Review
Cell Biology
Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Singh
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor and non-motor dysfunctions. Platelets play an important role in Parkinson's disease and may be a target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Sangeun Han, Min Hyung Seo, Sabina Lim, Sujung Yeo
Summary: This study suggests a potential association between reduced ITGA7 expression and increased alpha-syn expression and apoptosis of dopaminergic cells in an MPTP-induced PD mouse model. This is the first study to show a link between ITGA7 and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Fares Bassil, Anna Delamarre, Marie-Helene Canron, Nathalie Dutheil, Anne Vital, Marie-Laure Negrier-Leibreich, Erwan Bezard, Pierre-Olivier Fernagut, Wassilios G. Meissner
Summary: The study found higher IRS-1pS312 expression in both PD patients and a preclinical rat model, indicating brain insulin resistance in PD and supporting the repurposing of anti-diabetic drugs for PD treatment.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jessica IChi Lai, Alessandra Porcu, Benedetto Romoli, Maria Keisler, Fredric P. P. Manfredsson, Susan B. B. Powell, Davide Dulcis
Summary: This study investigated the mechanism of how nicotine-induced dopamine (DA) plasticity protects substantia nigra (SN) neurons against nigrostriatal damage in Parkinson's disease (PD). The results showed that chronic nicotine treatment led to upregulation of transcription factor Nurr1 and DA-synthesizing enzyme tyrosine hydroxylase (TH) in GABAergic neurons in the SN. Nicotine also reduced the number of alpha-synuclein-expressing neurons and rescued motor deficits in PD mice. Importantly, the activation of GABA neurons and Nurr1 overexpression were sufficient to mimic nicotine-mediated dopamine plasticity. This study provides insights into developing new strategies for neurotransmitter replacement in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ezia Guatteo, Nicola Berretta, Vincenzo Monda, Ada Ledonne, Nicola Biagio Mercuri
Summary: This article focuses on the functional properties of nigral dopaminergic neurons and summarizes the shared or unique features of neuronal dysfunction in different stages of PD animal models, with the goal of illustrating the functional modifications occurring in these neurons during disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Vandana Zaman, Kelsey P. Drasites, Ali Myatich, Ramsha Shams, Donald C. Shields, Denise Matzelle, Azizul Haque, Narendra L. Banik
Summary: In this study, the researchers found that the activation of calpain-1 and calpain-2 in a nigrostriatal pathway has different effects on glial activation and neuronal survival in the Parkinson's disease (PD) model. They also found that attenuating calpain-2 may be important in reducing the loss of substantia nigra (SN) neurons in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Clare Tweedy, Nathan Kindred, Joshua Curry, Christopher Williams, John-Paul Taylor, Peter Atkinson, Fiona Randall, Daniel Erskine, Christopheer M. Morris, Amy K. Reeve, Gavin J. Clowry, Fiona E. N. LeBeau
Summary: In this study, network hyperexcitability was observed in early-stage DLB mice models, indicating that impairment of neuronal/synaptic function mediated by alpha-synuclein may lead to this phenomenon, even without the loss of PV interneurons. The therapeutic potential of targeting network excitability in the early stages of alpha-synucleinopathies like DLB should be further explored.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Cell Biology
Emilie Dinh, Thomas Rival, Alice Carrier, Noemi Asfogo, Olga Corti, Christophe Melon, Pascal Salin, Sylviane Lortet, Lydia Kerkerian-Le Goff
Summary: TP53INP1/dDOR plays a neuroprotective role in maintaining neuronal homeostasis, regulating autophagy and mitophagy in neurons. This has significant implications for neuroprotection and treatment of neurological disorders.
