Journal
ATHEROSCLEROSIS
Volume 240, Issue 2, Pages 355-366Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2014.12.048
Keywords
HDACs; Endothelial cells; Macrophage cells; Vascular smooth muscle cells; Plaque; Thrombosis
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Atherosclerosis is the most common pathological process that leads to cardiovascular diseases, a disease of large- and medium-sized arteries that is characterized by a formation of atherosclerotic plaques consisting of necrotic cores, calcified regions, accumulated modified lipids, smooth muscle cells (SMCs), endothelial cells, leukocytes, and foam cells. Recently, the question about how to suppress the occurrence of atherosclerosis and alleviate the progress of cardiovascular disease becomes the hot topic. Accumulating evidence suggests that histone deacetylases(HDACs) play crucial roles in arteriosclerosis. This review summarizes the effect of HDACs and HDAC inhibitors(HDACi) on the progress of atherosclerosis. (C) 2015 Published by Elsevier Ireland Ltd.
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