapse Development by Modulating TrkC-PTP  Synaptic Adhesion and Intracellular Signaling Pathways

(2016) K. A. Han et al.   JOURNAL OF NEUROSCIENCE

Control of spine maturation and pruning through proBDNF synthesized and released in dendrites

(2016) Lauren L. Orefice et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

SorCS2 is required for BDNF-dependent plasticity in the hippocampus

(2016) S Glerup et al.   MOLECULAR PSYCHIATRY

Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear

(2016) Davide D'Amico et al.   NEUROPSYCHOPHARMACOLOGY

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

(2016) Sumangali Kailainathan et al.   PHARMACOLOGICAL RESEARCH

BDNF pro-peptide regulates dendritic spines via caspase-3

(2016) J Guo et al.   Cell Death & Disease

Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex

(2016) Julien Gibon et al.   Molecular Brain

Neurotrophin-3 Enhances the Synaptic Organizing Function of TrkC-Protein Tyrosine Phosphatase   in Rat Hippocampal Neurons

(2015) I. Ammendrup-Johnsen et al.   JOURNAL OF NEUROSCIENCE

proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons

(2015) J. Gibon et al.   JOURNAL OF NEUROSCIENCE

Effect of neurotrophin-3 precursor on glutamate-induced calcium homeostasis deregulation in rat cerebellum granule cells

(2015) Dina R. Safina et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Spontaneous Activity Drives Local Synaptic Plasticity In Vivo

(2015) Johan Winnubst et al.   NEURON

proBDNF Attenuates Hippocampal Neurogenesis and Induces Learning and Memory Deficits in Aged Mice

(2015) Jia Chen et al.   NEUROTOXICITY RESEARCH

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

(2015) Toshiyuki Mizui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP

(2014) Hyungju Park et al.   NEURON

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

(2014) Jianmin Yang et al.   Cell Reports

ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

(2013) C Tiveron et al.   CELL DEATH AND DIFFERENTIATION

Plasticity and metaplasticity of adult rat hippocampal mossy fibers induced by neurotrophin-3

(2013) L. E. Ramos-Languren et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

ProBDNF and Mature BDNF as Punishment and Reward Signals for Synapse Elimination at Mouse Neuromuscular Junctions

(2013) H. S. Je et al.   JOURNAL OF NEUROSCIENCE

proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus

(2013) Jingjing Guo et al.   NEUROCHEMICAL RESEARCH

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

(2013) Agustin Anastasia et al.   Nature Communications

Impact of the NGF Maturation and Degradation Pathway on the Cortical Cholinergic System Phenotype

(2012) S. Allard et al.   JOURNAL OF NEUROSCIENCE

Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses

(2012) H. S. Je et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergent Roles ofp75NTRand Trk Receptors in BDNF's Effects on Dendritic Spine Density and Morphology

(2012) Christopher A. Chapleau et al.   NEURAL PLASTICITY

The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease

(2011) Aristotle N. Voineskos et al.   ARCHIVES OF GENERAL PSYCHIATRY

Roles of p75NTR, Long-Term Depression, and Cholinergic Transmission in Anxiety and Acute Stress Coping

(2011) Keri Martinowich et al.   BIOLOGICAL PSYCHIATRY

Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons

(2011) Jacob Tauris et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex

(2010) Zizhen Zhang et al.   HIPPOCAMPUS

The BDNF Val66Met Polymorphism Impairs NMDA Receptor-Dependent Synaptic Plasticity in the Hippocampus

(2010) I. Ninan et al.   JOURNAL OF NEUROSCIENCE

Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth

(2010) S. Rauskolb et al.   JOURNAL OF NEUROSCIENCE

ProNGF Induces PTEN via p75NTR to Suppress Trk-Mediated Survival Signaling in Brain Neurons

(2010) W. Song et al.   JOURNAL OF NEUROSCIENCE

Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons

(2010) Yuanyuan Ji et al.   NATURE NEUROSCIENCE

Pro-BDNF–induced synaptic depression and retraction at developing neuromuscular synapses

(2009) Feng Yang et al.   JOURNAL OF CELL BIOLOGY

NGF Is Essential for Hippocampal Plasticity and Learning

(2009) J. M. Conner et al.   JOURNAL OF NEUROSCIENCE

Mature BDNF, But Not proBDNF, Reduces Excitability of Fast-Spiking Interneurons in Mouse Dentate Gyrus

(2009) M. M. Holm et al.   JOURNAL OF NEUROSCIENCE

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

Brain derived neurotrophic factor and neurotrophin-4 employ different intracellular pathways to modulate norepinephrine uptake and release in rat hypothalamus

(2009) M. Rodríguez Fermepin et al.   NEUROPEPTIDES

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

(2009) G. Nagappan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

(2008) Raya Al-Shawi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chronic Exposure to Nerve Growth Factor Increases Acetylcholine and Glutamate Release from Cholinergic Neurons of the Rat Medial Septum and Diagonal Band of Broca via Mechanisms Mediated by p75NTR

(2008) C. Y. L. Huh et al.   JOURNAL OF NEUROSCIENCE

Transgenic Mice Lacking NMDAR-Dependent LTD Exhibit Deficits in Behavioral Flexibility

(2008) Russell E. Nicholls et al.   NEURON

Linking Cellular Mechanisms to Behavior: Entorhinal Persistent Spiking and Membrane Potential Oscillations May Underlie Path Integration, Grid Cell Firing, and Episodic Memory

(2008) Michael E. Hasselmo et al.   NEURAL PLASTICITY