CELL DEATH & DISEASE
(2021)
Article
Clinical Neurology
Ada Ledonne, Mariangela Massaro Cenere, Emanuela Paldino, Vincenza D'Angelo, Sebastian Luca D'Addario, Nicolas Casadei, Annalisa Nobili, Nicola Berretta, Francesca R. Fusco, Rossella Ventura, Giuseppe Sancesario, Ezia Guatteo, Nicola Biagio Mercuri
Summary: Prolonged overexpression of alpha-synuclein has detrimental effects on the structural and functional properties of substantia nigra pars compacta dopamine neurons, including compromised soma and dendritic arborization, increased firing activity, and altered ion channel function.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Jayanth Anantha, Susan R. Goulding, Eszter Tuboly, Adam G. O'Mahony, Gerard M. Moloney, Gareth Lomansey, Cathal M. McCarthy, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: Parkinson's disease is a neurodegenerative disease characterized by the progressive degeneration of midbrain dopaminergic neurons and axonal degeneration. Research suggests that the neurotrophic factor NME1 may have potential as a therapeutic agent for axonal protection in PD, enhancing mitochondrial function and promoting neurite growth in cell models.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Srestha Mazumder, Anita Y. Bahar, Claire E. Shepherd, Asheeta A. Prasad
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra and aggregation of alpha-synuclein. Deep brain stimulation of the subthalamic nucleus is commonly used to treat motor symptoms in Parkinson's disease. However, the cellular changes in the subthalamic nucleus during Parkinson's disease and the impact of deep brain stimulation on the subthalamic nucleus and substantia nigra are not well understood.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jun Young Heo, Ah Hyung Park, Min Joung Lee, Min Jeong Ryu, Yong Kyung Kim, Yun Seon Jang, Soo Jeong Kim, So Yeon Shin, Hyo Jin Son, Thor D. Stein, Yang Hoon Huh, Sookja K. Chung, Song Yi Choi, Jin Man Kim, Onyou Hwang, Minho Shong, Seung Jae Hyeon, Junghee Lee, Hoon Ryu, Daesoo Kim, Gi Ryang Kweon
Summary: PD patients show reduced expression of CRIF1, a factor involved in the translation and membrane insertion of mitochondrial proteins. Mice lacking Crif1 gene in dopaminergic neurons exhibit PD-like symptoms, suggesting the importance of CRIF1 in mitochondrial function for dopaminergic neuron survival.
MOLECULAR PSYCHIATRY
(2023)
Article
Food Science & Technology
Lei Wang, Shengyu Li, Yu Jiang, Zijian Zhao, Yunjiao Shen, Junjie Zhang, Lei Zhao
Summary: Probiotic Lactobacillus plantarum DP189 has a significant protective effect on the dopaminergic neurons in the substantia nigra of Parkinson's disease mice, improving behavioral abilities and increasing neurotransmitter levels.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Neurosciences
Khadga Raj, Pawandeep Kaur, G. D. Gupta, Shamsher Singh
Summary: Parkinson's disease is a progressive neurological disorder caused by the degeneration of dopaminergic neurons, possibly influenced by exposure to heavy metals and trace elements. These metals can enter the brain and lead to dopaminergic neuronal damage, triggering oxidative stress and protein accumulation.
NEUROSCIENCE LETTERS
(2021)
Article
Cell Biology
Carmela Conte, Angela Ingrassia, John Breve, John J. J. Bol, Evelien Timmermans-Huisman, Anne-Marie van Dam, Tommaso Beccari, Wilma D. J. van de Berg
Summary: This study found an increased expression of Toll-like receptor 4 (TLR4) in the brains of Parkinson's disease (PD) patients, which colocalized with phosphorylated α-synuclein (pSer129-aSyn) at the site of damage, suggesting a potential role in mediating the neuroinflammatory response in PD.
