Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs

HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats

(2012) Tatsuya Usui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Selective Histone Deacetylase Inhibitors

(2012) Huili Pan et al.   Anti-Cancer Agents in Medicinal Chemistry

Development and therapeutic impact of HDAC6-selective inhibitors

(2012) Sabrina Dallavalle et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of Histone Deacetylase 3 Protects Beta Cells from Cytokine-Induced Apoptosis

(2012) Danny Hung-Chieh Chou et al.   CHEMISTRY & BIOLOGY

Synthesis and Biological Evaluation ofortho-ArylN-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

(2012) Wei-Jan Huang et al.   ChemMedChem

Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells

(2012) Carrie S. Soltanoff et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed

(2012) Berkley E Gryder et al.   Future Medicinal Chemistry

Histone Deacetylase 3 Mediates Allergic Skin Inflammation by Regulating Expression of MCP1 Protein

(2012) Youngmi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoke exposure of human macrophages reduces HDAC3 activity, resulting in enhanced inflammatory cytokine production

(2012) Aaron R. Winkler et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

A Novel Class of Small Molecule Inhibitors of HDAC6

(2011) Elizabeth S. Inks et al.   ACS Chemical Biology

Trichostatin A Abrogates Airway Constriction, but Not Inflammation, in Murine and Human Asthma Models

(2011) Audreesh Banerjee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

(2011) Aleksander M Grabiec et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis

(2011) Jelena Vojinovic et al.   ARTHRITIS AND RHEUMATISM

Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients

(2011) Justin Gillespie et al.   ARTHRITIS AND RHEUMATISM

RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation

(2011) Jung Ha Kim et al.   BIOCHEMICAL JOURNAL

Discovery of histone deacetylase 8 selective inhibitors

(2011) Weiping Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

HDAC3 and HDAC7 Have Opposite Effects on Osteoclast Differentiation

(2011) Lan Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase 9 Deficiency Protects against Effector T Cell-mediated Systemic Autoimmunity

(2011) Kailin Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro

(2011) M.D. Cantley et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in CD4/CD8 Double-Positive Thymocytes

(2011) H. G. Kasler et al.   JOURNAL OF IMMUNOLOGY

Histone deacetylase inhibitors and periodontal bone loss

(2011) M. D. Cantley et al.   JOURNAL OF PERIODONTAL RESEARCH

Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells

(2011) E. F. de Zoeten et al.   MOLECULAR AND CELLULAR BIOLOGY

HDAC6 Regulates LPS-Tolerance in Astrocytes

(2011) Eléonore Beurel   PLoS One

HDAC inhibitor MS-275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis

(2011) Zhi-Yuan Zhang et al.   PROSTATE

Inhibitors selective for HDAC6 in enzymes and cells

(2010) Praveer K. Gupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Histone Deacetylase Inhibitors Suppress Inflammatory Activation of Rheumatoid Arthritis Patient Synovial Macrophages and Tissue

(2010) Aleksander M. Grabiec et al.   JOURNAL OF IMMUNOLOGY

Conditional Deletion of Histone Deacetylase 1 in T Cells Leads to Enhanced Airway Inflammation and Increased Th2 Cytokine Production

(2010) R. Grausenburger et al.   JOURNAL OF IMMUNOLOGY

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

(2010) Maria A. Halili et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritis

(2010) Z.Y. Zhang et al.   NEUROSCIENCE

Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages

(2009) Sang-Bae Han et al.   ARCHIVES OF PHARMACAL RESEARCH

Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS

(2009) W. Wang et al.   BLOOD

Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells

(2009) Young-Sook Baek et al.   BMC IMMUNOLOGY

Isoform-specific histone deacetylase inhibitors: The next step?

(2009) Sriram Balasubramanian et al.   CANCER LETTERS

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

(2009) Fernando Rivadeneira et al.   NATURE GENETICS

Role of HDAC2 in the Pathophysiology of COPD

(2008) Peter J. Barnes   Annual Review of Physiology

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

(2008) David V. Smil et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quantitative Analysis of Histone Deacetylase-1 Selective Histone Modifications by Differential Mass Spectrometry

(2008) Anita Y. H. Lee et al.   JOURNAL OF PROTEOME RESEARCH

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model

(2008) Y. Nasu et al.   OSTEOARTHRITIS AND CARTILAGE