SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-02-02
DOI
10.3389/fphar.2017.00956
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells
- (2017) DeJie Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma
- (2017) Changhwan Yoon et al. MOLECULAR CANCER RESEARCH
- Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling
- (2017) Wei-xiang Peng et al. Frontiers in Immunology
- Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
- (2016) Ann Hanna et al. Molecular Cancer
- The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
- (2016) C Battistelli et al. ONCOGENE
- Control of inflammation by stromal Hedgehog pathway activation restrains colitis
- (2016) John J. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
- (2016) Marco Gerling et al. Nature Communications
- In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors
- (2016) Monica Benvenuto et al. Oncotarget
- Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer
- (2016) Rong Wang et al. Oncotarget
- Increased chemoresistance via Snail–Raf kinase inhibitor protein signaling in colorectal cancer in response to a nicotine derivative
- (2016) Tsai-Yu Lee et al. Oncotarget
- Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
- (2016) Tadas Rimkus et al. Cancers
- Hedgehog Pathway Inhibitors Promote Adaptive Immune Responses in Basal Cell Carcinoma
- (2015) A. Otsuka et al. CLINICAL CANCER RESEARCH
- Rho GTPase signalling in cell migration
- (2015) Anne J Ridley CURRENT OPINION IN CELL BIOLOGY
- Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update
- (2015) Naoko Takebe et al. Nature Reviews Clinical Oncology
- Acquisition of 5-fluorouracil resistance induces epithelial-mesenchymal transitions through the Hedgehog signaling pathway in HCT-8 colon cancer cells
- (2015) YANJUN LIU et al. Oncology Letters
- Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition
- (2015) Napapan Kangwan et al. Oncotarget
- A loss-of-function mutation in PTCH1 suggests a role for autocrine hedgehog signaling in colorectal tumorigenesis
- (2015) Jon H. Chung et al. Oncotarget
- Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer
- (2014) Jillian Brechbiel et al. CANCER TREATMENT REVIEWS
- Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients
- (2014) T. Z. Tan et al. EMBO Molecular Medicine
- Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis
- (2014) R. Strippoli et al. EMBO Molecular Medicine
- EMT is the dominant program in human colon cancer
- (2013) Andre Loboda et al. BMC Medical Genomics
- The glypican 3 hepatocellular carcinoma marker regulates human hepatic stellate cells via Hedgehog signaling
- (2013) Paolo Magistri et al. JOURNAL OF SURGICAL RESEARCH
- Unraveling the therapeutic potential of the Hedgehog pathway in cancer
- (2013) Dereck Amakye et al. NATURE MEDICINE
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened
- (2013) Kai Sun WORLD JOURNAL OF GASTROENTEROLOGY
- Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway
- (2012) Tz-Ping Wang et al. CARCINOGENESIS
- Developmental pathways in colon cancer
- (2012) Fred E. Bertrand et al. CELL CYCLE
- A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer
- (2012) J. Berlin et al. CLINICAL CANCER RESEARCH
- Molecular pathways in colorectal cancer
- (2012) Sam Al-Sohaily et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Overlapping activities of TGF-β and Hedgehog signaling in cancer: Therapeutic targets for cancer treatment
- (2012) Carole Y. Perrot et al. PHARMACOLOGY & THERAPEUTICS
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- Prognostic value of hedgehog signaling pathway in patients with colon cancer
- (2011) Meihua Xu et al. MEDICAL ONCOLOGY
- Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
- (2010) Gerrit J. P. Dijkgraaf et al. CANCER RESEARCH
- Review: Targeting the Hedgehog pathway in cancer
- (2010) Sachin Gupta et al. Therapeutic Advances in Medical Oncology
- Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
- (2009) Frédéric Varnat et al. EMBO Molecular Medicine
- GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
- (2009) O. Nolan-Stevaux et al. GENES & DEVELOPMENT
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation
- (2009) Beate Alinger et al. VIRCHOWS ARCHIV
- Regulation of In Situ to Invasive Breast Carcinoma Transition
- (2008) Min Hu et al. CANCER CELL
- Hedgehog Signaling in Development and Cancer
- (2008) Jin Jiang et al. DEVELOPMENTAL CELL
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started