Article
Biochemistry & Molecular Biology
Guillaume M. Fortin, Charles Ducrot, Nicolas Giguere, Willemieke M. Kouwenhoven, Marie-Josee Bourque, Consiglia Pacelli, Rafael Koerich Varaschin, Marion Brill, Sherdeep Singh, Paul W. Wiseman, Louis-Eric Trudeau
Article
Cell Biology
Ujval Anilkumar, Mireille Khacho, Alexanne Cuillerier, Richard Harris, David A. Patten, Maria Bilen, Mohamed Ariff Iqbal, Ding Yuan Guo, Louis-Eric Trudeau, David S. Park, Mary-Ellen Harper, Yan Burelle, Ruth S. Slack
CELL DEATH & DISEASE
(2020)
Article
Cell & Tissue Engineering
Jeremy F. Brooks, James E. M. Barber, Janet M. Davies, James W. Wells, Raymond J. Steptoe
Article
Immunology
Jeremy F. Brooks, Peter R. Murphy, James E. M. Barber, James W. Wells, Raymond J. Steptoe
JOURNAL OF IMMUNOLOGY
(2020)
Article
Neurosciences
Florence Allain, Benoit Delignat-Lavaud, Marie-Pierre Beaudoin, Vincent Jacquemet, Terry E. Robinson, Louis-Eric Trudeau, Anne-Noel Samaha
Summary: D-amphetamine maintenance therapy shows promise in reducing cocaine use by preventing sensitization-related changes in cocaine potency at the dopamine transporter (DAT).
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Physical
Gregory Q. Wallace, Benoit Delignat-Lavaud, Xingjuan Zhao, Louis-Eric Trudeau, Jean-Francois Masson
JOURNAL OF CHEMICAL PHYSICS
(2020)
Article
Gastroenterology & Hepatology
Tyler Cannon, Anshul Sinha, Louis-Eric Trudeau, Corinne F. Maurice, Samantha Gruenheid
Editorial Material
Neurosciences
Charles Ducrot, Louis-Eric Trudeau
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
William Tanguay, Charles Ducrot, Nicolas Giguere, Marie-Josee Bourque, Louis-Eric Trudeau
Summary: In Parkinson's disease, dopamine neurons in the substantia nigra pars compacta show unique vulnerability due to their large axonal arbors. By inducing partial SNc lesions in neonatal mice, researchers found that adult mice exhibited compensatory axonal sprouting in SNc DA neurons after neuronal loss.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Benoit Delignat-Lavaud, Charles Ducrot, Willemieke Kouwenhoven, Nina Feller, Louis-Eric Trudeau
Summary: This study uncovers clear differences in the mechanisms of somatodendritic (STD) and axonal dopamine release. STD dopamine release has low capacity and differs from axonal release in terms of molecular mechanisms.
Article
Neurosciences
Samuel Burke, Louis-Eric Trudeau
NPJ PARKINSONS DISEASE
(2022)
Article
Obstetrics & Gynecology
Sally Byford, Drishti Madhok, Paula Baldan, Guy Amey, James Barber, Rhys Harris, Graeme Walker
Summary: This study conducted a pilot implementation of a day case total laparoscopic hysterectomy (TLH) protocol in a tertiary hospital in Queensland. The feasibility, safety, and patient satisfaction of same-day discharge were assessed. The results showed that most patients were able to go home on the same day and reported high satisfaction. The implementation of this protocol can contribute to reduced hospital costs, improved theater efficiency, and patient flow while maintaining safety and satisfaction.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Clinical Neurology
Joseph Garcia Redmond, Liam R. Maclachlan, James Barber, Faruk Ayvaz, Damian Amato, Rumal Jayalath, Pattavilakom Ananthababu, Sarah Olson
Summary: We aimed to identify specific parameters, such as geometry, volume, and size of pituitary tumors, that could predict a higher risk of vision loss. Our methodology involved manual and video size measurements, as well as sub-voxel interpolation. The results showed a correlation between tumor volume and lateral chiasmal compression with pre-operative vision loss, and pre-operative visual impairment and suprasellar growth with post-operative vision loss.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
S. B. Nanni, M. -J. Bourque, L. -E. Trudeau
JOURNAL OF NEUROCHEMISTRY
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
B. Delignat-Lavaud, L. -E. Trudeau
JOURNAL OF NEUROCHEMISTRY
(2019)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)