Interleukin-1 as a pharmacological target in acute brain injury

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term functional recovery and compensation after cerebral ischemia in rats

(2014) Sylvie Girard et al.   BEHAVIOURAL BRAIN RESEARCH

In search of evidence-based treatment for concussion: characteristics of current clinical trials

(2014) Matthew J. Burke et al.   BRAIN INJURY

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death

(2014) Hazel England et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

(2013) A. Denes et al.   Disease Models & Mechanisms

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

The Immune System in Stroke: Clinical Challenges and Their Translation to Experimental Research

(2013) Craig J. Smith et al.   Journal of Neuroimmune Pharmacology

A Concerted Appeal for International Cooperation in Preclinical Stroke Research

(2013) Ulrich Dirnagl et al.   STROKE

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

(2013) Busun Kim et al.   Frontiers in Immunology

Evolution of Inflammatory Diseases

(2012) Daniel Okin et al.   CURRENT BIOLOGY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Delayed Administration of Interleukin-1 Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Comorbid Rats

(2012) Jesus M Pradillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

International, Multicenter Randomized Preclinical Trials in Translational Stroke Research: It's Time to Act

(2012) Ulrich Dirnagl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome

(2012) Stephanie Adamczak et al.   JOURNAL OF NEUROSURGERY

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

(2011) Inna S. Afonina et al.   MOLECULAR CELL

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

(2010) AD Greenhalgh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Intravenous Anakinra can Achieve Experimentally Effective Concentrations in the Central Nervous System within a Therapeutic Time Window: Results of a Dose-Ranging Study

(2010) James Galea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Traumatic Brain Injury and Intestinal Dysfunction: Uncovering the Neuro-Enteric Axis

(2009) Vishal Bansal et al.   JOURNAL OF NEUROTRAUMA

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Systemic Inflammation Alters the Kinetics of Cerebrovascular Tight Junction Disruption after Experimental Stroke in Mice

(2008) B. W. McColl et al.   JOURNAL OF NEUROSCIENCE

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE